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Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study

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Abstract

Advanced glycation end products (AGEs) are bioactive molecules found in foods and generated endogenously in the body. AGEs induce cross-linking of collagen and increase the stiffness of skeletal muscle and cartilage. We characterized the relationship between a plasma AGE, carboxymethyl-lysine (CML), and slow walking speed (lowest quintile of walking speed) in older adults. Walking speed over a 4 m course was assessed in 944 adults, aged ≥65 years, in the InCHIANTI study, a population-based study of aging and mobility disability conducted in two towns in Tuscany, Italy. Participants in the highest quartile of plasma CML were at higher risk of slow walking speed (Odds Ratio [O.R.] 1.56, 95% Confidence Interval [C.I.] 1.02–2.38, P = 0.04) compared to those in the lower three quartiles of plasma CML in a logistic regression models adjusting for age, education, cognitive function, smoking, and chronic diseases. After exclusion of participants with diabetes, participants in the highest quartile of plasma CML were at higher risk of slow walking speed (O.R. 1.87, 95% C.I. 1.15–3.04, P = 0.01) adjusting for the same covariates. In older community-dwelling adults, elevated plasma CML is independently associated with slow walking speed.

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Acknowledgments

This work was supported by National Institute on Aging Grant R01 AG027012, R56 AG027012, R01 AG029148 and the Intramural Research Program, National Institute on Aging, NIH.

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Authors and Affiliations

  1. Department of Ophthalmology, Johns Hopkins University School of Medicine, 550 N. Broadway, Suite 700, Baltimore, MD, 21205, USA

    Richard D. Semba & Kai Sun

  2. Azienda Sanitaria Firenze, Florence, Italy

    Stefania Bandinelli

  3. Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA

    Jack M. Guralnik

  4. Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, Baltimore, MD, USA

    Luigi Ferrucci

Authors
  1. Richard D. Semba
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  2. Stefania Bandinelli
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  3. Kai Sun
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  4. Jack M. Guralnik
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  5. Luigi Ferrucci
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Correspondence to Richard D. Semba.

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Semba, R.D., Bandinelli, S., Sun, K. et al. Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study. Eur J Appl Physiol 108, 191–195 (2010). https://doi.org/10.1007/s00421-009-1192-5

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