Skip to main content
SpringerLink
Log in

Home-based resistance training improves arterial stiffness in healthy premenopausal women

  • Original Article
  • Published:
European Journal of Applied Physiology Aims and scope Submit manuscript

Abstract

The present study investigates the effect of home-based resistance training on arterial stiffness in healthy premenopausal women. Twelve healthy non-smoking and normotensive women who were not actively involved in regular physical exercise (aged 42–55 years) performed home-based resistance training twice weekly for 10 weeks using body weight and light dumbbells. Each training session required approximately 40 min to complete. Arterial stiffness was measured using brachial-ankle pulse wave velocity (baPWV). We also determined serum total cholesterol, HDL cholesterol, glucose, triglyceride, insulin, and adiponectin and calculated the homeostasis model assessment of insulin resistance (HOMA-IR), an index of insulin resistance. After home-based resistance training, baPWV, total cholesterol, LDL cholesterol, insulin, and the HOMA-IR decreased, whereas adiponectin increased (P < 0.05) and levels of HDL cholesterol, glucose, triglyceride, blood pressure, and heart rate remained unaffected. These results suggest that home-based resistance training benefits vascular function in healthy premenopausal women.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Begum N, Song Y, Rienzie J, Ragolia L (1988) Vascular smooth muscle cell growth and insulin regulation of mitogen-activated protein kinase in hypertension. Am J Physiol 275:C42–C49

    Google Scholar 

  • Blair SN, Kohl HW, Barlow CE, Paffenbarger RS, Gibbons LW, Macera CA (1995) Changes in physical fitness and all-cause mortality. A prospective study of healthy and unhealthy men. JAMA 273:1093–1098. doi:10.1001/jama.273.14.1093

    Article  PubMed  CAS  Google Scholar 

  • Casey DP, Pierce GL, Howe KS, Mering MC, Braith RW (2007) Effect of resistance training on arterial wave reflection and brachial artery reactivity in normotensive postmenopausal women. Eur J Appl Physiol 100:403–408. doi:10.1007/s00421-007-0447-2

    Article  PubMed  Google Scholar 

  • Fatouros IG, Tournis S, Leontsini D, Jamurtas AZ, Sxina M, Thomakos P, Manousaki M, Douroudos I, Taxildaris K, Mitrakou A (2005) Leptin and adiponectin responses in overweight inactive elderly following resistance training and detraining are intensity related. J Clin Endocrinol Metab 90:5970–5977. doi:10.1210/jc.2005-0261

    Article  PubMed  CAS  Google Scholar 

  • Guyton JR, Lindsay KL, Dao DT (1983) Comparisons of aortic intima and inner media in young versus aging rats: stereology in a polarized system. Am J Pathol 111:234–246

    PubMed  CAS  Google Scholar 

  • Kasayama S, Saito H, Mukai M, Koga M (2005) Insulin sensitivity independently influences brachial-ankle pulse-wave velocity in non-diabetic subjects. Diabet Med 22:1701–1706. doi:10.1111/j.1464-5491.2005.01718.x

    Article  PubMed  CAS  Google Scholar 

  • Klimcakova E, Polak J, Moro C, Hejnova J, Majercik M, Viguerie N, Berlan M, Langin D, Stich V (2006) Dynamic strength training improves insulin sensitivity without altering plasma levels and gene expression of adipokines in subcutaneous adipose tissue in obese men. J Clin Endocrinol Metab 91:5107–5112

    Article  CAS  Google Scholar 

  • Kozakova M, Palombo C, Mhamdi L, Konrad T, Nilsson P, Staehr PB, Paterni M, Balkau B, Investigators RISC (2007) Habitual physical activity and vascular aging in a young to middle-age population at low cardiovascular risk. Stroke 38:2549–2555. doi:10.1161/STROKEAHA.107.484949

    Article  PubMed  Google Scholar 

  • Lazarevic G, Antic S, Cvetkovic T, Vlahovic P, Tasic I, Stefanovic V (2006) A physical activity programme and its effects on insulin resistance and oxidative defense in obese male patients with type 2 diabetes mellitus. Diabetes Metab 32:583–590. doi:10.1016/S1262-3636(07)70312-9

    Article  PubMed  CAS  Google Scholar 

  • Mahmud A, Feely J (2005) Adiponectin and arterial stiffness. Am J Hypertens 18:1543–1548. doi:10.1016/j.amjhyper.2005.06.014

    Article  PubMed  CAS  Google Scholar 

  • Matsuda M, Shimomura I, Sata M, Arita Y, Nishida M, Maeda N, Kumada M, Okamoto Y, Nagaretani H, Nishizawa H, Kishida K, Komuro R, Ouchi N, Kihara S, Nagai R, Funahashi T, Matsuzawa Y (2002) Role of adiponectin in preventing vascular stenosis. The missing link of adipo-vascular axis. J Biol Chem 277:37487–37491. doi:10.1074/jbc.M206083200

    Article  PubMed  CAS  Google Scholar 

  • Miura H, Aoki S (2005) Influence of low-intensity circuit training on artery stiffness in female. Jpn J Phys Fit Sports Med 54:205–210 in Japanese, English abstract

    Google Scholar 

  • Miura S, Tanaka E, Mori A, Toya M, Takahashi K, Nakahara K, Ohmichi M, Kurachi H (2003) Hormone replacement therapy improves arterial stiffness in normotensive postmenopausal women. Maturitas 45:293–298. doi:10.1016/S0378-5122(03)00158-0

    Article  PubMed  CAS  Google Scholar 

  • Miura H, Nakagawa E, Takahashi Y (2008) Influence of group training frequency on arterial stiffness in elderly women. Eur J Appl Physiol 104:1039–1044. doi:10.1007/s00421-008-0860-1

    Article  PubMed  Google Scholar 

  • Nakamura Y, Tanaka K, Yabushita N, Sakai T, Shigematsu R (2007) Effects of exercise frequency on functional fitness in older adult women. Arch Gerontol Geriatr 44:163–173. doi:10.1016/j.archger.2006.04.007

    Article  PubMed  Google Scholar 

  • Ouchi N, Kihara S, Arita Y, Okamoto Y, Maeda K, Kuriyama H, Hotta K, Nishida M, Takahashi M, Muraguchi M, Ohmoto Y, Nakamura T, Yamashita S, Funahashi T, Matsuzawa Y (2000) Adiponectin, an adipocyte-derived plasma protein, inhibits endothelial NF-kappaB signaling through a cAMP-dependent pathway. Circulation 102:1296–1301

    PubMed  CAS  Google Scholar 

  • Ouchi N, Kihara S, Arita Y, Nishida M, Matsuyama A, Okamoto Y, Ishigami M, Kuriyama H, Kishida K, Nishizawa H, Hotta K, Muraguchi M, Ohmoto Y, Yamashita S, Funahashi T, Matsuzawa Y (2001) Adipocyte-derived plasma protein, adiponectin, suppresses lipid accumulation and class A scavenger receptor expression in human monocyte-derived macrophages. Circulation 103:1057–1063

    PubMed  CAS  Google Scholar 

  • Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR (2000) Aging, habitual exercise, and dynamic arterial compliance. Circulation 102:1270–1275

    PubMed  CAS  Google Scholar 

  • ter Maaten JC, Bakker SJ, Serné EH, ter Wee PM, Donker AJ, Gans RO (1999) Insulin’s acute effects on glomerular filtration rate correlate with insulin sensitivity whereas insulin’s acute effects on proximal tubular sodium reabsorption correlate with salt sensitivity in normal subjects. Nephrol Dial Transplant 14:2357–2363. doi:10.1093/ndt/14.10.2357

    Article  PubMed  Google Scholar 

  • Thuillez C, Richard V (2005) Targeting endothelial dysfunction in hypertensive subjects. J Hum Hypertens 19:S21–S25. doi:10.1038/sj.jhh.1001889

    Article  PubMed  CAS  Google Scholar 

  • Tomiyama H, Yamashina A, Arai T, Hirose K, Koji Y, Chikamori T, Hori S, Yamamoto Y, Doba N, Hinohara S (2003) Influences of age and gender on results of noninvasive brachial-ankle pulse wave velocity measurement—a survey of 12517 subjects. Atherosclerosis 166:303–309. doi:10.1016/S0021-9150(02)00332-5

    Article  PubMed  CAS  Google Scholar 

  • Weinberger MH, Fineberg NS, Fineberg SE (2002) Effects of age, race, gender, blood pressure, and estrogen on arterial compliance. Am J Hypertens 15:358–363. doi:10.1016/S0895-7061(02)02261-6

    Article  PubMed  Google Scholar 

  • Williams MR, Westerman RA, Kingwell BA, Paige J, Blombery PA, Sudhir K, Komesaroff PA (2001) Variations in endothelial function and arterial compliance during the menstrual cycle. J Clin Endocrinol Metab 86:5389–5395. doi:10.1210/jc.86.11.5389

    Article  PubMed  CAS  Google Scholar 

  • Yamasaki F, Furuno T, Sato K, Zhang D, Nishinaga M, Sato T, Doi Y, Sugiura T (2005) Association between arterial stiffness and platelet activation. J Hum Hypertens 19:527–533. doi:10.1038/sj.jhh.1001861

    Article  PubMed  CAS  Google Scholar 

  • Yoshizawa M, Maeda S, Miyaki A, Misono M, Saito Y, Tanabe K, Kuno S, Ajisaka R (2009) Effect of 12 weeks of moderate-intensity resistance training on arterial stiffness: a randomized controlled trial in women aged 32–59. Br J Sports Med (in press)

  • Young JB (1988) Effect of experimental hyperinsulinemia on sympathetic nervous system activity in the rat. Life Sci 43:193–200. doi:10.1016/0024-3205(88)90297-4

    Article  PubMed  CAS  Google Scholar 

  • Zureik M, Bureau JM, Temmar M, Adamopoulos C, Courbon D, Bean K, Touboul PJ, Benetos A, Ducimetière P (2003) Echogenic carotid plaques are associated with aortic arterial stiffness in subjects with subclinical carotid atherosclerosis. Hypertension 41:519–527. doi:10.1161/01.HYP.0000054978.86286.92

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Health Science and Applied Physiology, Kinki Welfare University, 1966-5, Takaoka, Fukusaki-cho, Kanzaki-gun, Hyogo, 679-2217, Japan

    Takanobu Okamoto

  2. Institute of Exercise Physiology and Biochemistry, Osaka University of Health and Sport Sciences, 1-1 Asashirodai, Kumatori-cho, Sennan-gun, Osaka, 590-0496, Japan

    Mitsuhiko Masuhara

  3. Institute of Health and Child Sciences, Osaka Aoyama University, 2-11-1 Niina, Minoh, Osaka, 562-8580, Japan

    Komei Ikuta

Authors
  1. Takanobu Okamoto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mitsuhiko Masuhara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Komei Ikuta
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Takanobu Okamoto.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Okamoto, T., Masuhara, M. & Ikuta, K. Home-based resistance training improves arterial stiffness in healthy premenopausal women. Eur J Appl Physiol 107, 113–117 (2009). https://doi.org/10.1007/s00421-009-1102-x

Download citation

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00421-009-1102-x

Keywords

Search

Navigation