Abstract
The aims of this study were to (1) quantify any central fatigue that occurs following prolonged dynamic exercise, i.e. reduced muscle force caused by impaired motor drive from the central nervous system and (2) determine whether decreased cortical arousal, assessed using critical flicker fusion threshold (CFF), occurs and is related to impaired exercise performance. Fifteen healthy men cycled at 70% VO2peak until exhaustion. The peak force of maximum voluntary isometric contractions (MVC) of the quadriceps muscle group was reduced by 30% at exhaustion. The voluntary activation ratio determined using superimposed tetanic stimulation fell from 0.99 to 0.86 at exhaustion. The central fatigue (%) at exhaustion was 33±12% (± SD) (assessed via the tetanus interpolation technique) and 54±32% (assessed via the relative decline of MVC and peak tetanic force) of the total fatigue. The MVC only partially recovered and central fatigue persisted at 30 min post-exercise. CFF increased from 39.2±2.3 to 41.8±3.5 Hz at exhaustion, but did not correlate with central fatigue. Every subject reached the highest rating of perceived exertion (RPE) at exhaustion of 20 on the Borg scale. The time to exhaustion was related to how quickly the RPE increased and to the ability to sustain exercise at very high RPE. These data suggest that with prolonged cycling: (1) there is considerable and a persistent form of central fatigue, (2) there is an increased level of cortical arousal, and (3) exhaustion is linked to very high subjective RPE.
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Adams GR, Harris RT, Woodard D, Dudley GA (1993) Mapping of electrical muscle stimulation using MRI. J Appl Physiol 74:532–537
Béquet F, Gomez-Merino D, Berthelot M, Guezennec CY (2002) Evidence that brain glucose availability influences exercise-enhanced extracellular 5-HT level in hippocampus: a microdialysis study in exercising rats. Acta Physiol Scand 176:65–69
Bergström J, Hermansen L, Hultman E, Saltin B (1967) Diet, muscle glycogen and physical performance. Acta Physiol Scand 71:140–150
Bigland-Ritchie B, Jones DA, Hosking GP, Edwards RHT (1978) Central and peripheral fatigue in sustained maximum voluntary contractions of human quadriceps muscle. Clin Sci Mol Med 54:609–614
Booth J, McKenna MJ, Ruell PA, Gwinn TH, Davis GM, Thompson MW, Harmer AR, Hunter SK, Sutton JR (1997) Impaired calcium pump function does not slow relaxation in human skeletal muscle after prolonged exercise. J Appl Physiol 83:511–521
Borg G (1970) Perceived exertion as an indicator of somatic stress. Scand J Rehab Med 2:92–98
Burgess ML, Robertson RJ, Davis JM, Norris JM (1991) RPE, blood glucose, and carbohydrate oxidation during prolonged exercise: effects of glucose feedings. Med Sci Sports Exerc 23:353–359
Cairns SP, Hing WA, Slack JR, Mills RG, Loiselle DS (1997) Different effects of raised [K+]o on membrane potential and contraction in mouse fast- and slow-twitch muscle. Am J Physiol 273:C598–C611
Chin ER, Allen DG (1997) Effects of reduced muscle glycogen concentration on force, Ca2+ release and contractile protein function in intact mouse skeletal muscle. J Physiol 498(1):17–29
Coyle EF, Coggan AR, Hemmert MK, Ivy JL (1986) Muscle glycogen utilization during prolonged strenuous exercise when fed carbohydrate. J Appl Physiol 61:165–172
Davies CTM, Thompson MW (1986) Physiological responses to prolonged exercise in ultramarathon athletes. J Appl Physiol 61:611–617
Davis JM, Bailey SP (1997) Possible mechanisms of central nervous system fatigue during exercise. Med Sci Sports Exerc 29:45–57
Davranche K, Audiffren M (2004) Facilitating effects of exercise on information processing. J Sports Sci 22:419–428
Douchamps-Riboux F, Heinz JK, Douchamps J (1989) Arousal as a tridimensional variable: an exploratory study of behavioural changes in rowers following a marathon race. Int J Sport Psychol 20:31–41
Enoka RM (2002) Activation order of motor axons in electrically evoked contractions. Muscle Nerve 25:763–764
Gandevia SC (2001) Spinal and supraspinal factors in human muscle fatigue. Physiol Rev 81:1725–1789
Gollnick PD, Armstrong RB, Saubert IV CW, Sembrowich WL, Shepherd RE, Saltin B (1973) Glycogen depletion patterns in human skeletal muscle fibers during prolonged work. Pflügers Arch 344:1–12
Green HJ (1991) How important is endogenous muscle glycogen to fatigue in prolonged exercise? Can J Physiol Pharmacol 69:290–297
Hill CA, Thompson MW, Ruell PA, Thom JM, White MJ (2001) Sarcoplasmic reticulum function and muscle contractile character following fatiguing exercise in humans. J Physiol 531(3):871–878
Hosokawa T, Mikami K, Saito K (1997) Basic study of the portable fatigue meter: effects of illumination, distance from eyes and age. Ergonomics 40:887–894
Hultman E, Sjöholm H, Jäderholm-Ek I, Krynicki J (1983) Evaluation of methods for electrical stimulation of human skeletal muscle in situ. Pflügers Arch 398:139–141
Kang J, Robertson RJ, Goss FL, DaSilva SG, Visich P, Suminski RR, Utter AC, Denys BG (1996) Effect of carbohydrate substrate availability on ratings of perceived exertion during prolonged exercise of moderate intensity. Percept Motor Skills 82:495–506
Kent-Braun J, Le Blanc R (1996) Quantification of central activation failure during maximal voluntary contractions in humans. Muscle Nerve 19:861–869
Landis C (1954) Determinants of the critical flicker-fusion threshold. Physiol Rev 34:259–286
Lepers R, Maffiuletti NA, Rochette L, Brugniaux J, Millet GY (2002) Neuromuscular fatigue during a long-duration cycling exercise. J Appl Physiol 92:1487–1493
Leppik JA, Aughey RJ, Medved I, Fairweather I, Carey MF, McKenna MJ (2004) Prolonged exercise to fatigue in humans impairs skeletal muscle Na+–K+-ATPase activity, sarcoplasmic reticulum Ca2+ release, and Ca2+ uptake. J Appl Physiol 97:1414–1423
Marvin G, Sharma A, Aston W, Field C, Kendall MJ, Jones DA (1997) The effects of buspirone on perceived exertion and time to fatigue in man. Exp Physiol 82:1057–1060
Miller M, Downham D, Lexell J (1999) Superimposed single impulse and pulse train electrical stimulation: a quantitative assessment during submaximal isometric knee extension in young, healthy men. Muscle Nerve 22:1038–1046
Millet GY, Martin V, Lattier G, Ballay Y (2003) Mechanisms contributing to knee extensor strength loss after prolonged running exercise. J Appl Physiol 94:193–198
Nathan PJ, Sitaram G, Stough C, Silberstein RB, Sali A (2000) Serotonin, noradrenaline and cognitive function: a preliminary investigation of the acute pharamacodynamic effects of a serotonin versus a serotonin and noradrenaline reuptake inhibitor. Behav Pharmacol 11:639–642
Newman SA, Jones G, Newham DJ (2003) Quadriceps voluntary activation at different joint angles measured by two stimulation techniques. Eur J Appl Physiol 89:496–499
Nybo L, Nielsen B (2001) Perceived exertion is associated with an altered brain activity during exercise with progressive hyperthermia. J Appl Physiol 91:2017–2023
Nybo L, Secher NH (2004) Cerebral perturbations provoked by prolonged exercise. Prog Neurobiol 72:223–261
Rammsayer T, Netter P (1988) Effects of changes in brain 5-HT activity on indicators of cortical arousal. Int Clin Psychopharmacol 3:231–237
Sahlin K, Seger JY (1995) Effects of prolonged exercise on the contractile properties of human quadriceps muscle. Eur J Appl Physiol 71:180–186
Simonson E, Brožek J (1952) Flicker fusion frequency: background and applications. Physiol Rev 32:349–378
St Clair Gibson A, Noakes TD (2004) Evidence for complex system integration and dynamic neural regulation of skeletal muscle recruitment during exercise in humans. Br J Sports Med 38:797–806
Steensberg A, Febbraio MA, Osada T, Schjerling P, van Hall G, Saltin B, Pedersen BK (2001) Interleukin-6 production in contracting human skeletal muscle is influenced by pre-exercise muscle glycogen content. J Physiol 537(2):633–639
Vøllestad NK (1987) Motor unit recruitment: a histochemical approach. Med Sport Sci 26:128–141
Acknowledgements
We gratefully thank Drs. Andrew Kilding, Denis Loiselle, Will Hopkins and Martin Thompson for helpful discussions, and our subjects for volunteering to participate in this study.
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Presland, J.D., Dowson, M.N. & Cairns, S.P. Changes of motor drive, cortical arousal and perceived exertion following prolonged cycling to exhaustion. Eur J Appl Physiol 95, 42–51 (2005). https://doi.org/10.1007/s00421-005-1395-3
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DOI: https://doi.org/10.1007/s00421-005-1395-3