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Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states

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An Erratum to this article was published on 01 April 2003

Abstract

This study aimed to determine whether changes in plasma heparin-releasable lipoprotein lipase (LPL) activity following a brisk walk were associated with decreases in fasting and/or postprandial triglyceride (TG) concentrations. Two groups of pre-menopausal women participated. In one group (fasting study group, n=10), TG concentrations and post-heparin plasma LPL activity were measured in the fasted state on two occasions: ~18 h after a 2-h treadmill walk at 50% maximal oxygen uptake (exercise trial); and after a day of no exercise (control trial). The other group (postprandial study group, n=9) undertook two oral fat tolerance tests (blood samples taken fasting and for 6 h after a high-fat meal), with plasma LPL activity measured 6 h after meal ingestion. Pre-conditions were the same as for the fasting study group (i.e. control and prior exercise). Prior exercise reduced fasting TG concentrations by 23 (7)% (fasting study group) [mean (SEM)] and by 18 (9)% (postprandial study group) (both P<0.05), and the postprandial TG response by 23 (6)% (postprandial study group) (P<0.01). Plasma LPL activity was not significantly increased by exercise in either the fasting or postprandial study groups. However, exercise-induced changes in both fasting and postprandial LPL activity were significantly correlated with the respective exercise-induced changes in fasting TG concentration and the postprandial TG response (r=−0.70 and −0.77 respectively, P<0.05 for both). These data suggest that increased LPL activity may contribute to the hypotriglyceridaemic effect of moderate exercise, although other mechanisms are also likely to be involved.

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Acknowledgements

This work was supported by the British Heart Foundation. The authors are grateful to Dr. Jacky Knapper and Dr. Catriona Brooks of the School of Biological Sciences, University of Surrey for advice with the assay for determining LPL activity. We also thank Dr. Mike Morgan of Glenfield Hospital, Leicester for help with data collection. The experiments undertaken in this study comply with current UK laws.

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Authors and Affiliations

  1. Department of Pathological Biochemistry, Glasgow Royal Infirmary, 4th Floor, Queen Elizabeth Building, Glasgow, UK

    Jason M. R. Gill

  2. School of Sport and Exercise Sciences, Loughborough University, Loughborough, UK

    Sara L. Herd & Adrianne E. Hardman

  3. Sheffield Teaching Hospitals Trust, Sheffield, UK

    Vandana Vora

Authors
  1. Jason M. R. Gill
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  2. Sara L. Herd
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  3. Vandana Vora
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  4. Adrianne E. Hardman
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Correspondence to Jason M. R. Gill.

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An erratum to this article is available at http://dx.doi.org/10.1007/s00421-003-0827-1.

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Gill, J.M.R., Herd, S.L., Vora, V. et al. Effects of a brisk walk on lipoprotein lipase activity and plasma triglyceride concentrations in the fasted and postprandial states. Eur J Appl Physiol 89, 184–190 (2003). https://doi.org/10.1007/s00421-002-0788-9

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