Abstract
Reductions in tonic vagal controls of the heart and depressed baroreflex sensitivity (BRS) have been associated with a postural fall in blood pressure (BP) and the incidence of cardiac events among older people. We examined the hypothesis that BP regulation during orthostatic challenge as well as heart rate variability (HRV) at rest can be better maintained in long-term exercise-trained, healthy, older men (aged 60–70 years). Subjects were classified into two groups; long-term exercise-trained (LTET, n=14) and sedentary (SED, n=10) according to their history of physical activity. Prior to the dynamic BRS assessment, supine resting autonomic cardiac modulation was assessed by means of time domain HRV [standard deviation of ECG R–R interval (RRISD) and the coefficient of variation (CV)]. The BRS was assessed during 60° head-up tilting by simultaneously measuring beat-by-beat systolic blood pressure (SBP) and ECG R–R interval changes. The BRS gain was determined by the regression slope coefficient based on the extent of the SBP fall and the corresponding ECG R–R shortening during the orthostatic challenge. The results indicated that the LTET group manifested greater ECG R–R interval fluctuations with significantly higher resting RRISD and CV, compared with the SED group [59.5 (10.4) versus 27.7 (7.8) ms, p<0.05; 5.5 (0.8) versus 2.8 (0.7)%, p<0.05], respectively. Using dynamic BRS testing during the acute orthostatic challenge, the LTET group showed a significantly higher BRS gain than the SED [6.4 (0.8) versus 3.8 (0.6) ms·mmHg−1, p<0.017] group. These results indicate that CV and BRS are well maintained in healthy, LTET older individuals when compared with their sedentary peers. Our data suggest that this augmented autonomic cardiac modulation reflects better parasympathetic responsiveness in LTET individuals. Data provide further support for long-term exercise training as another possible cardioprotective factor that might decrease susceptibility to ventricular fibrillation as well as assist arterial BP at the onset of an orthostatic challenge in older men.
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References
Billman GE, Schwartz PJ, Stone HL (1984) The effects of daily exercise on susceptibility to sudden cardiac death. Circulation 69:1182–1189
Blomqvist VG, Stone HL (1983) Cardiovascular adjustment to gravitational stress. In: Shephard JT, Abboud FM (eds) Handbook of physiology. The cardiovascular system. Peripheral circulation and organ blood flow. American Physiological Society, Bethesda, Md., pp 1025–1063
Bowman AJ, Clayton RH, Murray A, Reed JW, Subhan MM, Ford GA (1997) Effects of aerobic exercise training and yoga on the baroreflex in health elderly persons. Eur J Clin Invest 27:443–449
Caird FI, Andrews GR, Kennedy RD (1973) Effect of posture on blood pressure in the elderly. Br Heart J 35:527–530
Cooke WH, Reynolds BV, Yandl MG, Carter JR, Tahvanainen KU, Kuusela TA (2002) Effects of exercise training on cardiovagal and sympathetic responses to Valsalva's maneuver. Med Sci Sports Exerc 34:928–935
Davy KP, Willis WL, Seals DR (1997) Influence of exercise training on heart rate variability in post-menopausal women with elevated arterial blood pressure. Clin Physiol 17:31–40
Ebert TJ, Morgan BJ, Barney JA, Denahan T, Smith JJ (1992) Effects of aging on baroreflex regulation of sympathetic activity in humans. Am J Physiol 263:H798–H803
Gribbin B, Pickering TG, Sleight P, Peto R (1971) Effect of age and high blood pressure on baroreflex sensitivity in man. Circ Res 29:424–431
Iellamo F, Legramante JM, Massaro M, Raimondi G, Galante A (2000) Effects of a residential exercise training on baroreflex sensitivity and heart rate variability in patients with coronary artery disease. A randomized, controlled study. Circulation 102:2588–2592
Iellamo F, Legramante JM, Pigozzi F, Spataro A, Norbiato G, Lucini D, Pagani M (2002) Conversion from vagal to sympathetic predominance with strenuous training in high-performance world class athletes. Circulation 105:2719–2724
James MA, Potter JF (1999) Orthostatic blood pressure changes and arterial baroreflex sensitivity in elderly subjects. Age Ageing 28:522–530
Korner PI (1971) Integrative neural cardiovascular control. Physiol Rev 51:312–367
La Rovere MT, Bigger JT Jr, Marcus FI, Mortara A, Schwartz PJ (1998) Baroreflex sensitivity and heart rate variability in prediction of the total cardiac mortality after myocardial infarction. ATRAMI (Autonomic Tone and Reflexes After Myocardial Infarction) Investigators. Lancet 351:478–484
Lipsitz LA, Mietus J, Moody GB, Goldberger AL (1990) Spectral characteristics of heart rate variability before and during postural tilt. Relations to aging and risk of syncope. Circulation 81:1803–1810
Monahan KD, Dinenno FA, Tanaka H, Clevenger CM, DeSouza CA, Seals DR (2000) Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. J Physiol (Lond) 529:263–271
Masaki KH, Schatz IJ, Burchfiel CM, Sharp DS, Chiu D, Foley D, Curb JD (1998) Orthostatic hypotension predicts mortality in elderly men: the Honolulu Heart Program. Circulation 98:2290–2295
Moritani T, Hayashi T, Shinohara M, Mimasa F, Shibata M (1993) Comparison of sympatho-vagal function among diabetic patients, normal, controls, and endurance athletes by heart rate spectral analysis. J Sports Med Sci 7:31–39
Moritani T, Hayashi T, Shinohara M, Mimasa F, Masuda I, Nakao K (1995) Sympatho-vagal activities of NIDDM patients during exercise as determined by heart rate spectral analysis. In: Kawamori R, Vranic M, Horton ES, Kubota M (eds) Glucose fluxes, exercise, and diabetes. Smith-Gordon, London, pp 91–96
Oida E, Moritani T, Yamori Y (1997) Tone-entropy analysis on cardiac recovery after dynamic exercise. J Appl Physiol 82:1794–1801
Oida E, Kannagi T, Moritani T, Yamori Y (1999) Aging alteration of cardiac vagosympathetic balance assessed through the tone-entropy analysis. J Gerontol A Biol Sci Med Sci 54:M219–M224
Paolisso G, Manzella D, Rizzo MR, Barbieri M, Gambardella A, Varricchio M (2000) Effects of glucose ingestion on cardiac autonomic nervous system in healthy centenarians: differences with aged subjects. Eur J Clin Invest 30:277–284
Pawelczyk JA, Raven PB (1989) Reductions in central venous pressure improve carotid baroreflex responses in conscious men. Am J Physiol 257:H1389–H1395
Reiling MJ, Seals DR (1988) Respiratory sinus arrhythmia and carotid baroreflex control of heart rate in endurance athletes and untrained controls. Clin Physiol 8:511–519
Rutan GH, Hermanson B, Bild DE, Kittner SJ, LaBaw F, Tell GS (1992) Orthostatic hypotension in older adults. The Cardiovascular Health Study. CHS Collaborative Research Group. Hypertension Dallas 19:508–519
Seals DR, Chase PB (1989) Influence of physical training on heart rate variability and baroreflex circulatory control. J Appl Physiol 66:1886–1895
Schwartz JB, Gibb WJ, Tran T (1991) Aging effects on heart rate variation. J Gerontol 46:M99–M106
Shannon DC, Carley DW, Benson H (1987) Aging of modulation of heart rate. Am J Physiol 253:H874–H877
Shi X, Wray DW, Formes KJ, Wang HW, Hayes PM, O-Yurvati AH, Weiss MS, Reese IP (2000) Orthostatic hypotension in aging humans. Am J Physiol 279:H1548–H1554
Smith JJ, Ebert TJ (1990) General response to orthostatic stress. Circulatory response to the upright posture. CRC, Boca Raton, pp 1–46
Spina RJ, Bourey RE, Ogawa T, Ehsani AA (1994) Effects of exercise training on alpha-adrenergic mediated pressor responses and baroreflex function in older subjects. J Gerontol 49:B277–B281
Sugiyama Y, Matsukawa T, Inamura K, Zaman AS, Mano T (1995) Arterial baroreflex gain for muscle sympathetic nerve activity during head-up tilting in humans. Environ Med 39:81–84
Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR (2000) Aging, habitual exercise, and dynamic arterial compliance. Circulation 102:1270–1275
Ue H, Masuda I, Yoshitake Y, Inazumi T, Moritani T (2000) Assessment of cardiac autonomic nervous activities by means of ECG R–R interval power spectral analysis and cardiac depolarization-repolarization process. Ann Noninvasive Electrocardiol 5:336–345
Ueno LM, Hamada T, Moritani T (2002) Cardiac autonomic nervous activities and cardiorespiratory fitness in older man. J Gerontol A Biol Sci Med Sci 57:M605–M610
Vroman NB, Healy JA, Kertzer R (1988) Cardiovascular response to lower body negative pressure (LBNP) following endurance training. Aviat Space Environ Med 59:330–334
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This work was in part supported by a Japanese Ministry of Education, Science, Sports and Culture Grant-in-Aid for Scientific Research no. 1148011 to T.M.
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Ueno, L.M., Moritani, T. Effects of long-term exercise training on cardiac autonomic nervous activities and baroreflex sensitivity. Eur J Appl Physiol 89, 109–114 (2003). https://doi.org/10.1007/s00421-002-0777-z
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DOI: https://doi.org/10.1007/s00421-002-0777-z