Abstract
Objective: To examine (1) common types of organic solvent work and prevalent types of solvent used, and (2) possible association of high solvent concentration with types of solvent work and with enterprise size. Methods: The present survey was conducted in Kyoto, Japan, in April 2004 to March 2005. Air samples were collected in 1,010 solvent workplaces (SWPs) (≥5 samples/SWP) in 156 enterprises of various sizes, and analyzed for 47 legally designated organic solvents by flame-ionization detector-equipped gas–liquid chromatography. The geometric mean value of the concentrations (after summation by use of the additiveness formula) in the ≥5 samples were taken as a representative value for the SWP. Solvent works were classified into 11 categories according to the Japanese regulation. Enterprises were classified in terms of number of employees. Results: Degreasing (including cleaning and wiping) was the most common type of solvent work, followed by painting and printing, and toluene was the most often detected solvent (i.e., in 42% of the 1,010 SWPs). Further observation by types of solvent work disclosed that toluene was most common in printing (61%), painting (78%), and adhesive spreading/adhesion SWPs (47%), whereas isopropyl alcohol was the leading solvent in cases of surface coating (51%) and degreasing/cleaning/wiping SWPs (42%). Use of methyl alcohol was also high (36% of all cases). In contrast, use of hexane in adhesives was limited (12%). There was a reverse size-dependency in solvent concentrations in air of SWPs, being five times higher in enterprises with ≤50 employees as compared with the level in enterprises with ≥501 employees. Among SWPs, concentrations tended to be high in printing workplaces especially in small enterprises. In contrast, the levels were much lower in testing and research laboratories irrespective of enterprise size. Comparison with the results in a previous survey in 1996 (Ukai et al. 1997) showed that use of toluene and xylenes was reduced and use of isopropyl alcohol and methyl alcohol was increased. The need of continuous updating of the target analyte list was stressed in relation to the limitation of the present study. Conclusions: Solvent levels were about five times higher in small enterprises as compared with the levels in large enterprises. There was a gradual shift in solvent use from aromatics to other solvents, typically alcohols. The use of hexane in adhesives was reduced. Solvent levels were relatively high in solvent-drying and printing workplaces and low in degreasing/cleaning/wiping workplaces and testing/research laboratories.
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References
Agata T (1997) Fundamental medical statistics (in Japanese). Chuugai Igaku Publishers, Tokyo, pp 114–117
Aksoy M (1985) Benzene as a leukemogenic and carcinogenic agent. Am J Ind Med 8:9–20
American Conference of Governmental Industrial Hygienists (2004) 2005 TLVs® and BEIs®. American Conference of Governmental Industrial Hygienists, Cincinnati
Ana-Lilia G-Y, Carlos K, Kazimierz W, Elva-Leticia P-L, Katarzina W, Gloria B (2005) Occupational exposure to toluene and its possible causative role in renal damage development in shoe workers. Int Arch Occup Environ Health 78:1–6
Anundi H, Lind M-L, Friis L, Itkes N, Langworth S, Edling C (1993) High exposures to organic solvents among graffiti removers. Int Arch Occup Environ Health 65:247–251
Cai S-X, Huang M-Y, Chen Z, Liu Y-T, Jin C, Watanabe T, Nakatsuka H, Seiji K, Inoue O, Ikeda M (1991) Subjective symptom increase among dry-cleaning workers exposed to tetrachloroethylene vapor. Ind Health 29:111–121
Chen R, Seaton A (1996) A meta-analysis of mortality among workers exposed to organic solvents. Occup Med 46:337–344
Cianchetti C, Abbritti G, Perticoni G, Siracusa A, Cuurradi F (1976) Toxic polyneuropathy of shoe-industry workers: a study of 122 cases. J Neurol Neurosurg Psychiat 39:1151–1161
Edling C, Ekberg K, Ahlborg GJr, Alexandersson R, Barregård L, Ekenvall L, Nilsson L, Svensson B G (1990) Long term follow up of workers exposed to solvents. Br J Ind Med 47:75–82
Fleming LE, Shalat SL, Redlich CA (1990) Liver injury in workers exposed to dimethylformamide. Scand J Work Environ Health 16:289–292
Font R, Aracil I, Fullana A, Conesa JA (2004) Semivolatile and volatile compounds in combustion of polyethylene. Chemosphere 37:615–627
Franchini I, Cavatorta A, Falzoi M, Lucertini S, Mutti A (1983) Early indicators of renal damage in workers exposed to organic solvents. Int Arch Occup Environ Health 52:1–9
Government of Japan (1988) Ozone layer protection law (in Japanese). The Government of Japan, Tokyo
Government of Japan (1996a) Air pollution control law, as amended (in Japanese). The Government of Japan, Tokyo
Government of Japan (1996b) Water pollution control law, as amended (in Japanese). The Government of Japan, Tokyo
Government of Japan (2001) Ordinance for occupational health and safety law, as amended (in Japanese). Governmental ordinance No. 78. The Government of Japan, Tokyo
Government of Japan (2002) Occupational health and safety law, as amended (in Japanese). The Government of Japan, Tokyo
Grovers WA, Zellers ET (1996) Investigation of organic vapor losses to condensed water vapor in Tedlar bags used for exhaled-breath sampling. Am Ind Hyg Assoc J 57:257–263
Hoet P, Graf MLM, Bourdi M, Pohl LR, Duray PH, Chen W, Peter RM, Nelson SD, Verlinden N, Lison D (1997) Epidemic of liver disease caused by hydrochlorofluorocarbons used as ozone-sparing substitutes of chlorofluorocarbons. Lancet 350:556–559
Houck P, Nebel D, Milham S (1992) Organic solvent encephalopathy: An old hazard revisited. Am J Ind Med 22:109–115
Huel G, Mergler D, Bowler R (1990) Evidence for adverse reproductive outcomes among women microelectronic assembly workers. Br J Ind Med 47:400–404
Ichihara G, Li W, Ding X, Peng S, Yu X, Shibata E, Yamada T, Wang H, Itohara S, Kanno S, Sakai K, Ito H, Kanefusa K, Takeuchi Y (2004) A survey on exposure level, health status, and biomarkers in workers exposed to 1-bromopropane. Am J Ind Med 45:63–75
Ihrig A, Dietz MC, Bader M, Tribig G (2005) Longitudinal study to explore chronic neuropsychologic effects on solvent exposed workers. Ind Health 43:588–596
Inoue T, Takeuchi Y, Takeuchi S, Yamada S, Suzuki H, Matsushita T, Miyagaki H, Maeda K, Matsumoto T (1970) A health survey of vinyl sandal manufacturers with high incidence of n-hexane intoxication (in Japanese with English abstract). Jpn J Ind Health 12:73–84
Inoue T, Takeuchi Y, Hisanaga N, Ono Y, Iwata M, Ogata M, Saito K, Sakurai H, Hara I, Matsushita T, Ikeda M (1983) A nationwide survey on organic solvent components in various solvent products. 1. Homogeneous products such as thinners, degreasers and reagents. Ind Health 21:175–183
Jang J-Y, Droz P O, Kim S (2001) Biological monitoring of workers exposed to ethylbenzene and co-exposed to xylene. Int Arch Occup Environ Health 74:31–37
Japan Association for Working Environment Measurement (1986) Working environment measurement system in Japan. 3rd edn. Japan Association for Working Environment Measurement, Tokyo
Japan Society for Occupational Health (2005) Recommendation of occupational exposure limits (2005–2006). J Occup Health 47:354–370
Jo W-K, Kim S-H (2001) Worker exposure to aromatic volatile organic compounds in dry cleaning stores. AIHAJ 62:466–471
Kawai T, Takeuchi A, Miyama Y, Sakamoto K, Zhang Z-W, Higashikawa K, Ikeda M (2001) Biological monitoring of occupational exposure to 1-bromopropane by means of urinalysis for 1-bromopropane and bromide ion. Biomarkers 6:303–312
Kim Y, Jung K, Hwang H, Jung G, Kim H, Park J, Kim J, Park J, Park D, Park S, Choi K, Moon Y (1996) Hematopoietic and reproductive hazards of Korean electronic workers exposed to solvents containing 2-bromopropane. Scand J Work Environ Health 22:387–91
Kumagai S, Matsunaga I (1995) Changes in the distribution of short-term exposure concentration with different averaging times. Am Ind Hyg Assoc J 56:24–31
Kumai M, Koizumi A, Saito K, Sakurai H, Inoue T, Takeuchi Y, Hara I, Ogata M, Matsushita T, Ikeda M (1983) A nationwide survey on organic solvent components in various solvent products. 2. Heterogeneous products such as paints, ink and adhesives. Ind Health 21:185–197
Kyoto Industrial Health Association (2004) Workplace survey: detection of chemicals in work environments (in Japanese). KIHA Annu Rep 53:164–168
Lee B-K, Lee S-H, Lee K-M, Cho K-S, Ahn K-D, Kim S-B, Ukai H, Nakatsuka H, Watanabe T, Ikeda M (1988) Dose-dependent increase in subjective symptom prevalence among toluene-exposed workers. Ind Health 26:11–23
Lee Y-L, Pai M-C, Chen J-H, Guo Y L (2003) Central neurological abnormalities and multiple chemical sensitivity caused by chronic toluene exposure. Occup Med 53:479–482
Liu Y-T, Jin C, Chen Z, Cai S-X, Yin S-N, Li G-L, Watanabe T, Nakatsuka H, Seiji K, Inoue O, Kawai T, Ukai H, Ikeda M (1988) Increased subjective symptom prevalence among workers exposed to trichloroethylene at sub-OEL levels. Tohoku J Exp Med 155:183–195
Macaluso M, Delzell E, Rose V, Perkins J (1993) Use of organic solvents and potential worker exposure in the motor vehicle manufacturing industry. Am J Ind Med 23:449–460
Ministry of Health, Labour and Welfare, the Government of Japan (2001a) Ordinance for prevention of health effects due to exposure to designated chemicals, as amended (in Japanese). Ministerial ordinance No. 172. Ministry of Health, Labour and Welfare, Tokyo
Ministry of Health, Labour and Welfare, the Government of Japan (2001b) Standards for evaluation of work environments, as amended (in Japanese). Ministerial notification No. 192. Ministry of Health, Labour and Welfare, Tokyo
Ministry of Health, Labour and Welfare, the Government of Japan (2002a) Standards for measurement of work environments, as amended (in Japanese). Ministerial notification No. 65. Ministry of Health, Labour and Welfare, Tokyo
Ministry of Health, Labour and Welfare, the Government of Japan (2002b) Ordinance for prevention of organic solvent poisoning, as amended (in Japanese). Ministerial ordinance No. 172. Ministry of Health, Labour and Welfare, Tokyo
Ministry of Labour, the Government of Japan (2000) Standards for evaluation of work environments, as amended (in Japanese). Ministerial notification No. 120. Ministry of Labour, Tokyo
Moen BE (1991) Work with chemicals on deck of Norwegian chemical tankers. Int Arch Occup Environ Health 62:543–547
Moen B E, Hollund B E (2000) Exposure to organic solvents among car painters in Bergen, Norway. Ann Occup Hyg 44:185–189
Moon C-S, Lee J-T, Chun J-H, Ikeda M (2001) Use of solvents in industries in Korea; experience in Sinpyeong-Jangrim industrial complex. Int Arch Occup Environ Health 74:148–152
Nelson N A, Robins T G, White R F, Garrison R P (1994) A case-control study of chronic neuropsychiatric disease and organic solvent exposure in automobile assembly plant workers. Occup Environ Med 51:302–307
Piltingsrud H V, Zimmer A. T, Rourke A B (2003) The development of substitute inks and controls for reducing workplace concentrations of organic solvent vapors in a vinyl shower curtain printing plant. Appl Occup Environ Hyg 18:597–619
Purvis K L, Jumba I O, Wandiga S, Zhang J, Kammen D M (2001) Worker exposure and health risks form volatile organic compounds utilized in the paint manufacturing industry of Kenya. Appl Occup Environ Hyg 16:1035–1042
Seedorff L, Olsen E (1990) Exposure to organic solvents. 1. A survey on the use of solvents. Ann Occup Hyg 34:371–378
Takebayashi T, Kabe I, Endo Y, Tanaka S, Miyauchi H, Nozi K, Takahashi K, Omae K (1998) Acute liver dysfunction among workers exposed to 2,2-dchloro-1,1,1-trifluoroethane (HCFC-123): A case report. J Occup Health 40:169–170
Takeuchi Y (1993) n-Hexane polyneuropathy in Japan; a review of n-hexane poisoning and its preventive measures. Environ Res 62:76–80
Takeuchi Y, Ono Y, Hisanaga N (1981) An experimental study on the combined effects of n-hexane and toluene on the peripheral nerve of the rat. Br J Ind Med 38:14–19
Takeuchi Y, Hisanaga N, Ono Y, Shibata E, Saito I, Iwata M (1993) Modification of metabolism and neurotoxicity of hexane by co-exposure of toluene. Int Arch Occup Environ Health 65(Suppl.):S227–S230
Takigawa T, Horike T, Ohashi Y, Kataoka H, Wang D-H, Kira S (2004) Were volatile organic compounds the inducing factors for subjective symptoms of employees working in newly constructed hospitals? Environ Toxicol 19:280–290
Uchida Y, Nakatsuka H, Ukai H, Watanabe T, Liu Y-T, Huang M-Y, Wang Y-L, Zhu F-Z, Yin H, Ikeda M (1993) Symptoms and signs in workers exposed predominantly to xylenes. Int Arch Occup Environ Health 64:597–605
Ukai H, Watanabe T, Nakatsuka H, Satoh T, Liu S-J, Qiao X, Yin H, Jin C, Li G-L, Ikeda M (1993) Dose-dependent increase in subjective symptoms among toluene-exposed workers. Environ Res 60:274–289
Ukai H, Inui S, Takada S, Dendo J, Ogawa J, Isobe K, Ashida T, Tamura M, Tabuki K, Ikeda M (1997) Types of organic solvents used in small- to medium-scale industries in Japan; a nationwide field survey. Int Arch Occup Environ Health 70:385–392
Ukai H, Okamoto S, Takada S, Yamada C, Ikeda M (2004) Lower vapor concentrations in solvent workplaces in larger-scale enterprises than in smaller-scale enterprises, and exceptions. Ind Health 42:252–259
Uksulainen SO, Heikkilä PR, Olkinuora PS, Kiilunen M (2002) Self-reported occupational health hazards and measured exposures to airborne impurities and noise in shoe repair work. Int J Occup Environ Health 8:320–327
Vos J-U, Roller M Brinkmann E, Mangelsdorf I (2005) Nephrotoxicity of organic solvents: biomarkers for early detection. Int Arch Occup Environ Health 78:475–485
Wadden RA, Scheff PA, Franke JE, Conroy LM, Javor M, Keil CB, Milz SA (1995) VOC emission rates and emission factors for a sheetfed offset printing shop. Am Ind Hyg Assoc J 56:368–376
Wallace LA (1991) Personal exposure to 25 volatile organic compounds; EPA’s 1997 team study in Los Angeles, California. Toxicol Ind Health 7:203–208
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Thanks are due to the administration and the staff of Kyoto Industrial Health Association for their interest in and support to this work.
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Samoto, H., Fukui, Y., Ukai, H. et al. Field survey on types of organic solvents used in enterprises of various sizes. Int Arch Occup Environ Health 79, 558–567 (2006). https://doi.org/10.1007/s00420-005-0082-3
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DOI: https://doi.org/10.1007/s00420-005-0082-3