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No consistent risk factor pattern for symptoms related to the sick building syndrome: a prospective population based study

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Abstract

Objectives: To examine associations between perceived indoor environment at work and the non-specific symptoms that are often referred to as the sick building syndrome (SBS), using cross-sectional and prospective analyses for a large cohort from the general population. Methods: The sample comprised 2,164 adults in employment, who completed a postal questionnaire in April 2001. Of these 1,402, who were still working and living in the same place, completed a second questionnaire a year later. The outcome measures were the prevalence of mucous membrane symptoms and general symptoms at baseline and the incidence and persistence of these symptoms at follow-up. Self-reports of the indoor environment from the baseline questionnaire were used as predictors in the analyses. Results: Inconsistent results were found between the cross-sectional and the longitudinal analyses for the associations between perceived indoor environment factors at work and symptoms. Whereas mucous membrane symptoms in the cross-sectional analysis were significantly associated with self-reported high temperature and dry air, the prospective analyses showed that onset of mucous membrane symptoms was associated with the sensation of draught, dry air, and noise. Persistent mucous membrane symptoms were associated only with stuffy air. General symptoms were associated with self-reported stuffy air and dry air in the cross-sectional analysis, while draught was the only predictor of onset of general symptoms. We found no predictors in the indoor environment for the persistence of general symptoms. Conclusions: The symptoms that are often connected with SBS are very common symptoms in the general population among manual workers as well as non-manual workers. Our study gives only limited support to the hypothesis of causal relationships between the indoor environment and these symptoms. We found no evidence of persistent mucous membrane symptoms and general symptoms related to specific factors in the indoor environment.

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References

  • Allison PD (1999) Logistic regression using the SAS® system: theory and application. SAS Institute Inc., Cary, NC

    Google Scholar 

  • Andersen JH, Thomsen JF, Overgaard E, Lassen CF, Brandt LP, Vilstrup I, Kryger AI, Mikkelsen S (2003) Computer use and carpal tunnel syndrome: a 1-year follow-up study. JAMA 289:2963–2969

    Article  PubMed  Google Scholar 

  • Bachmann MO, Myers JE (1995) Influences on sick building syndrome symptoms in three buildings. Soc Sci Med 40:245–251

    Article  PubMed  CAS  Google Scholar 

  • Bjornsson E, Janson C, Norback D, Boman G (1998) Symptoms related to the sick building syndrome in a general population sample: associations with atopy, bronchial hyper-responsiveness and anxiety. Int J Tuberc Lung Dis 2:1023–1028

    PubMed  CAS  Google Scholar 

  • Brauer C (2005) The sick building syndrome revisited. Ph.D. Thesis. Copenhagen University Hospital, Glostrup, Denmark

  • Brauer C, Mikkelsen S (2003) The context of a study influences the reporting of symptoms. Int Arch Occup Environ Health 76:621–624

    Article  PubMed  Google Scholar 

  • Brauer C, Mikkelsen S, Skov P (2000) Reliability and validity of a new questionnaire for investigation of symptoms related to “The Sick Building Syndrome” and perceived indoor air quality [in Danish]. Department of Occupational Medicine, Copenhagen University Hospital, Glostrup, Denmark, Own print

  • Broder I, Pilger C, Corey P (1990) Building related discomfort is associated with perceived rather than measured levels of indoor environmental variables. Indoor Air ‘90, vol 1. Conference Proceeding, pp 221–226

  • Chao HJ, Schwartz J, Milton DK, Burge HA (2003) The work environment and workers’ health in four large office buildings. Environ Health Perspect 111:1242–1248

    PubMed  CAS  Google Scholar 

  • Engelhart S, Burghardt H, Neumann R, Ewers U, Exner M, Kramer MH (1999) Sick building syndrome in an office building formerly used by a pharmaceutical company: a case study. Indoor Air 9:139–143

    Article  PubMed  CAS  Google Scholar 

  • Engvall K, Norrby C, Norback D (2001) Sick building syndrome in relation to building dampness in multi-family residential buildings in Stockholm. Int Arch Occup Environ Health 74:270–278

    Article  PubMed  CAS  Google Scholar 

  • Finnegan MJ, Pickering CA, Burge PS (1984) The sick building syndrome: prevalence studies. Br Med J (Clin Res Ed) 289:1573–1575

    CAS  Google Scholar 

  • Franck C, Bach E, Skov P (1993) Prevalence of objective eye manifestations in people working in office buildings with different prevalences of the sick building syndrome compared with the general population. Int Arch Occup Environ Health 65:65–69

    Article  PubMed  CAS  Google Scholar 

  • Gandek B, Ware JE, Aaronson NK, Apolone G, Bjorner JB, Brazier JE, Bullinger M, Kaasa S, Leplege A, Prieto L, Sullivan M (1998) Cross-validation of item selection and scoring for the SF-12 Health Survey in nine countries: results from the IQOLA Project. International Quality of Life Assessment. J Clin Epidemiol 51:1171–1178

    Article  PubMed  CAS  Google Scholar 

  • Gustafsson J-E (1980) Testing and obtaining fit of data to the Rasch model. Br J Math Stat Psychol 33:205–233

    Google Scholar 

  • Harrison J, Pickering CA, Faragher EB, Austwick PK, Little SA, Lawton L (1992) An investigation of the relationship between microbial and particulate indoor air pollution and the sick building syndrome. Respir Med 86:225–235

    Article  PubMed  CAS  Google Scholar 

  • Hodgson MJ, Morey P, Leung WY, Morrow L, Miller D, Jarvis BB, Robbins H, Halsey JF, Storey E (1998) Building-associated pulmonary disease from exposure to Stachybotrys chartarum and Aspergillus versicolor. J Occup Environ Med 40:241–249

    Article  PubMed  CAS  Google Scholar 

  • Hosmer DW, Lemeshow S (2000) Applied logistic regression. Wiley, New York, NY

    Google Scholar 

  • Johansson SG, Hourihane JO, Bousquet J, Bruijnzeel-Koomen C, Dreborg S, Haahtela T, Kowalski ML, Mygind N, Ring J, van Cauwenberge P, Hage-Hamsten M, Wuthrich B (2001) A revised nomenclature for allergy. An EAACI position statement from the EAACI nomenclature task force. Allergy 56:813–824

    Article  PubMed  CAS  Google Scholar 

  • Karasek R, Theorell T (1990) Healthy work: stress, productivity, and the reconstruction of working life. Basic Books, New York, NY

    Google Scholar 

  • Koskinen OM, Husman TM, Meklin TM, Nevalainen AI (1999) The relationship between moisture or mould observations in houses and the state of health of their occupants. Eur Respir J 14:1363–1367

    Article  PubMed  CAS  Google Scholar 

  • Li CS, Hsu CW, Tai ML (1997) Indoor pollution and sick building syndrome symptoms among workers in day-care centers. Arch Environ Health 52:200–207

    PubMed  CAS  Google Scholar 

  • McDonald JC, Armstrong B, Benard J, Cherry NM, Farant JP (1993) Sick building syndrome in a Canadian office complex. Arch Environ Health 48:298–304

    PubMed  CAS  Google Scholar 

  • Muzi G, Abbritti G, Accattoli MP, dell’Omo M (1998) Prevalence of irritative symptoms in a nonproblem air-conditioned office building. Int Arch Occup Environ Health 71:372–378

    Article  PubMed  CAS  Google Scholar 

  • Nelson NA, Kaufman JD, Burt J, Karr C (1995) Health symptoms and the work environment in four nonproblem United States office buildings. Scand J Work Environ Health 21:51–59

    PubMed  CAS  Google Scholar 

  • Norback D, Edling C (1991) Environmental, occupational, and personal factors related to the prevalence of sick building syndrome in the general population. Br J Ind Med 48:451–462

    PubMed  CAS  Google Scholar 

  • Norback D, Michel I, Widstrom J (1990a) Indoor air quality and personal factors related to the sick building syndrome. Scand J Work Environ Health 16:121–128

    CAS  Google Scholar 

  • Norback D, Torgen M, Edling C (1990b) Volatile organic compounds, respirable dust, and personal factors related to prevalence and incidence of sick building syndrome in primary schools. Br J Ind Med 47:733–741

    CAS  Google Scholar 

  • Nordstrom K, Norback D, Akselsson R (1994) Effect of air humidification on the sick building syndrome and perceived indoor air quality in hospitals: a four month longitudinal study. Occup Environ Med 51:683–688

    Article  PubMed  CAS  Google Scholar 

  • Nordstrom K, Norback D, Akselsson R (1995) Influence of indoor air quality and personal factors on the sick building syndrome (SBS) in Swedish geriatric hospitals. Occup Environ Med 52:170–176

    PubMed  CAS  Google Scholar 

  • Ooi PL, Goh KT, Phoon MH, Foo SC, Yap HM (1998) Epidemiology of sick building syndrome and its associated risk factors in Singapore. Occup Environ Med 55:188–193

    PubMed  CAS  Google Scholar 

  • Reinikainen LM, Jaakkola JJ (2001) Effects of temperature and humidification in the office environment. Arch Environ Health 56:365–368

    Article  PubMed  CAS  Google Scholar 

  • Robertson AS, McInnes M, Glass D, Dalton G, Burge PS (1989) Building sickness, are symptoms related to the office lighting? Ann Occup Hyg 33:47–59

    Article  PubMed  CAS  Google Scholar 

  • Setterlind S, Larsson G (1995) The stress profile: a psychosocial approach to measuring stress. Stress Med 11:85–92

    Article  Google Scholar 

  • Siegrist J (1996) Adverse health effects of high-effort/low-reward conditions. J Occup Health Psychol 1:27–41

    Article  PubMed  CAS  Google Scholar 

  • Skov P, Valbjorn O (1987) The “sick” building syndrome in the office environment: the Danish Town Hall Study. Environ Int 13:339–349

    Article  CAS  Google Scholar 

  • Skov P, Valbjorn O, Pedersen BV (1990) Influence of indoor climate on the sick building syndrome in an office environment. The Danish Indoor Climate Study Group. Scand J Work Environ Health 16:363–371

    CAS  Google Scholar 

  • Streiner DL (1994) Figuring out factors: the use and misuse of factor analysis. Can J Psychiatry 39:135–140

    PubMed  CAS  Google Scholar 

  • Sundell J, Lindvall T, Stenberg B, Wall S (1994) Sick building syndrome (SBS) in office workers and facial skin syndromes among VDT-workers in relation to building and room characteristics: two case-referent studies. Indoor Air 4:83–94

    Article  Google Scholar 

  • Tang SK (1997) Performance of noise indices in air-conditioned landscaped office buildings. J Acoust Soc Am 102:1657–1663

    Article  PubMed  CAS  Google Scholar 

  • Toftum J (2004) Air movement—good or bad? Indoor Air 14(Suppl 7):40–45

    Article  PubMed  Google Scholar 

  • U.S. Environmental Protection Agency (1991) Indoor air quality and work environment study: EPA headquarters building, vol III: relating employee responses to the follow-up questionnaire with environmental measurements of indoor air quality. U.S. Environmental Protection Agency, NC, USA

  • Wan GH, Li CS (1999) Dampness and airway inflammation and systemic symptoms in office building workers. Arch Environ Health 54:58–63

    PubMed  CAS  Google Scholar 

  • World Health Organization (1983) Indoor air pollutants: exposure and health effects—report on a WHO meeting, vol 78. WHO Regional Office for Europe. EURO Reports and Studies 78, pp1–48

  • Zweers T, Preller L, Brunekreef B, Boleij JSM (1992) Health and indoor climate complaints of 7043 office workers in 61 buildings in the Netherlands. Indoor Air 2:127–136

    Article  Google Scholar 

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Acknowledgements

This study received financial support from The Danish Working Environment Council and the Danish Medical Research Council.

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Authors and Affiliations

  1. Department of Occupational Medicine, Copenhagen University Hospital, Glostrup, Denmark

    Charlotte Brauer & Sigurd Mikkelsen

  2. Department of Occupational Medicine, Aarhus University Hospital, Aarhus, Denmark

    Henrik Kolstad

  3. National Institute of Occupational Health, Copenhagen, Denmark

    Palle Ørbæk

  4. Arbejdsmedicinsk Klinik, Amtssygehuset i Glostrup, Nordre Ringvej 57, 2600, Glostrup, Denmark

    Charlotte Brauer

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  1. Charlotte Brauer
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  2. Henrik Kolstad
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  3. Palle Ørbæk
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  4. Sigurd Mikkelsen
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Correspondence to Charlotte Brauer.

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Brauer, C., Kolstad, H., Ørbæk, P. et al. No consistent risk factor pattern for symptoms related to the sick building syndrome: a prospective population based study. Int Arch Occup Environ Health 79, 453–464 (2006). https://doi.org/10.1007/s00420-005-0074-3

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  • DOI: https://doi.org/10.1007/s00420-005-0074-3

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