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Exposure to air pollution and pulmonary function in university students

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Abstract

Objectives: Exposure to air pollution has been reported to be associated with increase in pulmonary disease. The aims of the present study were to examine the use of personal nitrogen dioxide (NO2) samplers as a means of measuring exposure to air pollution and to investigate the relationship between personal exposure to air pollution and pulmonary function. Methods: We measured individual exposures to NO2 using passive personal NO2 samplers for 298 healthy university students. Questionnaire interview was conducted for traffic-related factors, and spirometry was performed when the samplers were returned after 1 day. Results: Personal NO2 concentrations varied, depending on the distance between residence and a main road (P=0.029). Students who used transportation for more than 1 h were exposed to higher levels of NO2 than those using transportation for less than 1 h (P=0.032). In terms of transportation, riding in a bus or subway caused significantly higher exposure than not using them (P=0.046). NO2 exposure was not significantly associated with forced vital capacity (FVC) or forced expiratory volume in 1 s (FEV1) but was associated with the ratio of FEV1/FVC and mid-expiratory flow between 25% and 75% of the forced vital capacity (FEF25–75) (P<0.05). Conclusions: This study indicates that concentrations of personal exposure to NO2 are significantly influenced by traffic-related air pollution and are associated with decreased pulmonary function.

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References

  • Ackermann-Liebrich U, Leuenberger P, Schwartz J, Schindler C, Monn C, Bolognini G, Bongard JP, Brandli O, Domenighetti G, Elsasser S, Grize L, Karrer W, Keller R, Keller-Wossidlo H, Kunzli N, Martin BW, Medici TC, Perruchoud AP, Schoni MH, Tschopp JM, Villiger B, Wuthrich B, Zellweger JP, Zemp E (1997) Lung function and long term exposure to air pollutants in Switzerland. Study on Air Pollution and Lung Diseases in Adults (SAPALDIA) Team. Am J Respir Crit Care Med 155:122–129

    Google Scholar 

  • Allegra L, Moavero NE, Rampoldi C (1991) Ozone-induced impairment of mucociliary transport and its prevention with N-acetylcysteine. Am J Med 91:67S–71S

    Article  Google Scholar 

  • Blomberg A, Krishna MT, Helleday R, Soderberg M, Ledin MC, Kelly FJ, Frew AJ, Holgate ST, Sandstrom T (1999) Persistent airway inflammation but accommodated antioxidant and lung function responses after repeated daily exposure to nitrogen dioxide. Am J Respir Crit Care Med 159:536–543

    Google Scholar 

  • Brunekreef B, Janssen NA, de Hartog J, Harssema H, Knape M, van Vliet P (1997) Air pollution from truck traffic and lung function in children living near motorways. Epidemiology 8:298–303

    Google Scholar 

  • Bush T, Smith S, Stevenson K, Moorcroft S (2001) Validation of nitrogen dioxide diffusion tube methodology in the UK. Atmos Environ 35:289–296

    Google Scholar 

  • Carr D, von Ehrenstein O, Weiland S, Wagner C, Wellie O, Nicolai T, von Mutius E (2002) Modeling annual benzene, toluene, NO2, and soot concentrations on the basis of road traffic characteristics. Environ Res 90:111–118

    Google Scholar 

  • Dennekamp M, Howarth S, Dick CA, Cherrie JW, Donaldson K, Seaton A (2001) Ultrafine particles and nitrogen oxides generated by gas and electric cooking. Occup Environ Med 58:511–516

    Google Scholar 

  • Frampton MW, Morrow PE, Cox C, Gibb FR, Speers DM, Utell MJ (1991) Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans. Am Rev Respir Dis 143:522–527

    Google Scholar 

  • Frampton MW, Boscia J, Roberts NJ Jr, Azadniv M, Torres A, Cox C, Morrow PE, Nichols J, Chalupa D, Frasier LM, Gibb FR, Speers DM, Tsai Y, Utell MJ (2002) Nitrogen dioxide exposure: effects on airway and blood cells. Am J Physiol Lung Cell Mol Physiol 282:L155–L165

    Google Scholar 

  • Garcia-Aymerich J, Tobias A, Anto JM, Sunyer J (2000) Air pollution and mortality in a cohort of patients with chronic obstructive pulmonary disease: a time series analysis. J Epidemiol Community Health 54:73–74

    Article  Google Scholar 

  • Gauderman WJ, McConnell R, Gilliland F, London S, Thomas D, Avol E, Vora H, Berhane K, Rappaport EB, Lurmann F, Margolis HG, Peters J (2000) Association between air pollution and lung function growth in southern California children. Am J Respir Crit Care Med 162:1383–1390

    Google Scholar 

  • Gauderman WJ, Gilliland GF, Vora H, Avol E, Stram D, McConnell R, Thomas D, Lurmann F, Margolis HG, Rappaport EB, Berhane K, Peters JM (2002) Association between air pollution and lung function growth in southern California children: results from a second cohort. Am J Respir Crit Care Med 166:76–84

    Article  Google Scholar 

  • Gehring U, Cyrys J, Sedlmeir G, Brunekreef B, Bellander T, Fischer P, Bauer CP, Reinhardt D, Wichmann HE, Heinrich J (2002) Traffic-related air pollution and respiratory health during the first 2 years of life. Eur Respir J 19:690–698

    Article  Google Scholar 

  • Hangartner M (1998) One year intercomparison study of NO2 diffusive samplers in Switzerland. In: The Diffusive Monitor, issue 10

  • Hasselblad V, Eddy DM, Kotchmar DJ (1992) Synthesis of environmental evidence: nitrogen dioxide epidemiology studies. J Air Waste Manage Assoc 42:662–671

    Google Scholar 

  • Hayes GB, Christiani DC (1993) Measures of small airways disease as predictors of chronic obstructive pulmonary disease. Occup Med 8:375–395

    Google Scholar 

  • Hoek G, Brunekreef B (1994) Effects of low-level winter air pollution concentrations on respiratory health of Dutch children. Environ Res 64: 136–150

    Google Scholar 

  • Hoek G, Brunekreef B, Goldbohm S, Fischer P, van den Brandt PA (2002) Association between mortality and indicators of traffic-related air pollution in the Netherlands: a cohort study. Lancet 360:1203–1209

    Article  Google Scholar 

  • Hong YC, Leem JH, Ha EH, Christiani DC (1999) PM(10) exposure, gaseous pollutants, and daily mortality in Incheon, South Korea. Environ Health Perspect 107:873–878

    Google Scholar 

  • Hwang JS, Chan CC (2002) Effects of air pollution on daily clinic visits for lower respiratory tract illness. Am J Epidemiol 155:1–10

    Article  Google Scholar 

  • Kodama Y, Arashidani K, Tokui N, Kawamoto T, Matsuno K, Kunugita N, Minakawa N (2002) Environmental NO2 concentration and exposure in daily life along main roads in Tokyo. Environ Res 89:236–244

    Google Scholar 

  • Kramer U, Koch T, Ranft U, Ring J, Behrendt H (2000) Traffic-related air pollution is associated with atopy in children living in urban areas. Epidemiology 11:64–70

    Article  PubMed  Google Scholar 

  • McConnell R, Berhane K, Gilliland F, London SJ, Vora H, Avol E, Gauderman WJ, Margolis HG, Lurmann F, Thomas DC, Peters JM (1999) Air pollution and bronchitic symptoms in Southern California children with asthma. Environ Health Perspect 107:757–760

    Google Scholar 

  • Muller B, Seifart C, Barth PJ (1998) Effect of air pollutants on the pulmonary surfactant system. Eur J Clin Invest 28:762–777

    Article  Google Scholar 

  • Muller B, Oske M, Hochscheid R, Seifart C, Barth PJ, Garn H, von Wichert P (2001) Effect of N-acetylcysteine treatment on NO2-impaired type II pneumocyte surfactant metabolism. Eur J Clin Invest 31:179–188

    Article  Google Scholar 

  • Oosting RS, van Greevenbroek MM, Verhoef J, van Golde LM, Haagsman HP (1991) Structural and functional changes of surfactant protein A induced by ozone. Am J Physiol 261:L77–L83

    Google Scholar 

  • Persinger RL, Blay WM, Heintz NH, Hemenway DR, Janssen-Heininger YM (2001) Nitrogen dioxide induces death in lung epithelial cells in a density-dependent manner. Am J Respir Cell Mol Biol 24:583–590

    Google Scholar 

  • Peters JM, Avol E, Gauderman WJ, Linn WS, Navidi W, London SJ, Margolis H, Rappaport E, Vora H, Gong H Jr, Thomas DC (1999) A study of twelve Southern California communities with differing levels and types of air pollution. II. Effects on pulmonary function. Am J Respir Crit Care Med 159:768–775

    Google Scholar 

  • Rijnders E, Janssen NA, van Vliet PH, Brunekreef B (2001) Personal and outdoor nitrogen dioxide concentrations in relation to degree of urbanization and traffic density. Environ Health Perspect 109 [Suppl 3]:411–417

    Google Scholar 

  • Stevenson K, Bush T, Diane M (2001) Five years of nitrogen dioxide measurement with diffusion tube samplers at over 1000 sites in the UK. Atmos Environ 35:281–287

    Google Scholar 

  • van der Vliet A, Cross CE (2000) Oxidants, nitrosants, and the lung. Am J Med 109:398–421

    Article  Google Scholar 

  • van Vliet P, Knape M, de Hartog J, Janssen N, Harssema H, Brunekreef B (1997) Motor vehicle exhaust and chronic respiratory symptoms in children living near freeways. Environ Res 74:122–132

    Google Scholar 

  • Zhu Y, Hinds WC, Kim S, Sioutas C (2002) Concentration and size distribution of ultrafine particles near a major highway. J Air Waste Manag Assoc 52:1032–1042

    Google Scholar 

Download references

Acknowledgments

This study was supported by grant 02-PJ1-PG1-CH03-0001 of the Department of Health and Welfare, South Korea.

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Correspondence to Yun-Chul Hong.

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Hong, YC., Leem, JH., Lee, KH. et al. Exposure to air pollution and pulmonary function in university students. Int Arch Occup Environ Health 78, 132–138 (2005). https://doi.org/10.1007/s00420-004-0554-x

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  • DOI: https://doi.org/10.1007/s00420-004-0554-x

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