Abstract
· Background: Sarcoidosis is a multisystemic granulomatous disease of unknown etiology, while Lyme borreliosis is a multisystemic disorder caused by Borrelia burgdorferi. The purpose of this study is to evaluate the relationship between sarcoidosis and Lyme borreliosis in a region of Japan where Lyme borreliosis is endemic. · Methods: We determined the seroprevalence of anti-Borrelia burgdorferi antibodies as well as antibodies three Japanese Borrelia strains by enzyme-linked immunosorbent assay and dotblot assay using purified Borrelia-specific proteins in 46 patients with confirmed sarcoidosis and 150 controls (50 disease controls and 100 healthy controls) in Hokkaido, the affected region. · Results: Fifteen patients with sarcoidosis (32.6%) tested positive for Borrelia spirochete in both assays, compared with two disease controls (4.0%) and two healthy controls (2.0%). The seroprevalence of anti-Borrelia antibodies in patients with sarcoidosis was much higher in the affected region than in the region in our previous study where Lyme borreliosis is non-endemic. · Conclusion: In a region where Lyme borreliosis is endemic, Borrelia infection may be partially associated with sarcoidosis.
Similar content being viewed by others
Author information
Authors and Affiliations
Additional information
Received: 27 May 1997 Revised version received: 18 August 1997 Accepted: 9 September 1997
Rights and permissions
About this article
Cite this article
Ishihara, M., Ohno, S., Ono, H. et al. Seroprevalence of anti-Borrelia antibodies among patients with confirmed sarcoidosis in a region of Japan where Lyme borreliosis is endemic. Graefe's Arch Clin Exp Ophthalmol 236, 280–284 (1998). https://doi.org/10.1007/s004170050078
Issue Date:
DOI: https://doi.org/10.1007/s004170050078