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The role of choriocapillaris vessel density in the pathogenesis of macular neovascularization associated with choroidal osteoma

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Abstract

Purpose

To detect the vessel density of choriocapillaris (CC) vascular network in eyes affected by choroidal osteoma and in eyes complicated by macular neovascularization (MNV), using optical coherence tomography angiography (OCTA).

Methods

In this retrospective study, twenty-eight eyes of 28 patients were divided into three groups: group 1 including patients with calcified choroidal osteoma, group 2 including patients with decalcified choroidal osteoma, and group 3 including patients with decalcified choroidal osteoma complicated by MNV. OCTA analyzed the vessel density of CC in these lesions localized in the peripapillary region.

Results

We enrolled 12 eyes with calcified choroidal osteoma, 11 eyes with decalcified choroidal osteoma, and 5 eyes with decalcified choroidal osteoma complicated by MNV. The eyes with decalcified choroidal osteoma and MNV revealed a statistically significant reduction in vessel density of the CC respect to the other groups (p < 0.001). Moreover, the vessel density of CC in decalcified choroidal osteoma was significantly reduced compared to calcified choroidal osteoma (p < 0.001).

Conclusions

OCTA allowed a quantitative evaluation of choriocapillaris vessel density in choroidal osteoma, in order to detect the changes of this vascular network, which could lead to the development of MNV. Therefore, OCTA could be a new diagnostic tool in the clinical management of the choroidal osteoma.

Clinical trial registration

ClinicalTrials.gov Identifier: NCT05342324.

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Authors and Affiliations

  1. Department of Neurosciences, Reproductive and Odontostomatological Sciences, Federico II University, Naples, Italy

    Gilda Cennamo, Giuseppe Iacucci, Maria Angelica Breve, Daniela Montorio, Claudio Xompero & Ciro Costagliola

  2. Eye Clinic, Public Health Department, University of Naples Federico II, Naples, Italy

    Gilda Cennamo

Authors
  1. Gilda Cennamo
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  2. Giuseppe Iacucci
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  3. Maria Angelica Breve
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  4. Daniela Montorio
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  5. Claudio Xompero
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  6. Ciro Costagliola
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Corresponding author

Correspondence to Gilda Cennamo.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of the University of Naples “Federico II” and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Cennamo, G., Iacucci, G., Breve, M.A. et al. The role of choriocapillaris vessel density in the pathogenesis of macular neovascularization associated with choroidal osteoma. Graefes Arch Clin Exp Ophthalmol 261, 1283–1287 (2023). https://doi.org/10.1007/s00417-022-05921-1

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  • DOI: https://doi.org/10.1007/s00417-022-05921-1

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