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Choroidal morphologic features in central serous chorioretinopathy using ultra-widefield optical coherence tomography

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To analyze the choroidal morphological changes in central serous chorioretinopathy (CSC) using ultra-widefield (UWF)-optical coherence tomography (OCT).

Methods

This single-center, case–control study included 65 CSC eyes (52 males; age, 55.6 ± 13.0 years) and 65 healthy eyes (50 males; age, 57.1 ± 17.9 years). UWF-OCT (viewing angle, 200°) with real-shape correction was used to create an automated choroidal thickness (CT) map. The CT map had three sub-areas: the central (0–30°), middle (30–60°), and peripheral areas (60–100°), and was divided by vertical and horizontal lines. Differences in the CT and the CT change rate (CTCR) from the central to peripheral areas were examined between the CSC and control groups after adjusting for subjects’ demographic and clinical factors. Furthermore, we assessed the vortex veins dilation patterns (VVDP) in the macula and examined the CT and the CTCR differences between CSC patients and controls for each VVDP.

Results

CSC patients had greater CT than those of the controls in all sectors (CSC vs. controls, the peripheral area: supratemporal 284.4 ± 71.2 μm vs. 220.4 ± 71.2 μm, infratemporal 263.3 ± 69.2 μm vs. 195.3 ± 52.3 μm, supranasal 251.9 ± 70.3 μm vs. 189.5 ± 58.1 μm, infranasal 193.6 ± 71.2 μm vs. 146.3 ± 48.9 μm, P < 0.0001 for all sectors). The CTCR was apparently larger in CSC eyes than controls only for the upper-dominant type of VVDP (CSC patients vs. controls, supratemporal 32.1 ± 9.9% vs. 4.6 ± 23.1%, infratemporal 44.0 ± 11.2% vs. 25.6 ± 16.8%, supranasal 42.6 ± 9.8% vs. 22.2 ± 19.4%, infranasal 57.6 ± 41.2% vs. 41.2 ± 13.9%, P < 0.0001 for all sectors).

Conclusions

CSC has a thicker choroid, even in the peripheral areas, and the macular choroidal thickening was more severe in the upper-dominant type of VVDP. VVDP may affect the location of excessive fluid.

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Acknowledgements

We are grateful to the orthoptists Masatoshi Tomita, Kikuko Toyodome, and the staff at the Kagoshima University Hospital for their support in the data collection process. We would like to thank Editage (www.editage.com) for English language editing.

Funding

This study was supported by JSPS KAKENHI (grant number 21H03095).

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan

    Ryoh Funatsu, Shozo Sonoda, Hiroto Terasaki, Hideki Shiihara, Naohisa Mihara & Taiji Sakamoto

  2. Canon Inc., Tokyo, Japan

    Juun Horie

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  1. Ryoh Funatsu
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  2. Shozo Sonoda
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  3. Hiroto Terasaki
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  7. Taiji Sakamoto
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Contributions

Conception of design and conduct: RF, SS, HT, HS, NM, JH, TS, acquisition of the data: RF, NM, JH, management of data: RF, SS, NM, analysis of data: RF, SS, HS, JH, interpretation of the results: RF, SS, HT, HS, NM, JH, TS, preparation of articles: RF, HT, TS, and review and approval of the manuscript: RF, SS, HT, HS, NM, JH, TS.

Corresponding author

Correspondence to Taiji Sakamoto.

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Ethics approval

This study was approved by the ethics committee of Kagoshima University, Kagoshima, Japan (No.16012). All the procedures were conducted in accordance with the tenets of the Declaration of Helsinki.

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No conflicting relationships exist for any author.

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Funatsu, R., Sonoda, S., Terasaki, H. et al. Choroidal morphologic features in central serous chorioretinopathy using ultra-widefield optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 261, 971–979 (2023). https://doi.org/10.1007/s00417-022-05905-1

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