Skip to main content

Advertisement

SpringerLink
Log in

Characteristics of glaucoma patients with intraocular pressure elevation early after trabectome surgery

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To analyze the rate and time of occurrence of intraocular pressure (IOP) elevation early after trabectome surgery (TOM) and the characteristics of glaucoma patients recovering from IOP elevation.

Method

Four hundred sixty eyes of 460 glaucoma (191 primary and 269 secondary open-angle glaucoma) patients who underwent TOM were evaluated. IOP elevation early after TOM was diagnosed when IOP increased by more than 5 mmHg over baseline within 1 week to 3 months. If the IOP decreased with the administration of anti-glaucoma eye drops alone, patients were classified as recovered. If the IOP did not decrease despite additional anti-glaucoma eye drop use, patients were classified as non-recovered. The rate and time of occurrence of IOP elevation early after TOM were investigated. Demographic and ocular variables related to recovery and non-recovery were identified by multivariate logistic regression analysis.

Results

Of the 460 patients, IOP elevation early after TOM occurred in 102 (22.2%). IOP elevation occurred most frequently at postoperative week 1. Of the 102 patients with IOP elevation, 55 (53.9%) recovered and 47 (46.1%) did not. A large hyphema size the day after surgery was associated with increased likelihood of recovery from IOP elevation (odds ratio [OR], 6.6). A history of past selective laser trabeculoplasty (SLT; OR, 0.10) and high baseline IOP (OR, 0.86) were associated with reduced likelihood of recovery from IOP elevation.

Conclusion

IOP elevation early after TOM occurred most frequently at postoperative week 1. Patients with a large hyphema size, no history of SLT, and a lower baseline IOP recovered from IOP elevation early after TOM. A large hyphema the day after surgery suggested an increased likelihood of recovery from IOP elevation.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Minckler D, Baerveldt G, Ramirez MA, Mosaed S, Wilson R, Shaarawy T, Zack B, Dustin L, Francis B (2006) Clinical results with the trabectome, a novel surgical device for treatment of open-angle glaucoma. Trans Am Ophthalmol Soc 104:40–50

    PubMed  PubMed Central  Google Scholar 

  2. Kaplowitz K, Bussel II, Honkanen R, Schuman JS, Loewen NA (2016) Review and meta-analysis of ab-interno trabeculectomy outcomes. Br J Ophthalmol 100:594–600. https://doi.org/10.1136/bjophthalmol-2015-307131

    Article  PubMed  Google Scholar 

  3. Lavia C, Dallorto L, Maule M, Ceccarelli M, Fea AM (2017) Minimally-invasive glaucoma surgeries (MIGS) for open angle glaucoma: a systematic review and meta-analysis. PLoS ONE 12:e0183142. https://doi.org/10.1371/journal.pone.0183142

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Kasahara M, Shoji N (2020) Effectiveness and limitations of minimally invasive glaucoma surgery targeting Schlemm’s canal. Jpn J Ophthalmol. https://doi.org/10.1007/s10384-020-00781-w(inpress)

    Article  PubMed  Google Scholar 

  5. Kono Y, Kasahara M, Hirasawa K, Tsujisawa T, Kanayama S, Matsumura K, Morita T, Shoji N (2020) Long-term clinical results of trabectome surgery in patients with open-angle glaucoma. Graefes Arch Clin Exp Ophthalmol 258:2467–2476. https://doi.org/10.1007/s00417-020-04897-0

    Article  PubMed  Google Scholar 

  6. Ahuja Y, Ma Khin Pyi S, Malihi M, Hodge DO, Sit AJ (2013) Clinical results of ab interno trabeculotomy using the trabectome for open-angle glaucoma: the Mayo Clinic series in Rochester, Minnesota. Am J Ophthalmol 156:927-935.e922. https://doi.org/10.1016/j.ajo.2013.06.001

    Article  PubMed  Google Scholar 

  7. Minckler D, Mosaed S, Dustin L, Francis B, Trabectome Study Group (2008) Trabectome (trabeculectomy-internal approach): additional experience and extended follow-up. Trans Am Ophthalmol Soc 106:149–159

  8. Kuusniemi A-M, Lindbohm N, Allinen P, Koskinen M, Harju M (2020) Ab interno trabeculotomy: key prognostic factors. J Glaucoma 29:211–216. https://doi.org/10.1097/IJG.0000000000001432

    Article  PubMed  Google Scholar 

  9. Mizoguchi T, Nishigaki S, Sato T, Wakiyama H, Ogino N (2015) Clinical results of trabectome surgery for open-angle glaucoma. Clin Ophthalmol 9:1889–1894. https://doi.org/10.2147/opth.S83958

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Esfandiari H, Shah P, Torkian P, Conner IP, Schuman JS, Hassanpour K, Loewen NA (2019) Five-year clinical outcomes of combined phacoemulsification and trabectome surgery at a single glaucoma center. Graefes Arch Clin Exp Ophthalmol 257:357–362. https://doi.org/10.1007/s00417-018-4146-y

    Article  PubMed  Google Scholar 

  11. Jea SY, Francis BA, Vakili G, Filippopoulos T, Rhee DJ (2012) Ab interno trabeculectomy versus trabeculectomy for open-angle glaucoma. Ophthalmology 119:36–42. https://doi.org/10.1016/j.ophtha.2011.06.046

    Article  PubMed  Google Scholar 

  12. King AJ, Fernie G, Azuara-Blanco A, Burr JM, Garway-Heath T, Sparrow JM, Vale L, Hudson J, MacLennan G, McDonald A, Barton K, Norrie J (2018) Treatment of advanced Glaucoma study: a multicentre randomised controlled trial comparing primary medical treatment with primary trabeculectomy for people with newly diagnosed advanced glaucoma-study protocol. Br J Ophthalmol 102:922–928. https://doi.org/10.1136/bjophthalmol-2017-310902

    Article  PubMed  Google Scholar 

  13. Sofi RA, Shafi S, Qureshi W, Ashraf S (2018) Merits of trabeculectomy in advanced and end-stage glaucoma. Int J Health Sci (Qassim) 12:57–60

    Google Scholar 

  14. Shoji N, Kasahara M, Iijima A, Takahashi M, Tatsui S, Matsumura K, Morita T, Shimizu K (2016) Short-term evaluation of trabectome surgery performed on Japanese patients with open-angle glaucoma. Jpn J Ophthalmol 60:156–165. https://doi.org/10.1007/s10384-016-0433-5

    Article  CAS  PubMed  Google Scholar 

  15. Ting JL, Damji KF, Stiles MC (2012) Ab interno trabeculectomy: outcomes in exfoliation versus primary open-angle glaucoma. J Cataract Refract Surg 38:315–323. https://doi.org/10.1016/j.jcrs.2011.08.043

    Article  PubMed  Google Scholar 

  16. Jea SY, Mosaed S, Vold SD, Rhee DJ (2012) Effect of a failed trabectome on subsequent trabeculectomy. J Glaucoma 21:71–75. https://doi.org/10.1097/IJG.0b013e31820bcfda

    Article  PubMed  Google Scholar 

  17. Weiner Y, Severson ML, Weiner A (2015) Intraocular pressure 3 to 4 hours and 20 hours after cataract surgery with and without ab interno trabeculectomy. J Cataract Refract Surg 41:2081–2091. https://doi.org/10.1016/j.jcrs.2015.10.048

    Article  PubMed  Google Scholar 

  18. Lam D, Lee J, Leung E, Liu S, Yuan J, Ratra V (2018) Non-self-sealing (Leaky) anterior chamber paracentesis: a new technique in managing postphacoemulsification intraocular pressure rise in glaucoma and normal eyes. Asia Pac J Ophthalmol (Phila) 7:284–287. https://doi.org/10.22608/apo.2016213

    Article  Google Scholar 

  19. Grzybowski A, Kanclerz P (2019) Early postoperative intraocular pressure elevation following cataract surgery. Curr Opin Ophthalmol 30:56–62. https://doi.org/10.1097/icu.0000000000000545

    Article  PubMed  Google Scholar 

  20. Rosenquist R, Epstein D, Melamed S, Johnson M, Grant WM (1989) Outflow resistance of enucleated human eyes at two different perfusion pressures and different extents of trabeculotomy. Curr Eye Res 8:1233–1240. https://doi.org/10.3109/02713688909013902

    Article  CAS  PubMed  Google Scholar 

  21. Johnstone MA (2016) Glaucoma research and clinical advances 2016 to 2018. In: Knepper PA, Samples JR (eds) Intraocular pressure control through linked trabecular meshwork and collector channel motion, 1st edn. Kugler Publications, Amsterdam, pp 44–85

  22. Francis BA, See RF, Rao NA, Minckler DS, Baerveldt G (2006) Ab interno trabeculectomy: development of a novel device (trabectome) and surgery for open-angle glaucoma. J Glaucoma 15:68–73. https://doi.org/10.1097/01.ijg.0000196653.77836.af

    Article  PubMed  Google Scholar 

  23. Harms H, Dannheim R (1970) Trabeculotomy–results and problems. Bibl Ophthalmol 81:121–131

    CAS  PubMed  Google Scholar 

  24. Inatani M, Tanihara H, Muto T, Honjo M, Okazaki K, Kido N, Honda Y (2001) Transient intraocular pressure elevation after trabeculotomy and its occurrence with phacoemulsification and intraocular lens implantation. Jpn J Ophthalmol 45:288–292. https://doi.org/10.1016/s0021-5155(01)00322-7

    Article  CAS  PubMed  Google Scholar 

  25. Latina MA, Park C (1995) Selective targeting of trabecular meshwork cells: in vitro studies of pulsed and CW laser interactions. Exp Eye Res 60:359–371. https://doi.org/10.1016/s0014-4835(05)80093-4

    Article  CAS  PubMed  Google Scholar 

  26. Alon S (2013) Selective laser trabeculoplasty: a clinical review. J Curr Glaucoma Pract 7:58–65. https://doi.org/10.5005/jp-journals-10008-1139

    Article  PubMed  PubMed Central  Google Scholar 

  27. Gedde SJ, Herndon LW, Brandt JD, Budenz DL, Feuer WJ, Schiffman JC, Tube Versus Trabeculectomy Study G (2012) Postoperative complications in the Tube Versus Trabeculectomy (TVT) study during five years of follow-up. Am J Ophthalmol 153:804-814.e801. https://doi.org/10.1016/j.ajo.2011.10.024

    Article  Google Scholar 

  28. Yamamoto T, Sawada A, Mayama C, Araie M, Ohkubo S, Sugiyama K, Kuwayama Y (2014) The 5-year incidence of bleb-related infection and its risk factors after filtering surgeries with adjunctive mitomycin C: collaborative bleb-related infection incidence and treatment study 2. Ophthalmology 121:1001–1006. https://doi.org/10.1016/j.ophtha.2013.11.025

    Article  PubMed  Google Scholar 

Download references

Funding

This study was supported by a research fund at Kitasato University.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kitasato University School of Medicine, 1-15-1 Kitasato, Minami, Sagamihara, Kanagawa, 252-0374, Japan

    Yusuke Kono, Masayuki Kasahara, Kazunori Hirasawa, Kazuhiro Matsumura, Tetsuya Morita & Nobuyuki Shoji

  2. Machida Matsumura Eye Clinic, Tokyo, Japan

    Kazuhiro Matsumura

  3. Morita Eye Clinic, Tokyo, Japan

    Tetsuya Morita

Authors
  1. Yusuke Kono
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Masayuki Kasahara
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kazunori Hirasawa
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kazuhiro Matsumura
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Tetsuya Morita
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Nobuyuki Shoji
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Nobuyuki Shoji.

Ethics declarations

Conflict of interest

The authors declare no competing interests.

Ethics approval

This study does not contain any studies with animals performed by any of the authors.

Informed consent

Informed consent was obtained from all participants.

Study approval

This study was approved by the Institutional Review Board of Kitasato University.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Kono, Y., Kasahara, M., Hirasawa, K. et al. Characteristics of glaucoma patients with intraocular pressure elevation early after trabectome surgery. Graefes Arch Clin Exp Ophthalmol 260, 537–543 (2022). https://doi.org/10.1007/s00417-021-05355-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-021-05355-1

Keywords

Search

Navigation