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Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography

  • Glaucoma
  • Published:
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Abstract

Background/aims

To evaluate diurnal variations in optic nerve head (ONH) vessel density assessed by optical coherence tomography angiography (OCT-A) in healthy subjects, ocular hypertension (OHT), and open-angle glaucoma (OAG) patients.

Methods

Forty subjects (OAG, 21; OHT, 6; healthy, 13) were assessed for vessel density percentage (VD%) and flow index in the ONH (NH VD%, NH index), and in the radial peripapillary capillary layer (RPC VD%, RPC index) at 9:00, 11:00, 14:00, 16:00, and 18:00 on a single day. Repeated measures ANOVAs were used to test for changes in the parameters measured at multiple time points.

Results

All OCT-A parameters analyzed at the different time points were statistically lower in the OAG patients compared to both the OHT and healthy groups (p < 0.05). In the OAG group, the NH index, RPC index, NH VD%, and RPC VD% were statistically lower at 18:00 compared to 14:00, and the RPC VD% was statistically lower at 9:00 than 14:00. In the OHT group, the RPC index was statistically lower at 9:00 than 11:00. In the healthy group, the NH VD% and RPC VD% were statistically lower at 16:00 than 18:00, and the RPC index was statistically lower at 9:00 than 11:00. No other statistically significant difference was found in none of the three groups comparing any other time point (p > 0.05).

Conclusion

In healthy subjects, OHT and OAG patients, the variations in the OCT-A derived parameters were relatively small. These results suggest that in the clinical practice the OCT-A assessment can be performed independently of the time of the day, contrasting IOP evaluation.

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Funding

The contribution of the author/s Francesco Oddone, Lucia Tanga, Ivano Riva, and Alice C. Verticchio Vercellin was supported by Fondazione Roma and by the Italian Ministry of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. All the other authors received no specific funding for this work.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, University of Pavia, Pavia, Italy

    Alice C. Verticchio Vercellin & Luciano Quaranta

  2. IRCCS - Fondazione Bietti, Rome, Italy

    Alice C. Verticchio Vercellin, Lucia Tanga, Ivano Riva & Francesco Oddone

  3. Department of Ophthalmology, Ophthalmic Vascular Diagnostic and Research Program at Mount Sinai Hospital, Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, Annenberg 22-86, New York, NY, 10029, USA

    Alice C. Verticchio Vercellin, Alon Harris & Brent Siesky

  4. Ophthalmology, Indiana University School of Medicine, Indianapolis, IN, USA

    Lucas W. Rowe & Rana Torabi

  5. Ophthalmology Clinic, Department of Medicine and Aging Science, University G. d’Annunzio of Chieti-Pescara, Chieti, Italy

    Luca Agnifili

Authors
  1. Alice C. Verticchio Vercellin
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  2. Alon Harris
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Corresponding author

Correspondence to Alon Harris.

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Competing interests

The authors declare that they have no competing interests.

Ethics statement

The study protocol was approved by the Ethical Committee of the IRCCS, Fondazione G.B. Bietti, Rome, Italy. All patients signed an informed consent prior to initiation of this study, which adhered to the tenets of the Declaration of Helsinki.

Financial disclosure

Dr. Alon Harris would like to disclose that he receives remuneration from AdOM for serving as a consultant and board member, and from Thea for a speaking engagement. Dr. Harris also holds an ownership interest in AdOM, Luseed, Oxymap, and QuLent. None of the other authors listed have any financial disclosures.

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Verticchio Vercellin, A.C., Harris, A., Tanga, L. et al. Optic nerve head diurnal vessel density variations in glaucoma and ocular hypertension measured by optical coherence tomography angiography. Graefes Arch Clin Exp Ophthalmol 258, 1237–1251 (2020). https://doi.org/10.1007/s00417-020-04635-6

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  • DOI: https://doi.org/10.1007/s00417-020-04635-6

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