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Association between optic nerve head morphology in open-angle glaucoma and corneal biomechanical parameters measured with Corvis ST

  • Glaucoma
  • Published:
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Abstract

Purposes

To investigate associations between Corvis ST-measured corneal biomechanical parameters and glaucomatous optic nerve head (ONH) morphology.

Methods

In total, 118 eyes of 70 patients with open-angle glaucoma were examined in this retrospective cross-sectional study. We measured Heidelberg retina tomograph and Corvis ST values in all eyes. We used the linear mixed model in four sectors (temporal superior, TS; temporal inferior, TI; nasal superior, NS; and nasal inferior, NI) to detect associations between six ONH-related parameters and 14 Corvis ST–related parameters, controlling for age, intraocular pressure, axial length, and central corneal thickness. We calculated the ONH temporal and nasal sector vertical asymmetries (TS-TI and NS-NI asymmetries) and identified the optimal linear mixed models to describe them using model selection with the second-order bias corrected Akaike Information Criterion.

Results

The Corvis ST A2 velocity was negatively associated with the rim volume in the NS sector (p < 0.05). The optimal model for TS-TI asymmetry was TS-TI asymmetry = − 3.22 + 0.15 × HC time + 0.88 × HC deflection amplitude, whereas that for NS-NI asymmetry was 0.49–0.048 × axial length − 2.45 × A2 velocity.

Conclusion

Glaucomatous ONH superior-inferior asymmetries were associated with biomechanical properties measured with Corvis ST. Eyes with superior-dominant rim volume reduction of ONH were associated with small deformations and slow recovery of the cornea.

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Acknowledgments

This research was (partially) supported by The Translational Research program; Strategic Promotion for practical application of Innovative medical Technology, TR-SPRINT, from the Japan Agency for Medical Research and Development, AMED, Grants 18KK0253 and 17 K11418 from the Ministry of Education, Culture, Sports, Science, and Technology of Japan and Japan Science and Technology Agency (JST) CREST JPMJCR1304.

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Authors and Affiliations

  1. Department of Ophthalmology, Sapporo City General Hospital, Sapporo, Japan

    Shuichiro Aoki

  2. Department of Ophthalmology and Visual Science, Hiroshima University, Hiroshima, Japan

    Yoshiaki Kiuchi & Kana Tokumo

  3. Department of Ophthalmology, University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Yuri Fujino, Masato Matsuura, Hiroshi Murata & Ryo Asaoka

  4. Department of Rehabilitation, Orthopic and Visual Science, School of Allied Health Sciences, Kitasato University, Tokyo, Kanagawa, Japan

    Yuri Fujino & Masato Matsuura

  5. Department of Ophthalmology, Saneikai Tsukazaki Hospital, Himeji, Hyogo, Japan

    Shunsuke Nakakura

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  1. Shuichiro Aoki
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Contributions

Shuichiro Aoki, Yoshiaki Kiuchi, Shunsuke Nakakura, and Ryo Asaoka contributed to the study conception and design. Material preparation, data collection, and analysis were performed by Shuichiro Aoki, Yoshiaki Kiuchi, Kana Tokumo, Yuri Fujino, Masato Matsuura, Hiroshi Murata, and Ryo Asaoka. The first draft of the manuscript was written by Shuichiro Aoki. All authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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Correspondence to Ryo Asaoka.

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Aoki, S., Kiuchi, Y., Tokumo, K. et al. Association between optic nerve head morphology in open-angle glaucoma and corneal biomechanical parameters measured with Corvis ST. Graefes Arch Clin Exp Ophthalmol 258, 629–637 (2020). https://doi.org/10.1007/s00417-019-04572-z

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  • DOI: https://doi.org/10.1007/s00417-019-04572-z

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