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Detection of serum anti-retinal antibodies in the Chinese patients with presumed autoimmune retinopathy

  • Inflammatory Disorders
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Abstract

Purpose

To explore the presence of serum anti-retinal antibodies (ARAs) in the Chinese patients with presumed autoimmune retinopathy (AIR).

Methods

Twenty-three Chinese patients with presumed AIR, disease controls including 40 RP patients, 22 bilateral uveitis patients, 18 acute zonal outer occult retinopathy (AZOOR) patients, and 30 healthy donors were included. Serum samples of all the subjects were obtained and analyzed for the presence of four ARAs including recoverin, α-enolase, carbonic anhydraseII (CAII), and collapsin response-mediated protein (CRMP)-5 by Western bolt assay.

Results

ARAs were present in the serum of either presumed AIR patients, disease control, or healthy donors. One or more ARAs were present in the 78.2% of presumed AIR while they were indicated in the 35.0% of RP patients (p < 0.01) and 33.3% of healthy donors (p < 0.01). The prevalence of ARAs in the bilateral uveitis and AZOOR was 63.3% and 100% respectively. Positive rate of α-enolase antibody present in the presumed AIR, disease control, and healthy donors was 73.9%, 47.5%, and 33.3% respectively. Positive rate of CAII antibody present above groups was 52.1%, 50%, and 33.3% respectively. Recoverin antibody seemed to be specifically present in the serum of patients with cancer-associated retinopathy.

Conclusion

Presence of serum ARAs including recoverin, α-enolase, CAII, or CRMP-5 in the Chinese patients with presumed AIR occurred significantly more often than RP patients and healthy donors. Seropositivity of ARAs had diagnostic value for the presumed AIR but mere presence was not sufficient for the diagnosis due to identification of them in the healthy controls and other retinal diseases.

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Funding

This work was supported by Beijing Municipal Health System High-level Professionals training Program 2015.

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Author notes

  1. Hui-yang Zeng and Qian Liu contributed equally to this work and should be regarded as equivalent first authors.

Authors and Affiliations

  1. Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, 1 Dongjiaominxiang Road, Dongchen District, Beijing, 100730, People’s Republic of China

    Hui-yang Zeng, Qian Liu, Xiao-yan Peng, Kai Cao, Shan-shan Jin & Ke Xu

  2. Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijng, 100730, China

    Hui-yang Zeng, Qian Liu, Xiao-yan Peng, Kai Cao, Shan-shan Jin & Ke Xu

Authors
  1. Hui-yang Zeng
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  2. Qian Liu
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  3. Xiao-yan Peng
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  4. Kai Cao
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  5. Shan-shan Jin
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Correspondence to Hui-yang Zeng.

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The authors declare that they have no conflict of interest.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Zeng, Hy., Liu, Q., Peng, Xy. et al. Detection of serum anti-retinal antibodies in the Chinese patients with presumed autoimmune retinopathy. Graefes Arch Clin Exp Ophthalmol 257, 1759–1764 (2019). https://doi.org/10.1007/s00417-019-04359-2

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  • DOI: https://doi.org/10.1007/s00417-019-04359-2

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