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Optical coherence tomography angiography in retinal vein occlusions

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To examine the vascular density in different retinal layers and in the choriocapillaris in eyes with retinal vein occlusions (RVO).

Methods

Applying optical coherence tomography angiography (OCTA), we examined patients with unilateral RVOs and normal individuals of a control group.

Results

The study group included 48 patients with unilateral RVO and the control group 17 normal individuals. Eyes affected by RVO as compared to the contralateral unaffected eyes (all P < 0.001), and the contralateral unaffected eyes as compared to the eyes of the control group (P < 0.05), showed a lower vessel density in the superficial and deep retinal layers in all regions except for the foveal region. Choriocapillaris density was lower (P < 0.001), foveal retinal thickness and subfoveal choroidal thickness (P < 0.001) were thicker, and the foveal avascular zone was larger (P = 0.003) in the RVO eyes than in the contralateral eyes. For 29 eyes undergoing OCTA and fluorescein angiography, two examiners independently rated the retinas to be ischemic in fluorescein angiography in 14 eyes and in OCTA in 9 of these 14 eyes.

Conclusions

Upon OCTA, unaffected eyes of patients with unilateral RVOs showed vascular abnormalities in the superficial and deep retinal layers when compared to those of healthy individuals.

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Funding

The Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support (code: ZYLX201307), the National Natural Science Foundation of China (Nr. 81272981), the Beijing Natural Science Foundation (Nr. 7151003), the Advanced Health Care Professionals Development Project of Beijing Municipal Health Bureau (No. 2014-2-003), and the priming scientific research foundation for the junior research in Beijing Tongren Hospital Capital Medical University (2017-YJJ-ZZL-009) provided financial support.

Author information

Author notes

  1. Qian Wang and Szy Yann Chan contributed equally to the work and share the first authorship.

Authors and Affiliations

  1. Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, and Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Hospital, Capital Medical University, Beijing, China

    Qian Wang, Yanni Yan, Jingyan Yang, Wenjia Zhou & Wen Bin Wei

  2. Department of Ophthalmology, Peking University Third Hospital, Beijing, China

    Szy Yann Chan

  3. Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karis-University Heidelberg, Kutzerufer 1, 68167, Mannheim, Germany

    Jost B. Jonas

Authors
  1. Qian Wang
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  2. Szy Yann Chan
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  3. Yanni Yan
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  4. Jingyan Yang
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  5. Wenjia Zhou
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  6. Jost B. Jonas
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  7. Wen Bin Wei
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Corresponding authors

Correspondence to Jost B. Jonas or Wen Bin Wei.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by the Medical Ethics Committee of the Beijing Tongren Hospital, and written informed consent was obtained from all study participants, and all methods were performed in accordance with the relevant guidelines and regulations.

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Wang, Q., Chan, S.Y., Yan, Y. et al. Optical coherence tomography angiography in retinal vein occlusions. Graefes Arch Clin Exp Ophthalmol 256, 1615–1622 (2018). https://doi.org/10.1007/s00417-018-4038-1

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  • DOI: https://doi.org/10.1007/s00417-018-4038-1

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