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Does the disruption of horizontal anterior ciliary vessels affect the blood–aqueous barrier function?

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Abstract

Purpose

To investigate the significance of the anterior ciliary vessels (ACVs) preservation during the conventional horizontal strabismus surgery.

Methods

Patients (≥ 8 years) with horizontal strabismus were randomly allocated into group 1 (with ACV preservation) and group 2 (without ACV preservation). The surgical eyes in group 1 were further divided into group A (one rectus muscle operated) and group B (two rectus muscles operated). Similarly, eyes in group 2 were divided into group C (one rectus muscle operated) and group D (two rectus muscles operated). The success rate of ACV preservation was calculated. The anterior chamber flare measurements of each eye by laser flare photometry were recorded on the day prior to and after operation. The flare values between groups and between pre- and post-operation in each group were compared by one-way analysis of variance and a paired t-test respectively.

Results

In groups A and B, the success rate of ACV preservation was 82% (27/33) and 70% (28/40)respectively, and the flare values between pre- and post-operation showed no significant differences(4.378 ± 1.527, 4.544 ± 1.452, P = 0.526; 4.625 ± 1.090, 4.989 ± 1.468, P = 0.101 respectively). However, the postoperative values were significantly increased in group C and group D(4.661 ± 1.031, 5.039 ± 1.310, P = 0.025; 4.933 ± 1.691, 5.502 ± 1.430, P = 0.000 respectively). The postoperative flare readings of group D were significantly higher than group B, while group A and group C had no significant variation.

Conclusion

ACV preservation probably has clinical significance in reducing the undesirable influence on the blood–aqueous barrier.

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Funding

The Department of Science and Technology of Fujian province provided financial support in the form of the Science and Technology Project of Fujian Province (Grant No. 2016D007, Website: http://xmgl.fjkjt.gov.cn/p_itemsearch.pr.pr_itemsearch.do#), China.

The sponsor had no role in the design or conduct of this research.

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Authors and Affiliations

  1. Xiamen Eye center of Xiamen University, Xiamen, 361000, People’s Republic of China

    Meihua Pan, Mei Yang, Renyi Xie, Zhimin Zhao & Xingxing Huang

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  1. Meihua Pan
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  2. Mei Yang
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  3. Renyi Xie
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  4. Zhimin Zhao
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  5. Xingxing Huang
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Correspondence to Meihua Pan.

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Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Pan, M., Yang, M., Xie, R. et al. Does the disruption of horizontal anterior ciliary vessels affect the blood–aqueous barrier function?. Graefes Arch Clin Exp Ophthalmol 255, 2451–2457 (2017). https://doi.org/10.1007/s00417-017-3807-6

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  • DOI: https://doi.org/10.1007/s00417-017-3807-6

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