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Pre-papillary vitreous opacities associated with Behçet’s disease: a case series and review of the literature

  • Inflammatory Disorders
  • Published:
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Abstract

Purpose

To present pre-papillary vitreous opacity as an uncommon manifestation of inflammation in Behçet’s disease that may be specific to this uveitic entity.

Methods

We retrospectively reviewed the charts of 67 patients with Behçet’s disease examined at our clinic between 2005 and 2016. Behçet’s disease was diagnosed based on established clinical criteria of inflammation involving the eyes, mucocutaneous junctions, and skin. Patients with Behçet’s disease who presented with papillitis and a pre-papillary vitreous opacity were identified. Response to anti-inflammatory treatment on examination and optical coherence tomography imaging were evaluated. PubMed searches were performed for (1) other cases with pre-papillary vitreous opacities in uveitic entities and (2) reports of optic nerve involvement specifically in Behçet’s disease.

Results

We identified three patients with Behçet’s disease who presented with unilateral papillitis and a pre-papillary vitreous opacity. The pre-papillary vitreous opacity had a funnel-shaped appearance on optical coherence tomography. All patients were initially treated with steroids, which led to resolution of the opacity clinically and on imaging. We identified one previous report of such a pre-papillary opacity in a patient with Behçet’s disease, and no reports of this finding in other uveitic entities.

Conclusion

This study expands the number of Behçet’s disease cases presenting with a pre-papillary vitreous opacity and demonstrates novel optical coherence imaging of this finding. This finding may be specific to Behçet’s disease as it was not identified in other uveitic entities in a review of the existing literature.

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Authors and Affiliations

  1. Harvard Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, 243 Charles Street, Boston, MA, 02114, USA

    Lindsay A. Grotting, Samaneh Davoudi, George N. Papaliodis & Lucia Sobrin

  2. Retina Group of Florida, Fort Lauderdale, FL, USA

    Eduardo Uchiyama

  3. University of Illinois, Illinois Eye and Ear Infirmary, Chicago, IL, USA

    Ann-Marie Lobo

Authors
  1. Lindsay A. Grotting
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  2. Samaneh Davoudi
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  3. Eduardo Uchiyama
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  4. Ann-Marie Lobo
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  5. George N. Papaliodis
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  6. Lucia Sobrin
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Corresponding author

Correspondence to Lucia Sobrin.

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Funding

This study was not funded by any grants or sources.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest or non-financial interest in the subject matter or materials discussed in this manuscript.

Ethical approval

All procedures performed in this study were in accordance with the ethical standards of the Massachusetts Eye and Ear Infirmary Institutional Review Board and with the 1964 Helsinki declaration and its later amendments.

Informed consent

The requirement for informed consent was waived by the Institutional Review Board for this retrospective chart review.

Additional information

This submission has not been published anywhere previously and is not simultaneously being considered for any other publication.

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Grotting, L.A., Davoudi, S., Uchiyama, E. et al. Pre-papillary vitreous opacities associated with Behçet’s disease: a case series and review of the literature. Graefes Arch Clin Exp Ophthalmol 255, 2017–2021 (2017). https://doi.org/10.1007/s00417-017-3741-7

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  • DOI: https://doi.org/10.1007/s00417-017-3741-7

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