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Optical coherence tomography manifestations of primary vitreoretinal lymphoma

  • Retinal Disorders
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Abstract

Background

Primary vitreoretinal lymphoma (PVRL), a subset of primary central nervous system lymphoma (PCNSL), is a high-grade malignant tumor that shows various chorioretinal findings. Optical coherence tomography (OCT) is useful for detecting these lesions, and various abnormalities on OCT images have been reported. The purpose of this report was to investigate retrospectively the OCT manifestations of various disease stages and compare the manifestations of pretreatment, recurrent, and chronic cases.

Methods

We reviewed the medical charts and OCT images of 38 consecutive cases with PVRL. When abnormalities were detected on OCT images, the patients were classified based on the treatment of the primary disease: pretreatment if not treated, recurrent if treated previously, and chronic when chronic changes.

Results

Twenty-six eyes (20 cases) had abnormalities in the post-pole OCT images, i.e., 16 eyes (12 cases) were in the pretreatment group, seven eyes (five cases) were in the recurrent group, and five eyes (five cases) were in the chronic group. Two eyes (two cases) had abnormalities on OCT in the pretreatment and recurrent or chronic stages. The pretreatment and recurrent groups had subretinal or retinal pigment epithelium (RPE) level abnormalities more often than intraretinal changes. Twelve of 16 pretreated eyes and all seven eyes with recurrent disease had subretinal or RPE level abnormalities. One pretreatment case and three recurrent cases had atypical OCT manifestations of intraretinal (round lesions) or epiretinal changes (villous-shaped lesions).

Conclusions

Although pretreatment cases and recurrent cases showed similar OCT abnormalities and the specific changes in the various disease stages were unclarified, collecting OCT data from various disease stages will facilitate detection of typical OCT changes of PVRL and lead to early diagnosis and treatment.

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Authors and Affiliations

  1. Department of Ophthalmology, Japan Community Health Care Organization Osaka Hospital, 4-2-78, Fukushima, Fukushima-ku, Osaka City, 553-0003, Japan

    Teiko Saito & Nobuyuki Ohguro

  2. Department of Ophthalmology, Osaka University Medical School, 2-2 Yamadaoka E7, Suita, Osaka, 565-0871, Japan

    Nobuyuki Ohguro, Chiharu Iwahashi & Noriyasu Hashida

Authors
  1. Teiko Saito
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  2. Nobuyuki Ohguro
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  3. Chiharu Iwahashi
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  4. Noriyasu Hashida
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Corresponding author

Correspondence to Nobuyuki Ohguro.

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The authors declare that they have no conflicts of interest.

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No funding was received for this research.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Saito, T., Ohguro, N., Iwahashi, C. et al. Optical coherence tomography manifestations of primary vitreoretinal lymphoma. Graefes Arch Clin Exp Ophthalmol 254, 2319–2326 (2016). https://doi.org/10.1007/s00417-016-3395-x

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  • DOI: https://doi.org/10.1007/s00417-016-3395-x

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