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ABCA1 rs1883025 polymorphism and risk of age-related macular degeneration

  • Genetics
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the association of the ABCA1 rs1883025 polymorphism and susceptibility to age-related macular degeneration (AMD).

Methods

A systematic search of the PubMed, EMBASE, and ISI web of science databases was performed to identify eligible published studies without language restrictions up to September 2015. Pooled odds ratios (ORs) with 95 % confidence intervals (CIs) were estimated under different genetic models using meta-analytic methods. Stratified analysis and sensitivity analysis were performed to explore potential sources of heterogeneity.

Results

A total of 12 articles with 25,445 cases and 36,460 controls were eligible in this meta-analysis. The ABCA1 rs1883025 variant showed significant association with the lower risk of overall AMD under the allelic model (OR= 0.81, 95   %   CI=0.74–0.89). Stratified analysis based on ethnicity demonstrated a strong association between rs1883025 polymorphism and AMD in the Caucasian population, but not in Asian population. For late AMD, the ABCA1 rs1883025 variant was observed to have a significant association with the lower risk of this disease (OR = 0.81, 95 % CI, 0.72–0.91). In early-stage AMD, significant associations of the rs1883025 polymorphism with lower risk of early AMD were observed in different genetic models (OR ranging from 0.45 to 0.65, all P < 0.05).

Conclusions

The present meta-analysis indicated that the T allelic in rs1883025 variant was significantly associated with the risk of developing AMD, particularly at the early stage. The associations of the ABCA1 locus with AMD risk in various populations need further exploration.

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Author notes

    Authors and Affiliations

    1. School of Public Health, Xi’an Jiao tong University Health Science Center, 76 Yanta West Road, Xi’an, Shaanxi, 710061, China

      Yafeng Wang, Mingxu Wang, Yue Han, Rui Zhang & Le Ma

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    1. Yafeng Wang
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    2. Mingxu Wang
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    3. Yue Han
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    4. Rui Zhang
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    5. Le Ma
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    Correspondence to Le Ma.

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    Funding

    NSFC provided financial support in the form of the National Natural Science Foundation of China (NSFC-81202198, NSFC-81473059). The sponsor had no role in the design or conduct of this research.

    Conflict of interest

    All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge, or beliefs) in the subject matter or materials discussed in this manuscript.

    Ethical approval and informed consent

    All analyses were based on previous published studies, thus no ethical approval and patient consent are required.

    Additional information

    Yafeng Wang and Mingxu Wang contributed equally to this work.

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    Wang, Y., Wang, M., Han, Y. et al. ABCA1 rs1883025 polymorphism and risk of age-related macular degeneration. Graefes Arch Clin Exp Ophthalmol 254, 323–332 (2016). https://doi.org/10.1007/s00417-015-3211-z

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    • DOI: https://doi.org/10.1007/s00417-015-3211-z

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