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Correlation of SD-OCT findings and visual function in patients with retinitis pigmentosa

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To describe the morphological macular changes detected by spectral domain optical coherence tomography (SD-OCT) in eyes with retinitis pigmentosa (RP) and to analyze their correlation with the visual function.

Methods

Twenty-two patients (44 eyes) patients affected by RP were recruited. The following structures were evaluated on SD-OCT: outer plexiform layer (OPL), outer nuclear layer (ONL), external limiting membrane (ELM), photoreceptor inner/outer segment (IS/OS) junction, photoreceptor outer segment/retinal pigmented epithelium (OS/RPE) junction, inner limiting membrane thickening (ILMT), ganglion cell complex (GCC), and cystoid macular edema (CME). The relation between each SD-OCT finding and BCVA was evaluated at uni- and multivariate analysis.

Results

Mean age and mean best-corrected visual acuity (BCVA) were 51 ± 17.5 years and 0.4 ± 0.5 LogMAR, respectively. Univariate linear regression model revealed a correlation between BCVA and the absence of ELM, IS/OS, ONL, and OS/RPE layers (R 2 values were, respectively, 0.51, 0.57, 0.48, and 0.68, with p values all <0.0001). At multivariate regression analysis, the absence of OS/RPE and ELM layers remained the only variables independently associated with a decrease of BCVA (R 2 = 0.85, t = 3.49, p = 0.0014).

Conclusions

Data show that in patients afflicted with RP, ELM and OS/RPE layers are independently associated with BCVA on multivariate regression analysis. These results highlight the key-role of external retinal layers in determining the visual function impairment attributable to RP.

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Authors and Affiliations

  1. Department of Ophthalmology, University Vita-Salute, San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy

    Maurizio Battaglia Parodi, Carlo La Spina, Giacinto Triolo, Luisa Pierro, Marco Gagliardi & Francesco Bandello

  2. Ordine Mauriziano Hospital, Turin, Italy

    Fulvio Riccieri

Authors
  1. Maurizio Battaglia Parodi
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  2. Carlo La Spina
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  3. Giacinto Triolo
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  4. Fulvio Riccieri
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  5. Luisa Pierro
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  6. Marco Gagliardi
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  7. Francesco Bandello
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Corresponding author

Correspondence to Carlo La Spina.

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Funding

No funding was received for this research.

Conflict of interest

All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria; educational grants; participation in speakers’ bureaus; membership, employment, consultancies, stock ownership, or other equity interest; and expert testimony or patent-licensing arrangements), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

Financial disclosures

Dr. Bandello F:

Advisory Board Member: ALLERGAN, INC.; NOVARTIS PHARMACEUTICALS CORPORATION; FARMILA-THEA; BAYER SCHERING PHARMA; PFIZER, INC.; ALCON, INC.; BAUSCH AND LOMB; GENENTECH, INC.; ALIMERA SCIENCES, INC; THROMBOGENICS, INC.

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For this type of study formal consent is not required.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Battaglia Parodi, M., La Spina, C., Triolo, G. et al. Correlation of SD-OCT findings and visual function in patients with retinitis pigmentosa. Graefes Arch Clin Exp Ophthalmol 254, 1275–1279 (2016). https://doi.org/10.1007/s00417-015-3185-x

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  • DOI: https://doi.org/10.1007/s00417-015-3185-x

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