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Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy

  • Neurophthalmology
  • Published:
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Abstract

Purpose

The aim of the study was to evaluate the relationship between visual function and retinal nerve fiber layer thickness (RNFLT) determined using Stratus optical coherence tomography (OCT) in patients with autosomal dominant optic atrophy (ADOA).

Methods

The study was a retrospective, institutional, and comparative case series. Thirty-six consecutive patients with ADOA and 72 age-matched normal controls were compared with regard to RNFLT, best-corrected visual acuity (BCVA), and visual field.

Results

The relative reduction of RNFLT of ADOA patients was most evident in the temporal quadrant (56.8 %), followed by the inferior (35.5 %), superior (27.2 %), and nasal quadrants (26.4 %). In ADOA patients, BCVA decreased with RNFL thinning (p < 0.001), and was not related to age (p = 0.210). Papillomacular bundle RNFLT decreased with age throughout the study period of 3.7 ± 2.3 years (−3.83 ± 9.96 μm, p = 0.017). The presence of a superotemporal central scotoma (61.1 %) was related to decreased inferotemporal RNFLT (7 and 8 o’clock, p = 0.016 and p = 0.036, respectively).

Conclusions

The papillomacular bundle RNFL of ADOA is most vulnerable and progressively damaged with age, despite early temporal RNFL loss. Early loss of inferior temporal RNFL in ADOA is related to superotemporal central scotoma.

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Acknowledgments

None of the authors have any financial interests to disclose.

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Authors and Affiliations

  1. Department of Ophthalmology, Seoul National University College of Medicine, Seoul, Korea

    Sung Wook Park & Jeong-Min Hwang

  2. Department of Biomedical Science, Seoul National University College of Medicine, Seoul, Korea

    Sung Wook Park

  3. Department of Ophthalmology, Seoul National University Bundang Hospital, Seongnam, Korea

    Jeong-Min Hwang

  4. Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, 166 Gumiro, Bundang-gu, Seongnam, Gyeonggi-do, 463-707, South Korea

    Jeong-Min Hwang

Authors
  1. Sung Wook Park
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  2. Jeong-Min Hwang
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Correspondence to Jeong-Min Hwang.

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Park, S.W., Hwang, JM. Optical coherence tomography shows early loss of the inferior temporal quadrant retinal nerve fiber layer in autosomal dominant optic atrophy. Graefes Arch Clin Exp Ophthalmol 253, 135–141 (2015). https://doi.org/10.1007/s00417-014-2852-7

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  • DOI: https://doi.org/10.1007/s00417-014-2852-7

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