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Macular ganglion cell–inner plexiform layer thinning in patients with visual field defect that respects the vertical meridian

  • Neurophthalmology
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Abstract

The aim of this work is to compare the thinning patterns of the ganglion cell inner-plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) as measured using Cirrus high-definition optical coherence tomography (HD-OCT) in patients with visual field (VF) defects that respect the vertical meridian. Twenty eyes of 11 patients with VF defects that respect the vertical meridian were enrolled retrospectively. The thicknesses of the macular GCIPL and pRNFL were measured using Cirrus HD-OCT. The 5 and 1 % thinning area index (TAI) was calculated as the proportion of abnormally thin sectors at the 5 and 1 % probability level within the area corresponding to the affected VF. The 5 and 1 % TAI were compared between the GCIPL and pRNFL measurements. The color-coded GCIPL deviation map showed a characteristic vertical thinning pattern of the GCIPL, which is also seen in the VF of patients with brain lesions. The 5 and 1 % TAI were significantly higher in the GCIPL measurements than in the pRNFL measurements (all p < 0.01). Macular GCIPL analysis clearly visualized a characteristic topographic pattern of retinal ganglion cell (RGC) loss in patients with VF defects that respect the vertical meridian, unlike pRNFL measurements. Macular GCIPL measurements provide more valuable information than pRNFL measurements for detecting the loss of RGCs in patients with retrograde degeneration of the optic nerve fibers.

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Authors and Affiliations

  1. Department of Ophthalmology, Uijeongbu St. Mary’s Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea

    Hye-Young Shin

  2. Department of Ophthalmology and Visual Science, Seoul St. Mary’s Hospital, College of Medicine, Catholic University of Korea, 505 Banpo-dong, Seocho-ku, Seoul, South Korea

    Hae-Young Lopilly Park & Chan Kee Park

  3. Department of Ophthalmology, St. Vincent Hospital, College of Medicine, Catholic University of Korea, Seoul, South Korea

    Jin-A Choi

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  1. Hye-Young Shin
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  2. Hae-Young Lopilly Park
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  3. Jin-A Choi
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  4. Chan Kee Park
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Correspondence to Chan Kee Park.

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No author has received any financial support or has a financial interest in any materials or method mentioned in this work.

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Shin, HY., Park, HY.L., Choi, JA. et al. Macular ganglion cell–inner plexiform layer thinning in patients with visual field defect that respects the vertical meridian. Graefes Arch Clin Exp Ophthalmol 252, 1501–1507 (2014). https://doi.org/10.1007/s00417-014-2706-3

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  • DOI: https://doi.org/10.1007/s00417-014-2706-3

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