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Relationship between foveal microstructures and visual outcomes in eyes with resolved central serous chorioretinopathy

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To determine whether significant correlations exist between the foveal microstructures and visual outcomes in eyes with resolved central serous chorioretinopathy (CSC).

Methods

We retrospectively reviewed the medical records of patients who had a complete resolution of the serous retinal detachment (SRD) and had an intact ellipsoid zone in the fovea in the spectral-domain optical coherence tomographic (SD-OCT) images. Twenty-five eyes with CSC (CSC group) and 18 unaffected fellow eyes (control group) of 23 patients were evaluated. The eyes in the CSC group were divided into those with (n = 11) and those without (n = 14) visual disturbances after resolution of the SRD. The thickness of each retinal layer at the fovea was measured in the SD-OCT images.

Results

The photoreceptor outer segment (OS) length in the CSC group was significantly shorter than that in the control group (p = 0.0003). In addition, the photoreceptor OS length in the visual disturbances group was significantly shorter and the duration of SRD was significantly longer than that in the no visual disturbances group (p = 0.0230, p = 0.0021, respectively).

Conclusions

The photoreceptor OS length is a good parameter to indicate the integrity of the foveal photoreceptors in eyes with a resolved CSC.

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References

  1. Gass JD (1967) Pathogenesis of disciform detachment of the neuroepithelium. Am J Ophthalmol 63:1–139

    PubMed  Google Scholar 

  2. Spaide RF, Hall L, Haas A, Campeas L, Yannuzzi LA, Fisher YL, Guyer DR, Slakter JS, Sorenson JA, Orlock DA (1996) Indocyanine green videoangiography of older patients with central serous chorioretinopathy. Retina 16:203–213

    Article  CAS  PubMed  Google Scholar 

  3. Klein ML, Van Buskirk EM, Friedman E, Gragoudas E, Chandra S (1974) Experience with nontreatment of central serous choroidopathy. Arch Ophthalmol 91:247–250

    Article  CAS  PubMed  Google Scholar 

  4. Yap EY, Robertson DM (1996) The long-term outcome of central serous chorioretinopathy. Arch Ophthalmol 114:689–692

    Article  CAS  PubMed  Google Scholar 

  5. Iida T, Yannuzzi LA, Spaide RF, Borodoker N, Carvalho CA, Negrao S (2003) Cystoid macular degeneration in chronic central serous chorioretinopathy. Retina 23:1–7

    Article  PubMed  Google Scholar 

  6. Ficker L, Vafidis G, While A, Leaver P (1988) Long-term follow-up of a prospective trial of argon laser photocoagulation in the treatment of central serous retinopathy. Br J Ophthalmol 72:829–834

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  7. Chan WM, Lam DS, Lai TY, Tam BS, Liu DT, Chan CK (2003) Choroidal vascular remodelling in central serous chorioretinopathy after indocyanine green guided photodynamic therapy with verteporfin: a novel treatment at the primary disease level. Br J Ophthalmol 87:1453–1458

    Article  PubMed Central  PubMed  Google Scholar 

  8. Gilbert CM, Owens SL, Smith PD, Fine SL (1984) Long-term follow-up of central serous chorioretinopathy. Br J Ophthalmol 68:815–820

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Wang MS, Sander B, Larsen M (2002) Retinal atrophy in idiopathic central serous chorioretinopathy. Am J Ophthalmol 133:787–793

    Article  PubMed  Google Scholar 

  10. Ojima Y, Hangai M, Sasahara M, Gotoh N, Inoue R, Yasuno Y, Makita S, Yatagai T, Tsujikawa A, Yoshimura N (2007) Three-dimensional imaging of the foveal photoreceptor layer in central serous chorioretinopathy using high-speed optical coherence tomography. Ophthalmology 114:2197–2207

    Article  PubMed  Google Scholar 

  11. Matsumoto H, Sato T, Kishi S (2009) Outer nuclear layer thickness at the fovea determines visual outcomes in resolved central serous chorioretinopathy. Am J Ophthalmol 148:105–110

    Article  PubMed  Google Scholar 

  12. Ojima Y, Tsujikawa A, Yamashiro K, Ooto S, Tamura H, Yoshimura N (2010) Restoration of outer segments of foveal photoreceptors after resolution of central serous chorioretinopathy. Jpn J Ophthalmol 54:55–60

    Article  PubMed  Google Scholar 

  13. Ojima Y, Tsujikawa A, Hangai M, Nakanishi H, Inoue R, Sakamoto A, Yoshimura N (2008) Retinal sensitivity measured with the micro perimeter 1 after resolution of central serous chorioretinopathy. Am J Ophthalmol 146:77–84

    Article  PubMed  Google Scholar 

  14. Forooghian F, Stetson PF, Meyer SA, Chew EY, Wong WT, Cukras C, Meyerle CB, Ferris FL 3rd (2010) Relationship between photoreceptor outer segment length and visual acuity in diabetic macular edema. Retina 30:63–70

    Article  PubMed Central  PubMed  Google Scholar 

  15. Mohammad S, Gottlob I, Kumar A, Thomas M, Degg C, Sheth V, Proudlock FA (2011) The functional significance of foveal abnormalities in albinism measured using spectral-domain optical tomography. Ophthalmology 118:1645–1652

    Article  PubMed  Google Scholar 

  16. Chen CJ, Scholl HP, Birch DG, Iwata T, Miller NR, Goldberg MF (2012) Characterizing the phenotype and genotype of a family with occult macular dystrophy. Arch Ophthalmol 130:1554–1559

    Article  PubMed Central  PubMed  Google Scholar 

  17. Shiono A, Kogo J, Klose G, Takeda H, Ueno H, Tokuda N, Inoue J, Matsuzawa A, Kayama N, Ueno S, Takagi H (2013) Photoreceptor outer segment length: a prognostic factor for idiopathic epiretinal membrane surgery. Ophthalmology 120:788–794

    Article  PubMed  Google Scholar 

  18. Hasegawa T, Ueda T, Okamoto M, Ogata N (2014) Presence of foveal bulge in optical coherence tomographic images in eyes with macular edema associated with branch retinal vein occlusion. Am J Ophthalmol 157:390–396

    Article  PubMed  Google Scholar 

  19. Piccolino FC, de la Longrais RR, Ravera G, Eandi CM, Ventre L, Abdollahi A, Manea M (2005) The foveal photoreceptor layer and visual acuity loss in central serous chorioretinopathy. Am J Ophthalmol 139:87–99

    Article  PubMed  Google Scholar 

  20. Eandi CM, Chung JE, Cardillo-Piccolino F, Spaide RF (2005) Optical coherence tomography in unilateral resolved central serous chorioretinopathy. Retina 25:417–421

    Article  PubMed  Google Scholar 

  21. Fujita K, Shinoda K, Imamura Y, Matsumoto CS, Mizutani Y, Mizota A, Yuzawa M (2012) Correlation of integrity of cone outer segment tips line with retinal sensitivity after half-dose photodynamic therapy for chronic central serous chorioretinopathy. Am J Ophthalmol 154:579–585

    Article  PubMed  Google Scholar 

  22. Celesia GG, DeMarco PJ Jr (1994) Anatomy and physiology of the visual system. J Clin Neurophysiol 11:482–492

    Article  CAS  PubMed  Google Scholar 

  23. Pu GA, Masland RH (1984) Biochemical interruption of membrane phospholipid renewal in retinal photoreceptor cells. J Neurosci 4:1559–1576

    CAS  PubMed  Google Scholar 

  24. Hata M, Oishi A, Shimozono M, Mandai M, Nishida A, Kurimoto Y (2013) Early changes in foveal thickness in eyes with central serous chorioretinopathy. Retina 33:296–301

    Article  PubMed  Google Scholar 

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Conflicts of interest

The authors have no conflicts of interest.

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Authors and Affiliations

  1. Department of Ophthalmology, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan

    Taiji Hasegawa, Masahiro Okamoto, Naonori Masuda, Tetsuo Ueda & Nahoko Ogata

Authors
  1. Taiji Hasegawa
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  2. Masahiro Okamoto
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  3. Naonori Masuda
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  4. Tetsuo Ueda
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  5. Nahoko Ogata
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Corresponding author

Correspondence to Taiji Hasegawa.

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Hasegawa, T., Okamoto, M., Masuda, N. et al. Relationship between foveal microstructures and visual outcomes in eyes with resolved central serous chorioretinopathy. Graefes Arch Clin Exp Ophthalmol 253, 343–350 (2015). https://doi.org/10.1007/s00417-014-2695-2

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  • DOI: https://doi.org/10.1007/s00417-014-2695-2

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