Skip to main content

Advertisement

SpringerLink
Log in

Sectoral variations of iridocorneal angle width and iris volume in Chinese Singaporeans: a swept-source optical coherence tomography study

  • Glaucoma
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To assess variations in the iridocorneal angle width and iris volume in Chinese subjects using swept-source optical coherence tomography (SS-OCT).

Methods

Consecutive subjects, aged 40–80 years, with no previous ophthalmic problems were recruited from a population-based study of Chinese Singaporeans. All subjects underwent 360° SS-OCT (SS-1000 CASIA, Tomey Corporation, Nagoya, Japan) angle imaging and gonioscopy in one randomly selected eye in the dark. For each eye, 16 frames (11.25° apart) were selected for analysis from 128 cross-sectional images, and measurements of the trabecular iris space area 750 μm from the scleral spur (TISA750) and iris volume were made for each image. The measurements from four consecutive frames were further averaged as a sector of 45°. Sector-wise angle width and quadrant-wise iris volume were analyzed.

Results

Two hundred and twelve subjects (90 with closed-angles) were examined. The majority of the subjects were female (70.7 %) with mean age 61 (±8.9) years. The TISA750 (mm2) of superior [0.101 (0.09)], inferior [0.105 (0.09)], superior–nasal [0.111 (0.09)] and superior–temporal [0.117 (0.09)] sectors were smaller compared with other sectors (P < 0.05). The nasal iris volume (mm3) was the smallest compared with other quadrants for the entire cohort [nasal 8.18 (1.2) < inferior 9.13 (1.3) < temporal 9.16 (1.2) < superior 9.33 (1.3), P < 0.001], as well as for open- and closed-angle groups.

Conclusions

The irido-corneal angle was narrower in the superior, inferior, superior–nasal and superior–temporal sectors compared with other sectors. Iris volume in the nasal quadrant was the smallest compared with the other quadrants.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Foster PJ, Johnson GJ (2001) Glaucoma in China: how big is the problem? Br J Ophthalmol 85(11):1277–1282, Review

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  2. Friedman DS, He M (2008) Anterior chamber angle assessment techniques. Surv Ophthalmol 53(3):250–273

    Article  PubMed  Google Scholar 

  3. Pavlin CJ, Harasiewicz K, Sherar MD, Foster FS (1991) Clinical use of ultrasound biomicroscopy. Ophthalmology 98(3):287–295

    Article  CAS  PubMed  Google Scholar 

  4. Pavlin CJ, Harasiewicz K, Foster FS (1992) Ultrasound biomicroscopy of anterior segment structures in normal and glaucomatous eyes. Am J Ophthalmol 113(4):381–389

    CAS  PubMed  Google Scholar 

  5. Leung CK, Yung WH, Yiu CK et al (2006) Novel approach for anterior chamber angle analysis: anterior chamber angle detection with edge measurement and identification algorithm (ACADEMIA). Arch Ophthalmol 124(10):1395–1401

    Article  PubMed  Google Scholar 

  6. Dorairaj S, Liebmann JM, Ritch R (2007) Quantitative evaluation of anterior segment parameters in the era of imaging. Trans Am Ophthalmol Soc 105:99–108, discussion 108–10. Review

    PubMed Central  PubMed  Google Scholar 

  7. Lowe RF (1970) Aetiology of the anatomical basis for primary angle-closure glaucoma. Biometrical comparisons between normal eyes and eyes with primary angle-closure glaucoma. Br J Ophthalmol 54(3):161–169

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  8. Nongpiur ME, Sakata LM, Friedman DS et al (2010) Novel association of smaller anterior chamber width with angle closure in Singaporeans. Ophthalmology 117(10):1967–1973

    Article  PubMed  Google Scholar 

  9. Nongpiur ME, He M, Amerasinghe N et al (2011) Lens vault, thickness, and position in Chinese subjects with angle closure. Ophthalmology 118(3):474–479

    Article  PubMed  Google Scholar 

  10. Leung CK, Weinreb RN (2011) Anterior chamber angle imaging with optical coherence tomography. Eye (Lond) 25(3):261–267

    Article  Google Scholar 

  11. Baskaran M, Ho SW, Tun TA et al (2013) Assessment of circumferential angle-closure by the iris-trabecular contact index with swept-source optical coherence tomography. Ophthalmology 120(11):2226–2231

    Article  PubMed  Google Scholar 

  12. Liu S, Yu M, Ye C, Lam DS, Leung CK (2011) Anterior chamber angle imaging with swept-source optical coherence tomography: an investigation on variability of angle measurement. Invest Ophthalmol Vis Sci 52(12):8598–8603

    Article  PubMed  Google Scholar 

  13. Tun TA, Baskaran M, Zheng C et al (2013) Assessment of trabecular meshwork width using swept source optical coherence tomography. Graefes Arch Clin Exp Ophthalmol 251(6):1587–1592

    Article  PubMed  Google Scholar 

  14. Lavanya R, Jeganathan VS, Zheng Y et al (2009) Methodology of the Singapore Indian Chinese Cohort (SICC) Eye Study: quantifying ethnic variations in the epidemiology of eye diseases in Asians. Ophthalmic Epidemiol 16(6):325–336

    Article  PubMed  Google Scholar 

  15. SEAGIG guidelines (2008) Gonioscopy. Asia pacific glaucoma guidelines. Scientific Communications Int, Hong Kong, http://www.apglaucomasociety.org/toc/APGG2_fullversionNMview.pdf. Accessed July 3, 2013

    Google Scholar 

  16. Ho SW, Baskaran M, Zheng C et al (2013) Swept source optical coherence tomography measurement of the iris-trabecular contact (ITC) index: a new parameter for angle closure. Graefes Arch Clin Exp Ophthalmol 251(4):1205–1211

    Article  PubMed  Google Scholar 

  17. Mak H, Xu G, Leung CK (2013) Imaging the iris with swept-source optical coherence tomography: relationship between iris volume and primary angle closure. Ophthalmology 120(12):2517–2524

    Article  PubMed  Google Scholar 

  18. Conover WJ (1999) Practical nonparametric statistics, 3rd edn. John Wiley & Sons, New York

    Google Scholar 

  19. Radhakrishnan S, Goldsmith J, Huang D et al (2005) Comparison of optical coherence tomography and ultrasound biomicroscopy for detection of narrow anterior chamber angles. Arch Ophthalmol 123(8):1053–1059

    Article  PubMed  Google Scholar 

  20. Radhakrishnan S, Huang D, Smith SD (2005) Optical coherence tomography imaging of the anterior chamber angle. Ophthalmol Clin N Am 18(3):375–381, vi. Review

    Article  Google Scholar 

  21. Khor WB, Sakata LM, Friedman DS et al (2010) Evaluation of scanning protocols for imaging the anterior chamber angle with anterior segment-optical coherence tomography. J Glaucoma 19(6):365–368

    Article  PubMed  Google Scholar 

  22. He M, Foster PJ, Ge J et al (2006) Gonioscopy in adult Chinese: the Liwan Eye Study. Invest Ophthalmol Vis Sci 47(11):4772–4779

    Article  PubMed  Google Scholar 

  23. Kunimatsu S, Tomidokoro A, Mishima K et al (2005) Prevalence of appositional angle closure determined by ultrasonic biomicroscopy in eyes with shallow anterior chambers. Ophthalmology 112(3):407–412

    Article  PubMed  Google Scholar 

  24. Phillips CI (1956) Closed-angle glaucoma; significance of sectoral variations in angle depth. Br J Ophthalmol 40(3):136–143

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  25. Phillips CI (1956) Sectoral distribution of goniosynechiae. Br J Ophthalmol 40(3):129–135

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  26. Sakata LM, Lavanya R, Friedman DS et al (2008) Comparison of gonioscopy and anterior segment ocular coherence tomography in detecting angle closure in different quadrants of the anterior chamber angle. Ophthalmology 115(5):769–774

    Article  PubMed  Google Scholar 

  27. Sihota R, Dada T, Gupta R, Lakshminarayan P, Pandey RM (2005) Ultrasound biomicroscopy in the subtypes of primary angle closure glaucoma. J Glaucoma 14(5):387–391

    Article  PubMed  Google Scholar 

  28. Wang BS, Narayanaswamy A, Amerasinghe N et al (2011) Increased iris thickness and association with primary angle closure glaucoma. Br J Ophthalmol 95(1):46–50

    Article  PubMed  Google Scholar 

  29. Wang B, Sakata LM, Friedman DS et al (2010) Quantitative iris parameters and association with narrow angles. Ophthalmology 117(1):11–17

    Article  PubMed  Google Scholar 

Download references

Grant support

The study was supported by a Translational Clinical Research Partnership grant from the Biomedical Research Council (BMRC), Singapore (Grant No. 10/1/35/19/674) and National Medical Research Council.

Author information

Authors and Affiliations

  1. Singapore Eye Research Institute and Singapore National Eye Centre, 11 Third Hospital Avenue, Singapore, 168751, Singapore

    Tin A. Tun, Mani Baskaran, Shamira A. Perera, Anita S. Chan, Hla M. Htoon, Carol Y. Cheung & Tin Aung

  2. Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore

    Mani Baskaran, Carol Y. Cheung & Tin Aung

  3. Duke–NUS Graduate Medical School, National University of Singapore, Singapore, Singapore

    Mani Baskaran, Ching-Yu Cheng, Hla M. Htoon, Carol Y. Cheung & Tin Aung

  4. Department of Pathology, Singapore General Hospital, Singapore, Singapore

    Anita S. Chan

  5. Saw Swee Hock School of Public Health, National University of Singapore, Singapore, Singapore

    Ching-Yu Cheng

  6. Federal University of Parana, Curitiba, Brazil

    Lisandro M. Sakata

Authors
  1. Tin A. Tun
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Mani Baskaran
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shamira A. Perera
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Anita S. Chan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Ching-Yu Cheng
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Hla M. Htoon
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Lisandro M. Sakata
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Carol Y. Cheung
    View author publications

    You can also search for this author in PubMed Google Scholar

  9. Tin Aung
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tin Aung.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Tun, T.A., Baskaran, M., Perera, S.A. et al. Sectoral variations of iridocorneal angle width and iris volume in Chinese Singaporeans: a swept-source optical coherence tomography study. Graefes Arch Clin Exp Ophthalmol 252, 1127–1132 (2014). https://doi.org/10.1007/s00417-014-2636-0

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-014-2636-0

Keywords

Search

Navigation