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Changes in fundus autofluorescence in polypoidal choroidal vasculopathy during 3 years of follow-up

  • Retinal Disorders
  • Published:
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Abstract

Purpose

To investigate changes in fundus autofluorescence (FAF) during 3 years of follow-up in patients with polypoidal choroidal vasculopathy (PCV).

Design

Retrospective study.

Methods

We retrospectively reviewed the charts of 48 eyes of 47 patients (35 men, 12 women; mean age, 69.9 ± 7.1 years) with treatment-naïve PCV for whom FAF and indocyanine green angiography (ICGA) images were available at baseline and at 3 years ± 3 months follow-up examination. The main outcome measures were the FAF changes during 3 years of follow-up, and the correlation between them and polypoidal lesions and branching vascular networks on ICGA.

Results

The FAF of the polypoidal lesions showed three patterns at baseline and changes during 3 years of follow-up: confluent hypoautofluorescence surrounded by a hyperautofluorescent ring (86.1 % → 51.4 %), confluent hypoautofluorescence without a ring (8.3 % → 43.0 %), and no marked changes (5.6 % → 5.6 %). The FAF in 96.2 % of resolved polypoidal lesions persisted on images with abnormal FAF during the 3 years of follow-up. The granular hypoautofluorescence at the branching vascular networks at baseline became partially confluent hypoautofluorescence in 41 eyes (85.4 %). The mean area with confluent hypoautofluorescence that corresponded to the branching vascular network lesions increased significantly (P < 0.001) from 1.75 mm2 to 5.10 mm2 after 3 years of follow-up.

Conclusion

The FAF changes in PCV during the 3 years of follow-up can indicate that FAF imaging is a useful and clinically beneficial tool for noninvasively evaluating the PCV lesions and disorders of the upper retinal pigment epithelium.

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Acknowledgments

All authors have completed and submitted the ICMJE Form for Disclosure of Potential Conflicts of Interest, and none were reported. Involved in design (M.S., F.G.), conduct (M.S., F.G.), data collection (M.S., F.G., C.U., M.S.), analysis and interpretation of the data (M.S., F.G.), and preparation and review of the manuscript (M.S., F.G., K.N.). The institutional review board of Osaka University Hospital, Osaka, Japan, approved this retrospective study. The data collection complied with Japanese law. The study was conducted in accordance with the provisions of the Declaration of Helsinki.

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Authors and Affiliations

  1. Department of Ophthalmology, Osaka University Medical School, Osaka, Japan

    Mihoko Suzuki, Miki Sawa, Chikako Ueno & Kohji Nishida

  2. Department of Ophthalmology, Sumitomo Hospital, Nakanoshima, Kita-ku, Osaka, 530-0005, Japan

    Fumi Gomi

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  1. Mihoko Suzuki
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  2. Fumi Gomi
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  3. Miki Sawa
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  4. Chikako Ueno
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  5. Kohji Nishida
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Corresponding author

Correspondence to Fumi Gomi.

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Suzuki, M., Gomi, F., Sawa, M. et al. Changes in fundus autofluorescence in polypoidal choroidal vasculopathy during 3 years of follow-up. Graefes Arch Clin Exp Ophthalmol 251, 2331–2337 (2013). https://doi.org/10.1007/s00417-013-2336-1

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  • DOI: https://doi.org/10.1007/s00417-013-2336-1

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