References
Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343–353
Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, Fernandez-Delgado J, Nistal M, Alio JL (2008) Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells 26:570–579
Bunnell BA, Flaat M, Gaqliardi C, Patel B, Ripoll C (2008) Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45:115–120
Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E (2009) Adipocytes as immune cells: differential expression of TWEAK, BAFF and APRIL and their receptors (Fn14, BAFF-R, TACI and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol 183:5948–5956
Daher SR, Johnstone BH, Phinney DG, March KL (2008) Adipose stromal/stem cells: basic and translational advances: the IFATS collection. Stem Cells 26:2664–2665
Uccelli A, Moretta L, Pistoia V (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8:726–736
Phinney DG, Prockop DJ (2007) Mesenchymal stem/multi-potent stromal cells (MSCs): the state of transdifferentiation and modes of tissue repair — current views. Stem Cells 25:2896–2902
Körbling M, Estrov Z (2003) Adult stem cells for tissue repair — a new therapeutic concept? N Engl J Med 349:570–582
Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, Kon E, Marcacci M (2001) Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344:385–386
Meirelles Lda S, Fontes AM, Covas DT, Caplan AI (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20:419–427
Acknowledgements
We thank the heads of the Ophthalmology and Experimental Endocrinology departments (University of Crete, School of Medicine, Heraklion, Greece), Professors Ioannis G Pallikaris and Elias Castanas, for their constant support and fruitful discussions, which stimulated the current study.
Author information
Authors and Affiliations
Corresponding author
Additional information
George I. Agorogiannis and Vassilia-Ismini Alexaki have contributed equally to this manuscript.
Rights and permissions
About this article
Cite this article
Agorogiannis, G.I., Alexaki, VI., Castana, O. et al. Topical application of autologous adipose-derived mesenchymal stem cells (MSCs) for persistent sterile corneal epithelial defect. Graefes Arch Clin Exp Ophthalmol 250, 455–457 (2012). https://doi.org/10.1007/s00417-011-1841-3
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00417-011-1841-3