Skip to main content
Log in

Topical application of autologous adipose-derived mesenchymal stem cells (MSCs) for persistent sterile corneal epithelial defect

  • Case Report
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2

References

  1. Centeno CJ, Busse D, Kisiday J, Keohan C, Freeman M, Karli D (2008) Increased knee cartilage volume in degenerative joint disease using percutaneously implanted, autologous mesenchymal stem cells. Pain Physician 11:343–353

    PubMed  Google Scholar 

  2. Arnalich-Montiel F, Pastor S, Blazquez-Martinez A, Fernandez-Delgado J, Nistal M, Alio JL (2008) Adipose-derived stem cells are a source for cell therapy of the corneal stroma. Stem Cells 26:570–579

    Article  PubMed  CAS  Google Scholar 

  3. Bunnell BA, Flaat M, Gaqliardi C, Patel B, Ripoll C (2008) Adipose-derived stem cells: isolation, expansion and differentiation. Methods 45:115–120

    Article  PubMed  CAS  Google Scholar 

  4. Alexaki VI, Notas G, Pelekanou V, Kampa M, Valkanou M, Theodoropoulos P, Stathopoulos EN, Tsapis A, Castanas E (2009) Adipocytes as immune cells: differential expression of TWEAK, BAFF and APRIL and their receptors (Fn14, BAFF-R, TACI and BCMA) at different stages of normal and pathological adipose tissue development. J Immunol 183:5948–5956

    Article  PubMed  CAS  Google Scholar 

  5. Daher SR, Johnstone BH, Phinney DG, March KL (2008) Adipose stromal/stem cells: basic and translational advances: the IFATS collection. Stem Cells 26:2664–2665

    Article  PubMed  Google Scholar 

  6. Uccelli A, Moretta L, Pistoia V (2008) Mesenchymal stem cells in health and disease. Nat Rev Immunol 8:726–736

    Article  PubMed  CAS  Google Scholar 

  7. Phinney DG, Prockop DJ (2007) Mesenchymal stem/multi-potent stromal cells (MSCs): the state of transdifferentiation and modes of tissue repair — current views. Stem Cells 25:2896–2902

    Article  PubMed  Google Scholar 

  8. Körbling M, Estrov Z (2003) Adult stem cells for tissue repair — a new therapeutic concept? N Engl J Med 349:570–582

    Article  PubMed  Google Scholar 

  9. Quarto R, Mastrogiacomo M, Cancedda R, Kutepov SM, Mukhachev V, Lavroukov A, Kon E, Marcacci M (2001) Repair of large bone defects with the use of autologous bone marrow stromal cells. N Engl J Med 344:385–386

    Article  PubMed  CAS  Google Scholar 

  10. Meirelles Lda S, Fontes AM, Covas DT, Caplan AI (2009) Mechanisms involved in the therapeutic properties of mesenchymal stem cells. Cytokine Growth Factor Rev 20:419–427

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank the heads of the Ophthalmology and Experimental Endocrinology departments (University of Crete, School of Medicine, Heraklion, Greece), Professors Ioannis G Pallikaris and Elias Castanas, for their constant support and fruitful discussions, which stimulated the current study.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to George D. Kymionis.

Additional information

George I. Agorogiannis and Vassilia-Ismini Alexaki have contributed equally to this manuscript.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Agorogiannis, G.I., Alexaki, VI., Castana, O. et al. Topical application of autologous adipose-derived mesenchymal stem cells (MSCs) for persistent sterile corneal epithelial defect. Graefes Arch Clin Exp Ophthalmol 250, 455–457 (2012). https://doi.org/10.1007/s00417-011-1841-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-011-1841-3

Keywords

Navigation