Abstract
Purpose
To evaluate long-term corneal endothelial cell changes of intraocular lens (IOL) reposition and exchange in children.
Setting
State key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, 510060, China
Methods
In this retrospective study, all IOL reposition and exchange procedures performed in patients under 14 years old between January 1999 and April 2009 were included. Follow-up outcomes included corneal endothelial cell density, hexagonality, coefficient of variance, average cell size.
Results
IOL reposition procedures in 12 eyes (12 cases) (reposition group, RPG), and IOL exchanges in eight eyes (eight cases) (exchange group, EXG) were performed because of IOL pupillary capture or IOL dislocation. Median of follow-up was 44.5 months in RPG and 66.2 months in EXG. The density of corneal endothelial cells in RPG (2,053 ± 493/mm2) and EXG (2,100 ± 758/mm2) was significantly decreased in comparison to the control eyes (3,116 ± 335/mm2). Hexagonality of corneal endothelial cells and coefficient of variance showed no difference among the control group, RPG and EXG (P > 0.05).
Conclusions
The density of corneal endothelial cells was conspicuously decreased after IOL reposition or exchange procedures in childhood cases. Longer follow-up must be conducted in these cases.
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References
Obstbaum SA, To K (1989) Posterior chamber intraocular lens dislocations and malpositions. Aust N Z J Ophthalmol 17:265–271
Nagamoto S, Kohzuka T, Nagamoto T (1998) Pupillary block after pupillary capture of an AcrySof intraocular lens. J Cataract Refract Surg 24:1271–1274
Khokhar S, Sethi HS, Sony P, Sudan R, Soni A (2002) Pseudophakic pupillary block caused by pupillary capture after phacoemulsification and in-the-bag AcrySof lens implantation1. J Cataract Refract Surg 28:1291–1292
Sinskey RM, Amin P, Stoppel JO (1993) Indications for and results of a large series of intraocular lens exchanges. J Cataract Refract Surg 19:68–71
Mamalis N, Crandall AS, Pulsipher MW, Follett S, Monson MC (1991) Intraocular lens explantation and exchange. A review of lens styles, clinical indications, clinical results, and visual outcome. J Cataract Refract Surg 17:811–818
Marques FF, Marques D, Osher RH, Freitas LL (2007) Longitudinal study of intraocular lens exchange. J Cataract Refract Surg 33:254–257
Smith SG, Lindstrom RL (1985) Malpositioned posterior chamber lenses: etiology, prevention, and management. J Am Intraocular Implant Soc 11:584–591
Jakobsson G, Zetterberg M, Lundström M, Stenevi U, Grenmark R, Sundelin K (2010) Late dislocation of in-the-bag and out-of-the bag intraocular lenses: Ocular and surgical characteristics and time to lens repositioning. J Cataract Refract Surg 36:1637–1644
Lavin M, Jagger J (1986) Pathogenesis of pupillary capture after posterior chamber intraocular lens implantation. Br J Ophthalmol 70:886–889
Bartholomew RS (1997) Incidence, causes, and neodymium:YAG laser treatment of pupillary capture. J Cataract Refract Surg 23:1404–1408
Lindstrom RL, Herman WK (1983) Pupil capture: prevention and management. J Am Intraocul Implant Soc 9:201–204
Mello MO Jr, Scott IU, Smiddy WE (2000) Surgical management and outcomes of dislocated intraocular lenses. Ophthalmology 107:62–67
Asadi R, Kheirkhah A (2008) Long-term results of scleral fixation of posterior chamber intraocular lenses in children. Ophthalmology 115:67–72
Sharma N, Pushker N, Dada T, Vajpayee RB, Dada VK (1999) Complications of pediatric cataract surgery and intraocular lens implantation. J Cataract Refract Surg 25:1585–1588
Vasavada V, Vasavada VA, Hoffman RO, Spencer TS, Kumar RV, Crandall AS (2008) Intraoperative performance and postoperative outcomes of endocapsular ring implantation in pediatric eyes. J Cataract Refract Surg 34:1499–1508
Astle WF, Alewenah O, Ingram AD, Paszuk A (2009) Surgical outcomes of primary foldable intraocular lens implantation in children: Understanding posterior opacification and the absence of glaucoma. J Cataract Refract Surg 35:1216–1222
Framme C, Hoerauf H, Roider J, Laqua H (1998) Delayed intraocular lens dislocation after neodymium: YAG capsulotomy. J Cataract Refract Surg 24:1541–1543
Lin AA, Buckley EG (2010) Update on pediatric cataract surgery and intraocular lens implantation. Curr Opin Ophthalmol 21:55–59
Mustonen RK, McDonald MB, Srivannaboon S, Tan AL, Doubrava MW, Kim CK (1998) Normal human corneal cell populations evaluated by in vivo scanning slit confocal microscopy. Cornea 17:485–492
Moller-Pedersen T (1997) A comparative study of human corneal keratocyte and endothelial cell density during aging. Cornea 16:333–338
Bourne WM, Nelson LR, Hodge DO (1997) Central corneal endothelial cell changes over a ten-year period. Invest Ophthalmol Vis Sci 38:779–782
Nucci P, Brancato R, Mets MB, Shevell SK (1990) Normal endothelial cell density range in childhood. Arch Ophthalmol 108:247–248
Muller A, Craig JP, Grupcheva CN, McGhee CN (2004) The effects of corneal parameters on the assessment of endothelial cell density in the elderly eye. Br J Ophthalmol 88:325–330
Abib FC, Barreto J (2001) Behavior of corneal endothelial density over a lifetime. J Cataract Refract Surg 27:1574–1578
Storr-Paulsen A, Norregaard JC, Ahmed S, Storr-Paulsen T, Pedersen TH (2008) Endothelial cell damage after cataract surgery: divide-and-conquer versus phaco-chop technique. J Cataract Refract Surg 34:996–1000
Basti S, Aasuri MK, Reddy S, Reddy S, Rao GN (1998) Prospective evaluation of corneal endothelial cell loss after pediatric cataract surgery. J Cataract Refract Surg 24:1469–1473
Schultz RO, Glasser DB, Matsuda M, Yee RW, Edelhauser HF (1986) Response of the corneal endothelium to cataract surgery. Arch Ophthalmol 104:1164–1169
Kraff MC, Sanders DR, Lieberman HL (1982) Monitoring for continuing endothelial cell loss with cataract extraction and intraocular lens implantation. Ophthalmology 89:30–34
Miyake K, Mibu H, Horiguchi M, Shirasawa E (1990) Inflammatory mediators in postoperative aphakic and pseudophakic baboon eyes. Arch Ophthalmol 108:1764–1767
Rowland FN, Donovan MJ, Lindsay M, Weiss WI, O'Rourke J, Kreutzer DL (1983) Demonstration of inflammatory mediator-induced inflammation and endothelial cell damage in the anterior segment of the eye. Am J Pathol 110:1–12
Odenthal MT, Sminia ML, Prick LJ, Gortzak-Moorstein N, Völker-Dieben HJ (2006) Long-term follow-up of the corneal endothelium after artisan lens implantation for unilateral traumatic and unilateral congenital cataract in children: two case series. Cornea 25:1173–1177
Gagnon MM, Boisjoly HM, Brunette I, Charest M, Amyot M (1997) Corneal endothelial cell density in glaucoma. Cornea 16:314–318
Higa A, Sakai H, Sawaguchi S, Iwase A, Tomidokoro A, Amano S, Araie M (2010) Corneal endothelial cell density and associated factors in a population-based study in Japan: the Kumejima study. Am J Ophthalmol 149:794–799
Langston RH (1982) Prevention and management of corneal decompensation. Int Ophthalmol Clin 22:189–201
Amann J, Holley GP, Lee SBM, Edelhauser HF (2003) Increased endothelial cell density in the paracentral and peripheral regions of the human cornea. Am J Ophthalmol 135:584–590
Bednarz J, Rodokanaki-von Schrenck A, Engelmann K (1998) Different characteristics of endothelial cells from central and peripheral human cornea in primary culture and after subculture. In Vitro Cell Dev Biol Anim 34:149–153
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Grant of Chinese National Natural Science Foundation 81070719 and Key Programs for Clinical Subjects of Chinese Ministry of Health 20100439.
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Wang, Y., Wu, M., Zhu, L. et al. Long-term corneal endothelial cell changes in pediatric intraocular lens reposition and exchange cases. Graefes Arch Clin Exp Ophthalmol 250, 547–555 (2012). https://doi.org/10.1007/s00417-011-1837-z
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DOI: https://doi.org/10.1007/s00417-011-1837-z