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Clinical characteristics of polypoidal choroidal vasculopathy in Chinese patients

  • Retinal Disorders
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To describe the clinical characteristics of polypoidal choroidal vasculopathy (PCV) in a large number of Chinese patients.

Methods

This study enrolled 204 consecutive patients (246 eyes) in our department who were diagnosed as having polypoidal choroidal vasculopathy PCV. Patients underwent ophthalmologic examinations including best-corrected visual acuity (BCVA) testing, ophthalmoscopy, fundus photography, fluorescein angiography, indocyanine green angiography, and optic coherence tomography.

Results

Mean patient age was 66.1 years and 60.3% were men. Of the cases, 79.4% were unilateral and 51.2% of BCVA was less than 35 letters. In 171 eyes (69.5%), polypoidal lesions were located in the macula area. Among them, polypoidal lesions were located in the foveal area in 29 eyes (11.8%), in the parafoveal area in 50 eyes (20.3%), and in the extrafoveal area in 88 eyes (35.8%), in both the foveal and parafoveal area in three eyes (1.2%), and in both the parafoveal and extrafoveal area in one eye (0.4%). In 37 eyes (15.0%), PCV lesions were under the temporal retinal vascular arcade; in 11 eyes (4.5%), PCV lesions were found peripapillary. PCV lesion formation was single in 88 eyes (35.8%), cluster in 145 eyes (59.0%), string in two eyes (0.8%), and branch in two eyes (0.8%). In nine eyes (3.6%), the formation of PCV lesions showed both single and cluster shape in the same eye. There were 54.5% with drusen, 44.7% with serous PED, 20.7% with hemorrhagic PED, and 39.0% with neuroretinal detachment.

Conclusions

The majority of Chinese PCV patients were male, unilateral, and showed macular polyps. Drusen, serous PED, hemorrhagic PED, and neuroretinal detachment on OCT were commonly seen.

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Acknowledgements

This study was supported by the Major State Basic Research Development Program of China (No:2005CB724307), the National Natural Science Foundation of China (No:30901639), the Beijing Novel Program (No:2009B04), Special Funds for Central Health research projects (No.B2009B041; China:MWZ) and the Epidemiological Survey and Consultation Network Construction of Polypoidal Choroidal Vasculopathy in the Beijing Region.

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Authors and Affiliations

  1. Department of Ophthalmology, People’s Hospital, Peking University, 11 Xizhimen South Street, Xicheng District, 100044, Beijing, China

    Jing Hou, Yong Tao, Xiao-xin Li & Ming-wei Zhao

  2. Key Laboratory of Vision Loss and Restoration, Ministry of Education, Beijing, China

    Jing Hou, Yong Tao, Xiao-xin Li & Ming-wei Zhao

Authors
  1. Jing Hou
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  2. Yong Tao
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  3. Xiao-xin Li
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  4. Ming-wei Zhao
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Corresponding author

Correspondence to Xiao-xin Li.

Additional information

Jing Hou and Yong Tao contributed equally to the work.

Proprietary interest: None

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Hou, J., Tao, Y., Li, Xx. et al. Clinical characteristics of polypoidal choroidal vasculopathy in Chinese patients. Graefes Arch Clin Exp Ophthalmol 249, 975–979 (2011). https://doi.org/10.1007/s00417-010-1575-7

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  • DOI: https://doi.org/10.1007/s00417-010-1575-7

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