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Fundus autofluorescence and spectral-domain optical coherence tomography findings of leopard spots in nanophthalmic uveal effusion syndrome

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Abstract

Purpose

To describe fundus autofluorescence (FAF) imaging and spectral domain optical coherence tomography (SD-OCT) findings of leopard spots in nanophthalmic uveal effusion syndrome.

Methods

A 34-year-old man with retinal detachment associated with nanophthalmic uveal effusion syndrome in the right eye underwent sclerotomy three times. After the final surgery, the subretinal fluid resolved gradually. Then, SD-OCT examination, FAF photography, fluorescein angiography (FA), and indocyanine green angiography (ICGA) were performed simultaneously with the spectralis Heidelberg retina angiograph + OCT system.

Results

SD-OCT revealed focal thickening of the retinal pigment epithelium (RPE) layer at the same locations as leopard spots, which appeared hypofluorescent on FA and ICGA. These spots showed hyperautofluorescence on FAF imaging. Six months later, focal thickening of the RPE layer became smaller on OCT and hyperautofluorescence was attenuated on FAF imaging.

Conclusions

Simultaneous imaging of the fundus with multiple modalities including OCT, FAF, FA, and ICGA indicates that leopard spots in the fundus of uveal effusion syndrome may show hyperautofluorescence and correspond to focal thickening of the RPE layer by SD-OCT. This imaging method may help elucidate the pathology of various fundus lesions in vivo.

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Authors and Affiliations

  1. Department of Ophthalmology, Kanazawa University Graduate School of Medical Science, 13-1 Takara-machi, Kanazawa, Ishikawa Prefecture, 920-8641, Japan

    Tetsuhiko Okuda, Tomomi Higashide, Yuka Wakabayashi, Akira Nishimura & Kazuhisa Sugiyama

Authors
  1. Tetsuhiko Okuda
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  2. Tomomi Higashide
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  3. Yuka Wakabayashi
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  4. Akira Nishimura
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  5. Kazuhisa Sugiyama
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Corresponding author

Correspondence to Tetsuhiko Okuda.

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No author of this manuscript had a proprietary or financial interest in it.

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Okuda, T., Higashide, T., Wakabayashi, Y. et al. Fundus autofluorescence and spectral-domain optical coherence tomography findings of leopard spots in nanophthalmic uveal effusion syndrome. Graefes Arch Clin Exp Ophthalmol 248, 1199–1202 (2010). https://doi.org/10.1007/s00417-010-1352-7

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  • DOI: https://doi.org/10.1007/s00417-010-1352-7

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