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Effect of anterior chamber air bubble on prevention of experimental Staphylococcus epidermidis endophthalmitis

  • Inflammatory Disorders
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Abstract

Background

Bacterial endophthalmitis is a serious complication of penetrating ocular trauma and cataract surgery. The purpose of this study is to assess the ability of an anterior chamber air bubble to prevent experimental Staphylococcus epidermidis endophthalmitis.

Methods

The anterior chamber was opened with a clear corneal incision to drain the aqueous humor in one eye of 24 rabbits. S. epidermidis was injected into the anterior chamber. The infected rabbits were randomly divided into two groups. Animals in group 1 (n = 12) received an air bubble to reconstruct the anterior chamber, and animals in Group 2 (n = 12) received Balanced Salt Solution (BSS) for reconstruction. Clinical examination in each group was performed 2, 3 and 7 days after inoculation of the bacteria. Clinical examination scores were recorded. All eyes were enucleated for histophatological examination.

Results

Clinical endophthalmitis was seen in 7/12 (58.3%) in group 2, but in only 1/12 (8.3%) in group 1 (p = 0.027). Mean clinical scores of groups 1and 2 on the 3rd day were 2.6 ± 1.4 and 7.2 ± 1.7 respectively. (p < 0.001). The mean clinical scores of groups 1and 2 on the 7th day were 2.3 ± 1.2 and 6.8 ± 1.5 respectively (p < 0.001). Histopathological examination confirmed clinical findings.

Conclusion

An air bubble in the anterior chamber may have protective effects against the development of experimental S. epidermidis endophthalmitis.

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Acknowledgment

Appreciation is expressed to the staff of the Animal Laboratory of the Shiraz University of Medical Sciences for their generous assistance, and to K. Shashok (AuthorAID in the Eastern Mediterranean) for improving the use of English in the manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, Shiraz University of Medical Sciences, Poostchi Ophthalmology Research Center, Shiraz, 71935, Iran

    Morteza Mehdizadeh, Feisal Rahat, Mohammad Reza Khalili & Farzin Ahmadi

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  1. Morteza Mehdizadeh
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  2. Feisal Rahat
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  3. Mohammad Reza Khalili
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  4. Farzin Ahmadi
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Correspondence to Morteza Mehdizadeh.

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No authors have any financial/conflicting interests to disclose. The authors alone are responsible for the content and writing of the paper.

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Mehdizadeh, M., Rahat, F., Khalili, M.R. et al. Effect of anterior chamber air bubble on prevention of experimental Staphylococcus epidermidis endophthalmitis. Graefes Arch Clin Exp Ophthalmol 248, 277–281 (2010). https://doi.org/10.1007/s00417-009-1173-8

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  • DOI: https://doi.org/10.1007/s00417-009-1173-8

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