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Bevacizumab in the treatment of idiopathic macular telangiectasia

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Abstract

Background

To describe functional and morphological long-term follow-up results in patients with idiopathic macular telangiectasia (IMT) treated with intravitreal bevacizumab.

Methods

Retrospective case series of three consecutive male patients with IMT who were treated with intravitreal bevacizumab injections. Best corrected visual acuity (BCVA) as well as fluorescein angiography (FA) and optical coherence tomography (OCT) were monitored over the period of up to 12 months.

Results

Single intravitreal bevacizumab injection resulted in a marked increase in BCVA from 20/50 to 20/20 in the patient with type 1 (aneurysmal) IMT during the first 4 weeks. Late-phase leakage on FA and cystoid macular oedema on OCT decreased significantly. This was sustained over the whole follow-up period of 12 months. In contrast, in the two patients with type 2 (perifoveal) IMT, leakage on FA decreased likewise, but this was not accompanied by an increase in BCVA despite triple injections. Small cystic changes seen on OCT remained unchanged.

Conclusion

Patients with type 1 IMT with pronounced macular oedema on OCT may benefit from intravitreal bevacizumab injections, showing functional as well as morphological improvement, while patients with type 2 IMT with minimal cystic changes on OCT do not show functional improvement despite repeated injections.

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References

  1. Gass JDM (1968) A fluorescein angiographic study of macular dysfunction secondary to retinal vascular disease. V. Retinal telangiectasis. Arch Ophthalmol 80:592–605

    PubMed  CAS  Google Scholar 

  2. Gass JDM, Blodi BA (1993) Idiopathic juxtafoveolar retinal telangiectasis: update of classification and follow-up study. Ophthalmology 100:1536–1546

    PubMed  CAS  Google Scholar 

  3. Yannuzzi LA, Bardal AMC, Freund KB, Chen KJ, Eandi CM, Blodi B (2006) Idiopathic macular telangiectasia. Arch Ophthalmol 124(4):450–460

    Article  PubMed  Google Scholar 

  4. Paunescu LA, Ko TH, Duker JS, Chan A, Drexler W, Schuman JS, Fujimoto JG (2006) Idiopathic juxtafoveal retinal telangiectasis: new findings by ultrahigh-resolution optical coherence tomography. Ophthalmology 113(1):48–57

    Article  PubMed  Google Scholar 

  5. Surguch V, Gamulescu MA, Gabel VP (2007) Optical coherence tomography findings in idiopathic juxtafoveal retinal telangiectasis. Graefes Arch Clin Exp Ophthalmol 245(6):783–788

    Article  PubMed  Google Scholar 

  6. Potter MJ, Szabo SM, Chan EY, Morris AH (2002) Photodynamic therapy of a subretinal neovascular membrane in type 2A idiopathic juxtafoveolar retinal telangiectasis. Am J Ophthalmol 133(1):149–151

    Article  PubMed  Google Scholar 

  7. Lynch SS, Cheng CM (2007) Bevacizumab for neovascular ocular diseases. Ann Pharmacother 41(4):614–625

    Article  PubMed  CAS  Google Scholar 

  8. Chew EY (2006) Parafoveal telangiectasis. In: Ryan SJ, Hinton DR, Schachat AP, Wilkinson CP (eds) Retina 4th ed. Vol. 2. Mosby, St. Louis, pp 1409–1415

    Google Scholar 

  9. Park DW, Schatz H, McDonald HR, Johnson RN (1997) Grid laser photocoagulation for macular edema in bilateral juxtafoveal telangiectasis. Ophthalmology 104(11):1838–1846

    PubMed  CAS  Google Scholar 

  10. Alldredge CD, Garretson BR (2003) Intravitreal triamcinolone for the treatment of idiopathic juxtafoveal telangiectasis. Retina 23(1):113–116

    Article  PubMed  Google Scholar 

  11. Li KK, Goh TY, Parsons H, Chan WM, Lam DS (2005) Use of intravitreal triamcinolone acetonide injection in unilateral idiopathic juxtafoveal telangiectasis. Clin Experiment Ophthalmol 33(5):542–544

    Article  PubMed  Google Scholar 

  12. Moon SJ, Berger AS, Tolentino MJ, Misch DM (2007) Intravitreal bevacizumab for macular edema from idiopathic juxtafoveal retinal telangiectasis. Ophthalmic Surg Lasers Imaging 38(2):164–166

    PubMed  Google Scholar 

  13. Schulze S, Mennel S (2007) Behandlung idiopathischer juxtafoveolärer retinaler Teleangiektasien mit Bevacizumab (Avastin). Klin Monatsbl Augenheilkd 224:787–790

    Article  PubMed  CAS  Google Scholar 

  14. Charbel Issa P, Holz FG, Scholl HPN (2007) Findings in fluorescein angiography and optical coherence tomography after intravitreal bevacizumab in type 2 idiopathic macular telangiectasia. Ophthalmology 114:1736–1742

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. University Eye Clinic, Franz-Joseph-Strauss Allee 11, 93053, Regensburg, Germany

    Maria-Andreea Gamulescu, Andreas Walter, Helmut Sachs & Horst Helbig

Authors
  1. Maria-Andreea Gamulescu
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  2. Andreas Walter
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  3. Helmut Sachs
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  4. Horst Helbig
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Corresponding author

Correspondence to Maria-Andreea Gamulescu.

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All authors have full control of all primary data, and agree to allow Graefe's Archive for Clinical and Experimental Ophthalmology to review their data on request.

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Gamulescu, MA., Walter, A., Sachs, H. et al. Bevacizumab in the treatment of idiopathic macular telangiectasia. Graefes Arch Clin Exp Ophthalmol 246, 1189–1193 (2008). https://doi.org/10.1007/s00417-008-0795-6

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  • DOI: https://doi.org/10.1007/s00417-008-0795-6

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