Skip to main content

Advertisement

SpringerLink
Log in

The combined use of perfluorohexyloctane (F6H8) and silicone oil as an intraocular tamponade in the treatment of severe retinal detachment

  • Clinical Investigation
  • Published:
Graefe's Archive for Clinical and Experimental Ophthalmology Aims and scope Submit manuscript

Abstract

Background

The purpose of this study was to investigate the combined use of perfluorohexyloctane (F6H8) and 1,000-centistoke silicone oil as a long-term intraocular tamponade in the treatment of complicated retinal detachment.

Methods

Sixty consecutive eyes affected by complicated retinal detachment with (1) retinal breaks of the lower two quadrants and severe proliferative vitreoretinopathy, (2) inferior giant retinal tear, (3) penetrating trauma or (4) choroidal detachment underwent pars plana vitrectomy using a combined internal tamponade of F6H8 and silicone oil. The double filling (DF) was removed after 40–50 days. The anatomical outcome and the complications due to the DF are reported.

Results

Retinal reattachment was achieved in all but one patient. Thirty-eight (63%) eyes needed further surgery with silicone oil tamponade. Silicone oil was successfully removed in 22 eyes. Sixteen (27%) eyes had retained silicone oil at the last follow-up examination. One eye showed persistent retinal detachment despite further surgery. Main complications of the DF were recurrent retinal detachment of the upper retina in six (10%) eyes and membrane formation in 25 (42%) eyes.

Conclusions

A combined internal tamponade of F6H8 and silicone oil may be a useful tool in the treatment of complicated retinal detachment involving the lower quadrants of the retina.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

References

  1. Asaria RH, Kon CH, Bunce C, Charteris DG, Wong D, Khaw PT, Aylward GW (2001) Adjuvant 5-fluorouracil and heparin prevents proliferative vitreoretinopathy: results from a randomized, double-blind controlled clinical trial. Ophthalmology 108:1179–1183

    Article  PubMed  CAS  Google Scholar 

  2. Chang S, Zimmermann NJ, Iwamoto T, Ortiz R, Faris D (1987) Experimental vitreous replacement with perfluorotributylamine. Am J Ophthalmol 103:29–37

    PubMed  CAS  Google Scholar 

  3. Chang S, Sparrow JR, Iwamoto T, Gershbein A, Ross R, Ortiz R (1991) Experimental studies of tolerance to intravitreal perfluoro-n-octane liquid. Retina 11:367–374

    PubMed  CAS  Google Scholar 

  4. Cox MS, Trese MT, Murphy PL (1986) Silicone oil for advanced proliferative vitreoretinopathy. Ophthalmol 93:646–650

    CAS  Google Scholar 

  5. De Molfetta V, Bottoni F, Arpa P, Vinciguerra P, Zenoni S (1992) The effect of simultaneous internal tamponade on fluid compartimentalization and its relationship to cell proliferation. Retina 12:S40–S45

    Article  PubMed  Google Scholar 

  6. Eckart C, Nicolai U, Winter M, Knop E (1991) Experimental intraocular tolerance to liquid perfluorooctane and perfluoropolyether. Retina 11:375–384

    Article  Google Scholar 

  7. Fleury J, Bonnet M (1992) Prognostic value of new retinal tears associated with the development of postoperative proliferative vitreoretinopathy. Graefes Arch Clin Exp Ophthalmol 230:459–462

    Article  PubMed  CAS  Google Scholar 

  8. Herbert E, Stappler T, Wetterqvist C, Williams R, Wong D (2004) Tamponade properties of double-filling with perfluorohexyloctane and silicone oil in a model eye chamber. Graefes Arch Clin Exp Ophthalmol 242:692–696

    Google Scholar 

  9. Hiscott P, Magee RM, Colthurst M, Lois N, Wong D (2001) Clinicopathological correlation of epiretinal membranes and posterior lens opacification following perfluorohexyloctane tamponade. Br J Ophthalmol 85:179–183

    Article  PubMed  CAS  Google Scholar 

  10. Jonas JB, Knorr HLJ, Rank RM, Budde WM (2001) Retinal detachment after removal of intraocular silicone oil tamponade. Br J Ophthalmol 85:1203–1207

    Article  PubMed  CAS  Google Scholar 

  11. Kirchhof B, Wong D, Van Meurs J, Hilgers RD, Macek M, Lois N, Schrage NF (2002) Use of perfluorohexyloctane as a long-term internal tamponade agent in complicated retinal detachment surgery. Am J Ophthalmol 133:95–101

    Article  PubMed  CAS  Google Scholar 

  12. Mandai M, Takanashi T, Ogura Y, Honda Y (1990) Proliferative vitreoretinopathy shows predilection for the inferior fundus. Graefes Arch Clin Exp Ophthalmol 228:335–337

    Article  PubMed  CAS  Google Scholar 

  13. Meinert H, Roy T (2000) Semifluorinated alkanes—a new class of compounds with outstanding properties for use in ophthalmology. Eur J Ophthalmol 10:189–197

    PubMed  CAS  Google Scholar 

  14. Michels RG (1984) Surgery of retinal detachment with proliferative vitreoretinopathy. Retina 4:63–83

    Article  PubMed  CAS  Google Scholar 

  15. No authors listed (1983) The classification of retinal detachment with proliferative vitreoretinopathy. Ophthalmology 90:121–125

    Google Scholar 

  16. Orzalesi N, Migliavacca L, Bottoni F, Miglior S (1998) Experimental short-term tolerance to perfluorodecalin in the rabbit eye: a histological study. Curr Eye Res 17:828–835

    Article  PubMed  CAS  Google Scholar 

  17. Peyman GA, Conway MD, Soike KF, Clark LC Jr (1991) Long-term vitreous replacement in the primates with intravitreal Vitreon or Vitreon plus silicone. Ophthalmic Surg 22:657–664

    PubMed  CAS  Google Scholar 

  18. Peyman GA, Schulman JA, Sullivan B (1995) Perfluorocarbon liquids in ophthalmology. Surv Ophthalmol 39:375–395

    Article  PubMed  CAS  Google Scholar 

  19. Parel JM (1992) Olii di silicone: proprietà fisicochimiche. In: Ryan SJ (ed) Retina, vol. 3 (Italian edition). Medical Books, Palermo, pp 271–289

    Google Scholar 

  20. Sparrow JR, Jayakumar A, Berrocal M, Ozmert E, Chang S (1992) Experimental studies of the combined use of vitreous substitutes of high and low specific gravity. Retina 12:134–140

    PubMed  CAS  Google Scholar 

  21. Stefaniotou MI, Aspiotis MV, Kitsos GD, Kalogeropoulos CD, Asproudis IC, Psila KG (2002) Our experience with perfluorohexyloctane (F6H8) as a temporary endotamponade in vitreoretinal surgery. Eur J Ophthalmol 12:518–522

    PubMed  CAS  Google Scholar 

  22. Tanji TM, Peyman GA, Mehta NJ, Millsap CM (1993) Perfluoroperhydrophenanthrene (Vitreon) as a short-term vitreous substitute after complex vitreoretinal surgery. Ophthalmic Surg 24:681–685

    PubMed  CAS  Google Scholar 

  23. Velikay M, Wedrich A, Stolba U, Datlinger P, Li Y, Binder S (1993) Experimental long-term vitreous replacement with purified and nonpurified perfluorodecalin. Am J Ophthalmol 116:565–570

    PubMed  CAS  Google Scholar 

  24. Velikay M, Stolba U, Wedrich A, Li Y, Datlinger P, Binder S (1995) The effect of chemical stability and purification of perfluorocarbon liquids in experimental extended-term vitreous substitution. Graefes Arch Clin Exp Ophthalmol 233:26–30

    Article  PubMed  CAS  Google Scholar 

  25. Wolf S, Schön V, Meier P, Wiedemann P (2003) Silicone oil-RMN3 mixture (“heavy silicone oil”) as internal tamponade for complicated retinal detachment. Retina 23:335–342

    Article  PubMed  Google Scholar 

  26. Wong D, Lois N (2000) Perfluorocarbons and semifluorinated alkanes. Semin Ophthalmol 15:25–35

    Article  PubMed  CAS  Google Scholar 

  27. Zeana D, Becker J, Kuckelkorn R, Kirchhof B (1999) Perfluorohexyloctane as a long-term vitreous tamponade in the experimental animal. Experimental perfluorohexyloctane substitution. Int Ophthalmol 23:17–24

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgement

We thank Dott. Luciano Lepori, Dr. of physical chemistry, CNR (National Council of Research), Pisa, Italy, for his collaboration regarding the in vitro study.

Author information

Authors and Affiliations

  1. Santa Chiara Hospital, Eye Surgery Clinic, Via Roma 67, 56100, Pisa, Italy

    Stanislao Rizzo, Federica Genovesi-Ebert & Claudia Belting

  2. Via Diaz 86, 55100, Lucca, Italy

    Stanislao Rizzo

Authors
  1. Stanislao Rizzo
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Federica Genovesi-Ebert
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Claudia Belting
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Stanislao Rizzo.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rizzo, S., Genovesi-Ebert, F. & Belting, C. The combined use of perfluorohexyloctane (F6H8) and silicone oil as an intraocular tamponade in the treatment of severe retinal detachment. Graefe's Arch Clin Exp Ophthalmo 244, 709–716 (2006). https://doi.org/10.1007/s00417-006-0317-3

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00417-006-0317-3

Keywords

Search

Navigation