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Protection by iodide of lens from selenite-induced cataract

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Abstract

Background

Iodide has been used empirically against different age-related eye diseases, including cataract. The purpose of the present study was to investigate the effect of iodide on selenite-induced cataract in rat lens.

Methods

Young white rats received subcutaneously sodium selenite (20 and 30 nmol/g b.w.) on day 13 post partum (p.p.). Cataract development was measured by expert estimation and image data analysis. Potassium iodide (1.5 nmol/g b.w.) was given (1–5 times) i.p. at different times with respect to the selenite administration. Lens opacification was analyzed in selenite, selenite–iodide, iodide and control groups on day 7 after selenite administration.

Results

Iodide showed a significant protective effect against selenite cataract when injected 2 days (2 times) before selenite injection, i.e., on days 11 and 12 p.p. No significant effects on lens opacity were found: (1) after only one iodide injection (on day 12 p.p.), (2) after an initial iodide administration 1 h before selenite and (3) after injections of iodide once a day for 5 consecutive days. The protective effect of iodide was the same (about 50%) for both selenite doses used.

Conclusions

There is a time-dependent protective influence of iodide against selenite cataract development. It is supposed that the anticataract effect of iodide could be based on direct or indirect antioxidant mechanisms.

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References

  1. Buchberger W, Winkler R, Moser M, Rieger G (1991) Influence of iodide on cataractogenesis in Emory mice. Ophthalmic Res 23:303–308

    Article  CAS  PubMed  Google Scholar 

  2. Devamanoharan PS, Henein M, Morris S, Ramachandran S, Richards RD, Varma SD (1991) Prevention of selenite cataract by vitamin C. Exp Eye Res 52:563–568

    Article  CAS  PubMed  Google Scholar 

  3. Elstner EF, Adamczyk R, Furch A, Kroner R (1985) Biochemical model reactions for cataract research. Ophthalmic Res 17:302–307

    Article  CAS  PubMed  Google Scholar 

  4. Hillebrand O, Weintrögl G (2001) Handbuch für den Kurarzt. ÖÄK, Vienna

  5. Hockwin O (1997) Multifactorial pathogenesis of senile cataract. Nova Acta Leopoldina NF 75 229:37–44

    Google Scholar 

  6. Ito Y, Cai H, Koizumi Y, Nakao M, Terao M (1999) Correlation between prevention of cataract development by disulfiram and fates of selenium in selenite-treated rats. Curr Eye Res 18:292–299

    Article  CAS  PubMed  Google Scholar 

  7. Jacques PF, Chylack LT Jr (1991) Epidemiologic evidence of a role for the antioxidant vitamins and carotenoids in cataract prevention. Am J Clin Nutr 53:352S–355S

    CAS  PubMed  Google Scholar 

  8. Jacques PF, Chylack LT, Taylor A (1994) Relationships between natural antioxidants and cataract formation. In: Frei B (ed) Natural antioxidants in human health and disease. Academic Press, San Diego, pp 515–533

  9. Micelli-Ferrari T, Vendemiale G, Grattagliano I, Boscia F, Arnese L, Altomare E, Cardia L (1996) Role of lipid peroxidation in the pathogenesis of myopic and senile cataract. Br J Ophthalmol 80:840–843

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Moser M, Buchberger W, Mayer H, Winkler R (1991) Einfluß einer Jodtrinkkur auf den antioxidativen Status von Diabetikern. Wien Klin Wochenschr 103:183–186

    CAS  PubMed  Google Scholar 

  11. Orhan H, Marol S, Hepsen IF, Sahin G (1999) Effects of some probable antioxidants on selenite-induced cataract formation and oxidative stress-related parameters in rats. Toxicology 139:219–232

    Article  CAS  PubMed  Google Scholar 

  12. Prünte C (1999) Katarakt: Ist die Entwicklung beeinflussbar? In: Erb C (ed) Risikofaktoren für Augenerkrankungen: Bedeutung und Behandlung. Huber, Bern, pp 269–275

  13. Rieger G, Winkler R, Buchberger W, Moser M (1995) Iodine distribution in a porcine eye model following iontophoresis. Ophthalmologica 209:84–87

    Article  CAS  PubMed  Google Scholar 

  14. Shearer TR, David LL, Anderson RS (1987) Selenite cataract: a review. Curr Eye Res 6:289–300

    Article  CAS  PubMed  Google Scholar 

  15. Shearer TR, David LL, Anderson RS, Azuma M (1992) Review of selenite cataract. Curr Eye Res 11:357–369

    Article  CAS  PubMed  Google Scholar 

  16. Spector A (1995) Oxidative stress-induced cataract: mechanism of action. FASEB J 9:1173–1182

    CAS  PubMed  Google Scholar 

  17. Varma SD, Chand D, Sharma YR, Kuck JF Jr, Richards RD (1984) Oxidative stress on lens and cataract formation: role of light and oxygen. Curr Eye Res 3:35–57

    Article  CAS  PubMed  Google Scholar 

  18. Winkler R, Moser M, Buchberger W (1989) Einfluß oraler balneotherapeutisch dosierter Jodsolezufuhr auf Harn- und Blutplasma-Jod sowie auf Glutathionspiegel und Aktivitäten korrespondierender Leberenzyme von Ratten. Z Phys Med Baln Med Klim 18:129–136

    Google Scholar 

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Acknowledgement

The study was supported by the Paracelsus Society for Balneology and Iodine Research in Bad Hall, Austria.

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Authors and Affiliations

  1. Emanuel Institute of Biochemical Physics RAS, Kosygin Street 4, 117344, Moscow, Russia

    Konstantin Muranov & Nicolas Poliansky

  2. Paracelsus Society for Balneology and Iodine Research, Bad Hall, Austria

    Rudolf Winkler & Gebhard Rieger

  3. University Eye Hospital, Graz, Austria

    Otto Schmut & Jutta Horwath-Winter

Authors
  1. Konstantin Muranov
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  2. Nicolas Poliansky
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  3. Rudolf Winkler
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  4. Gebhard Rieger
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  5. Otto Schmut
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  6. Jutta Horwath-Winter
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Corresponding author

Correspondence to Konstantin Muranov.

Additional information

In memory of Prof. Otto Hockwin (1925–2002), honorary doctor of the Medical Faculty of the University of Halle, Germany

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Muranov, K., Poliansky, N., Winkler, R. et al. Protection by iodide of lens from selenite-induced cataract. Graefe's Arch Clin Exp Ophthalmol 242, 146–151 (2004). https://doi.org/10.1007/s00417-003-0790-x

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  • DOI: https://doi.org/10.1007/s00417-003-0790-x

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