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Five-year results of trabeculectomy with mitomycin C

  • Clinical Investigation
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Abstract

Background

The long-term efficacy and safety of primary trabeculectomy with mitomycin C were retrospectively studied.

Methods

Sixty eyes of 60 patients with severe glaucoma, 25 female and 35 male, with a mean age of 72.5 years who underwent primary trabeculectomy with mitomycin C between 1993 and 1995 were included. Glaucoma subtypes consisted of 42 patients with primary open-angle glaucoma, 10 patients with normal-pressure glaucoma, 2 patients with chronic narrow-angle glaucoma, 5 patients with pigment dispersion syndrome and 1 patient with pseudoexfoliation syndrome. During surgery, mitomycin C 0.2 mg/ml was applied under the scleral flap for 3 min.

Results

Mean intraocular pressure (IOP) decreased from 22.3±9.3 preoperatively to 12.6±3.5 mmHg postoperatively. With success defined as an IOP level of 15 mmHg or less, a success rate of 83.3% was obtained in the 1st year, dropping to 60% in the 6th year following trabeculectomy. Visual fields remained stable in 73.3% of cases during the follow-up period. LogMAR visual acuity increased from 0.2 to 0.4. Four eyes underwent cataract surgery prior to trabeculectomy. Thirteen eyes underwent cataract surgery during the follow-up period. Long-term complications were relatively mild and consisted of two cases of blebitis. Bleb reconstruction was performed in five eyes with overfiltration or bleb-related complaints.

Conclusions

The present findings indicate that the additional use of mitomycin C may be justified in trabeculectomies in patients with severe glaucoma.

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Authors and Affiliations

  1. University Eye Clinic, Academic Hospital Maastricht, P.O. Box 5800, 6202 AZ , Maastricht, The Netherlands

    Henny J. M. Beckers, Katja C. Kinders & Carroll A. B. Webers

Authors
  1. Henny J. M. Beckers
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  2. Katja C. Kinders
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  3. Carroll A. B. Webers
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Corresponding author

Correspondence to Henny J. M. Beckers.

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Beckers, H.J.M., Kinders, K.C. & Webers, C.A.B. Five-year results of trabeculectomy with mitomycin C. Graefe's Arch Clin Exp Ophthalmol 241, 106–110 (2003). https://doi.org/10.1007/s00417-002-0621-5

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  • DOI: https://doi.org/10.1007/s00417-002-0621-5

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