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Hereditary Neuralgic Amyotrophy (HNA) is genetically heterogeneous

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Abstract

Hereditary Neuralgic Amyotrophy (HNA) is an autosomal dominantly inherited recurrent focal neuropathy affecting mainly the brachial plexus. Linkage to markers on chromosome 17q25 was found in 1996 and subsequent reports confirmed linkage of HNA to this locus. Recently a family with a chronic undulating rather than remitting-relapsing clinical course of HNA was described by a Dutch group. This family did not have linkage to the 17q25 locus. Here we describe for the first time clinically and genetically two families with classic remitting-relapsing HNA that are not linked to the previously described HNA locus on chromosome 17q25. These results demonstrate that clinically homogeneous classical HNA is genetically heterogeneous.

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Authors and Affiliations

  1. Department of Neurology, Westfälische Wilhelms University, Albert Schweitzer Str. 33, 48139 Münster, Germany, Tel.: +49-251/8348178, Fax: +49-251/8348181, E-mail: stogbau@uni-muenster.de, , , , , , DE

    Gregor Kuhlenbäumer, Peter Young, Gert Hünermund & Florian Stögbauer

  2. Department of Molecular Genetics, Flanders Interuniversity Institute for Biotechnology (VIB), University of Antwerp (UIA), Universiteitsplein 1, 2610 Antwerp, Belgium, , , , , , BE

    Jan Meuleman, Peter De Jonghe, Christine Van Broeckhoven & Vincent Timmerman

  3. Department of Clinical Neurophysiology, University Hospital, Kiinamyllynkatu 13, 20520 Turku, Finland, , , , , , FI

    Björn Falck

Authors
  1. Gregor Kuhlenbäumer
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  2. Jan Meuleman
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  3. Peter De Jonghe
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  4. Björn Falck
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  5. Peter Young
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  6. Gert Hünermund
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  7. Christine Van Broeckhoven
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  8. Vincent Timmerman
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  9. Florian Stögbauer
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Additional information

Received: 24 January 2001, Received in revised form: 19 March 2001, Accepted: 4 April 2001

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Kuhlenbäumer, G., Meuleman, J., De Jonghe, P. et al. Hereditary Neuralgic Amyotrophy (HNA) is genetically heterogeneous. J Neurol 248, 861–865 (2001). https://doi.org/10.1007/s004150170070

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  • DOI: https://doi.org/10.1007/s004150170070

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