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Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration

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Abstract

Fluorodopa (FDOPA) and fluorodeoxyglucose (FDG) PET was performed in six patients in early stages of corticobasal degeneration (CBD) and compared to Parkinson’s disease (PD) patients with a similar degree of bradykinesia and rigidity and to healthy controls. Statistical parametric mapping analysis comparing CBD to controls showed metabolic decrease in premotor, primary motor, supplementary motor, primary sensory, prefrontal, and parietal associative cortices, and in caudate and thalamus contralateral to the side of clinical signs. Except for the prefrontal regions a similar metabolic pattern was observed when CBD was compared to PD. Putamen FDOPA uptake was decreased in both CBD and PD. Caudate FDOPA uptake in CBD patients was decreased contralateral to clinical signs when compared to controls, but was higher than in PD. In early stages of CBD, FDOPA and FDG PET patterns differed from those observed in PD. In CBD the asymmetry in FDOPA uptake was less pronounced than that of clinical signs or metabolic impairment.

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Authors and Affiliations

  1. Cyclotron Research Center, and Department of Neurology, University of Liège, B30 Sart Tilman, B-4000 Liège, Belgium e-mail: laureys@pet.crc.ulg.ac.be, Tel.: +32-4-3663687, Fax: +32-4-3662946, , , , , , BE

    S. Laureys, Eric Salmon, Gaetan Garraux & George Franck

  2. Cyclotron Research Center, and Department of Psychology, University of Liège, B30 Sart Tilman, B-4000 Liège, Belgium, , , , , , BE

    Philippe Peigneux

  3. Cyclotron Research Center, University of Liège, B30 Sart Tilman, B-4000 Liège, Belgium, , , , , , BE

    Christian Lemaire & Christian Degueldre

Authors
  1. S. Laureys
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  2. Eric Salmon
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  3. Gaetan Garraux
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  4. Philippe Peigneux
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  5. Christian Lemaire
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  6. Christian Degueldre
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  7. George Franck
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Additional information

Received: 19 January 1999 Received in revised form: 2 July 1999 Accepted: 14 July 1999

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Laureys, S., Salmon, E., Garraux, G. et al. Fluorodopa uptake and glucose metabolism in early stages of corticobasal degeneration. J Neurol 246, 1151–1158 (1999). https://doi.org/10.1007/s004150050534

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  • DOI: https://doi.org/10.1007/s004150050534

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