Skip to main content
Log in

Sez6l2-antibody-associated progressive cerebellar ataxia: a differential diagnosis of atypical parkinsonism

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1

References

  1. Escudero D, Guasp M, Arino H, Gaig C, Martinez-Hernandez E, Dalmau J, Graus F (2017) Antibody-associated CNS syndromes without signs of inflammation in the elderly. Neurology 89:1471–1475

    Article  PubMed  PubMed Central  Google Scholar 

  2. Gaig C, Graus F, Compta Y, Hogl B, Bataller L, Bruggemann N, Giordana C, Heidbreder A, Kotschet K, Lewerenz J, Macher S, Marti MJ, Montojo T, Perez-Perez J, Puertas I, Seitz C, Simabukuro M, Tellez N, Wandinger KP, Iranzo A, Ercilla G, Sabater L, Santamaria J, Dalmau J (2017) Clinical manifestations of the anti-IgLON5 disease. Neurology 88:1736–1743

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Gelpi E, Hoftberger R, Graus F, Ling H, Holton JL, Dawson T, Popovic M, Pretnar-Oblak J, Hogl B, Schmutzhard E, Poewe W, Ricken G, Santamaria J, Dalmau J, Budka H, Revesz T, Kovacs GG (2016) Neuropathological criteria of anti-IgLON5-related tauopathy. Acta Neuropathol 132:531–543

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Miyazaki T, Hashimoto K, Uda A, Sakagami H, Nakamura Y, Saito SY, Nishi M, Kume H, Tohgo A, Kaneko I, Kondo H, Fukunaga K, Kano M, Watanabe M, Takeshima H (2006) Disturbance of cerebellar synaptic maturation in mutant mice lacking BSRPs, a novel brain-specific receptor-like protein family. FEBS Lett 580:4057–4064

    Article  CAS  PubMed  Google Scholar 

  5. Sabater L, Gaig C, Gelpi E, Bataller L, Lewerenz J, Torres-Vega E, Contreras A, Giometto B, Compta Y, Embid C, Vilaseca I, Iranzo A, Santamaria J, Dalmau J, Graus F (2014) A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. Lancet Neurol 13:575–586

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Yaguchi H, Yabe I, Takahashi H, Okumura F, Takeuchi A, Horiuchi K, Kano T, Kanda A, Saito W, Matsumoto M, Nakayama KI, Hatakeyama S, Sasaki H (2014) Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy. J Neurol 261:224–226

    Article  PubMed  Google Scholar 

  7. Yaguchi H, Yabe I, Takahashi H, Watanabe M, Nomura T, Kano T, Matsumoto M, Nakayama KI, Watanabe M, Hatakeyama S (2017) Sez6l2 regulates phosphorylation of ADD and neuritogenesis. Biochem Biophys Res Commun 494:234–241

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

None.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Norbert Brüggemann.

Ethics declarations

Conflicts of interest

The authors declare that they have no competing interests.

Electronic supplementary material

Below is the link to the electronic supplementary material.

Supplementary material 1 (MOV 12880 KB)

Supplementary material 2 (MOV 16607 KB)

Supplementary material 3 (MOV 23917 KB)

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Borsche, M., Hahn, S., Hanssen, H. et al. Sez6l2-antibody-associated progressive cerebellar ataxia: a differential diagnosis of atypical parkinsonism. J Neurol 266, 522–524 (2019). https://doi.org/10.1007/s00415-018-9115-1

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-018-9115-1

Navigation