Abstract
Spreading somatosensory symptoms appearing as Jacksonian sensory march are usually considered to be due to an epileptic seizure. We report on three cases in which these symptoms were caused by thalamic ischemia. Two patients presented with stereotypically recurring hemiparesthesias lasting 2–5 min that gradually spread from the face to the arm and leg on one side. A first cerebral magnetic resonance imaging including DWI was negative in both cases, whereas new thalamic infarctions appeared on repeated imaging when clinical symptoms remained. A third case with a thalamic ischemia did not show recurring events, but also presented with purely sensory spreading symptoms. In all three cases EEG and cardiovascular diagnostics revealed normal results. Pure sensory stroke has previously been described as a result of ischemia of the thalamus or the internal capsule presenting as a sudden onset hemisensory deficit, but spreading symptoms have rarely been reported. According to our observations, thalamic TIAs are an important differential diagnosis of somatosensory epileptic auras presenting with Jacksonian sensory march which require a different clinical management.
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VS, study concept and design, acquisition of data. SL, acquisition of data. BB, imaging data and analysis. HL, study concept and design, critical revision of manuscript for intellectual content.
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Victoria Schubert—reports no disclosures. Dr. Lauxmann reports non-financial support from Eisai, outside the submitted work. Dr. Bender reports non-financial support from Bayer Vital, personal fees from Mevis, outside the submitted work. Dr. Lerche reports grants from German Federal Ministry of Education and Research, grants from Deutsche Forschungsgemeinschaft, during the conduct of the study; personal fees and other from UCB, from Desitin, personal fees and other from BioMarin, personal fees and other from Telethon, personal fees and other from Eisai, grants, personal fees and other from Bial, outside the submitted work.
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All procedures have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.
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Informed consent was obtained from all three patients.
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Schubert, V., Lauxmann, S., Bender, B. et al. Thalamic transitory ischemic attacks presenting as Jacksonian sensory march. J Neurol 264, 2158–2161 (2017). https://doi.org/10.1007/s00415-017-8611-z
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DOI: https://doi.org/10.1007/s00415-017-8611-z