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Clinical and electroencephalographic on–off effect of amantadine in chronic non-traumatic minimally conscious state

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References

  1. Schneider WN, Drew-Cates J, Wong TM, Dombovy ML (1999) Cognitive and behavioural efficacy of amantadine in acute traumatic brain injury: an initial double blind placebo-controlled study. Brain Inj 13:863–872

    Article  CAS  PubMed  Google Scholar 

  2. Meythaler JM, Brunner RC, Johnson A, Novack TA (2002) Amantadine to improve neurorecovery in traumatic brain injury-associated diffuse axonal injury: a pilot double-blind randomized trial. J Head Trauma Rehabil 17:300–313

    Article  PubMed  Google Scholar 

  3. Whyte J, Katz D, Long D, Di Pasquale MC, Polansky M, Kalmar K, Giacino J, Childs N, Mercer W, Novak P, Maurer P, Eifert B (2005) Predictors of outcome in prolonged posttraumatic disorders of consciousness and assessment of medication effects: a multicenter study. Arch Phys Med Rehabil 86:453–462

    Article  PubMed  Google Scholar 

  4. McMahon MA, Vargus-Adams JN, Michaud LJ, Bean J (2009) Effects of amantadine in children with impaired consciousness caused by acquired brain injury: a pilot study. Am J Phys Med Rehabil 88:525–532

    Article  PubMed  Google Scholar 

  5. Giacino JT, Whyte J, Bagiella E, Kalmar K, Childs N, Khademi A, Eifert B, Long D, Katz DI, Cho S, Yablon SA, Luther M, Hammond FM, Nordenbo A, Novak P, Mercer W, Maurer-Karattup P, Sherer M (2012) Placebo-controlled trial of amantadine for severe traumatic brain injury. N Engl J Med 366:819–826. doi:10.1056/NEJMoa1102609

    Article  CAS  PubMed  Google Scholar 

  6. Reynolds JC, Rittenberger JC, Callaway CW (2013) Methylphenidate and amantadine to stimulate reawakening in comatose patients resuscitated from cardiac arrest. Resuscitation 84:818–824

    Article  CAS  PubMed  Google Scholar 

  7. Avecillas-Chasín JM, Barcia JA (2014) Effect of amantadine in minimally conscious state of non-traumatic etiology. Acta Neurochir 156:1375–1377. doi:10.1007/s00701-014-2077-x

    Article  PubMed  Google Scholar 

  8. Schnakers C, Hustinx R, Vandewalle G, Majerus S, Moonen G, Boly M, Vanhaudenhuyse A, Laureys S (2008) Measuring the effect of amantadine in chronic anoxic minimally conscious state. J Neurol Neurosurg Psychiatry 79:225–227. doi:10.1136/jnnp.2007.124099

    Article  CAS  PubMed  Google Scholar 

  9. Giacino JT, Ashwal S, Childs N, Cranford R, Jennett B, Katz DI, Kelly JP, Rosenberg JH, Whyte J, Zafonte RD, Zasler ND (2002) The minimally conscious state: definition and diagnostic criteria. Neurology 58:349–353

    Article  PubMed  Google Scholar 

  10. Bruno MA, Vanhaudenhuyse A, Thibaut A, Moonen G, Laureys S (2011) From unresponsive wakefulness to minimally conscious PLUS and functional locked-in syndromes: recent advances in our understanding of disorders of consciousness. J Neurol 258:1373–1384

    Article  PubMed  Google Scholar 

  11. Giacino JT, Kalmar K, Whyte J (2004) The JFK Coma Recovery Scale-Revised: measurement characteristics and diagnostic utility. Arch Phys Med Rehabil 85:2020–2029

    Article  PubMed  Google Scholar 

  12. Estraneo A, Moretta P, De Tanti A, Gatta G, Giacino J, Trojano L (2014) An Italian multicentre validation study of the Coma Recovery Scale-Revised. Eur J Phys Rehabil Med. (Epub ahead of print)

  13. Forgacs PB, Conte MM, Fridman EA, Voss HU, Victor JD, Schiff ND (2014) Preservation of electroencephalographic organization in patients with impaired consciousness and imaging-based evidence of command-following. Ann Neurol 76:869–879. doi:10.1002/ana.24283

    Article  PubMed Central  PubMed  Google Scholar 

  14. Estraneo A, Moretta P, Loreto V, Lanzillo B, Santoro L, Trojano L (2010) Late recovery after traumatic, anoxic, or hemorrhagic long-lasting vegetative state. Neurology 75:239–245. doi:10.1212/WNL.0b013e3181e8e8cc

    Article  CAS  PubMed  Google Scholar 

  15. Klimesch W, Doppelmayr M, Russegger H, Pachinger T, Schwaiger J (1998) Induced alpha band power changes in the human EEG and attention. Neurosci Lett 244:73–76. doi:10.1016/S0304-3940(98)00122-0

    Article  CAS  PubMed  Google Scholar 

  16. Schiff ND (2010) Recovery of consciousness after brain injury: a mesocircuit hypothesis. Trends Neurosci 33:1–9. doi:10.1016/j.tins.2009.11.002

    Article  PubMed Central  CAS  PubMed  Google Scholar 

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Conflicts of interest

The present research has not been sponsored by any commercial organization. The authors declare that they have no conflict of interest.

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The study was approved by the local Ethics Committee, and performed according to the ethical standards laid down in the 1964 Helsinki Declaration and its later amendments.

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Written informed consent was obtained from the legal guardian of patient.

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Correspondence to A. Estraneo.

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Estraneo, A., Pascarella, A., Moretta, P. et al. Clinical and electroencephalographic on–off effect of amantadine in chronic non-traumatic minimally conscious state. J Neurol 262, 1584–1586 (2015). https://doi.org/10.1007/s00415-015-7771-y

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  • DOI: https://doi.org/10.1007/s00415-015-7771-y

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