Abstract
Laryngeal dystonia (LD) is a task-specific focal dystonia of unknown pathophysiology affecting speech production. We examined the demographics of anecdotally reported alcohol use and its effects on LD symptoms using an online survey based on Research Electronic Data Capture (REDCap™) and National Spasmodic Dysphonia Association’s patient registry. From 641 participants, 531 were selected for data analysis, and 110 were excluded because of unconfirmed diagnosis. A total of 406 patients (76.5 %) had LD and 125 (23.5 %) had LD and voice tremor (LD/VT). The consumption of alcohol was reported by 374 LD (92.1 %) and 109 LD/VT (87.2 %) patients. Improvement of voice symptoms after alcohol ingestion was noted by 227 LD (55.9 % of all patients) and 73 LD/VT (58.4 %), which paralleled the improvement observed by patient’s family and/or friends in 214 LD (57.2 %) and 69 LD/VT (63.3 %) patients. The benefits lasted 1–3 h in both groups with the maximum effect after 2 drinks in LD patients (p = 0.002), whereas LD/VT symptoms improved independent of the consumed amount (p = 0.48). Our data suggest that isolated dystonic symptoms, such as in LD, are responsive to alcohol intake and this responsiveness is not attributed to the presence of VT, which is known to have significant benefits from alcohol ingestion. Alcohol may modulate the pathophysiological mechanisms underlying abnormal neurotransmission of γ-aminobutyric acid (GABA) in dystonia and as such provide new avenues for novel therapeutic options in these patients.
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(2010) Dietary guidelines for Americans. In: Agriculture UDo, Services UDoHaH (eds) US Government Printing Office, Washington, DC
Ali SO, Thomassen M, Schulz GM, Hosey LA, Varga M, Ludlow CL, Braun AR (2006) Alterations in CNS activity induced by botulinum toxin treatment in spasmodic dysphonia: an H215O PET study. J Speech Lang Hear Res 49:1127–1146
Asgeirsson H, Jakobsson F, Hjaltason H, Jonsdottir H, Sveinbjornsdottir S (2006) Prevalence study of primary dystonia in Iceland. Mov Disord 21:293–298
Baylor CR, Yorkston KM, Eadie TL, Maronian NC (2007) The psychosocial consequences of BOTOX injections for spasmodic dysphonia: a qualitative study of patients’ experiences. J Voice 21:231–247
Biary N, Koller W (1985) Effect of alcohol on dystonia. Neurology 35:239–243
Blitzer A (2010) Spasmodic dysphonia and botulinum toxin: experience from the largest treatment series. Eur J Neurol 17(Suppl 1):28–30
Blitzer A, Brin MF, Stewart CF (1998) Botulinum toxin management of spasmodic dysphonia (laryngeal dystonia): a 12-year experience in more than 900 patients. Laryngoscope 108:1435–1441
Boecker H, Wills AJ, Ceballos-Baumann A, Samuel M, Thompson PD, Findley LJ, Brooks DJ (1996) The effect of ethanol on alcohol-responsive essential tremor: a positron emission tomography study. Ann Neurol 39:650–658
Borges V, Ferraz HB, de Andrade LA (2000) Alcohol-sensitive hereditary essential myoclonus with dystonia: a study of 6 Brazilian patients. Neurol Sci 21:373–377
Brin MF, Blitzer A, Stewart C (1998) Laryngeal dystonia (spasmodic dysphonia): observations of 901 patients and treatment with botulinum toxin. Adv Neurol 78:237–252
de Yebenes JG, Vazquez A, Martinez A, Mena MA, del Rio RM, de Felipe C, del Rio J (1988) Biochemical findings in symptomatic dystonias. Adv Neurol 50:167–175
Deuschl G, Wenzelburger R, Loffler K, Raethjen J, Stolze H (2000) Essential tremor and cerebellar dysfunction clinical and kinematic analysis of intention tremor. Brain 123(Pt 8):1568–1580
Frucht SJ, Bordelon Y, Houghton WH, Reardan D (2005) A pilot tolerability and efficacy trial of sodium oxybate in ethanol-responsive movement disorders. Mov Disord 20:1330–1337
Garibotto V, Romito LM, Elia AE, Soliveri P, Panzacchi A, Carpinelli A, Tinazzi M, Albanese A, Perani D (2011) In vivo evidence for GABA(A) receptor changes in the sensorimotor system in primary dystonia. Mov Disord 26:852–857
Gasser T, Bereznai B, Muller B, Pruszak-Seel R, Damrich R, Deuschl G, Oertel WH (1996) Linkage studies in alcohol-responsive myoclonic dystonia. Mov Disord 11:363–370
Gudin M, Vaamonde J, Rodriguez M, Obeso JA (1993) Alcohol sensitive dystonia. Mov Disord 8:122–123
Gurey LE, Sinclair CF, Blitzer A (2013) A new paradigm for the management of essential vocal tremor with botulinum toxin. Laryngoscope 123:2497–2501
Harris P, Taylor R, Theilke R, Payne J, Gonzalez N, Conde J (2009) Research electronic data capture (REDCap)—a metadata driven methodology for providing translational research informatics support. J Biomed Inform 42:377–381
Haslinger B, Erhard P, Dresel C, Castrop F, Roettinger M, Ceballos-Baumann AO (2005) “Silent event-related” fMRI reveals reduced sensorimotor activation in laryngeal dystonia. Neurology 65:1562–1569
Haubenberger D, McCrossin G, Lungu C, Considine E, Toro C, Nahab FB, Auh S, Buchwald P, Grimes GJ, Starling J, Potti G, Scheider L, Kalowitz D, Bowen D, Carnie A, Hallett M (2013) Octanoic acid in alcohol-responsive essential tremor: a randomized controlled study. Neurology 80:933–940
Hedrich K, Meyer EM, Schule B, Kock N, de Carvalho Aguiar P, Wiegers K, Koelman JH, Garrels J, Durr R, Liu L, Schwinger E, Ozelius LJ, Landwehrmeyer B, Stoessl AJ, Tijssen MA, Klein C (2004) Myoclonus-dystonia: detection of novel, recurrent, and de novo SGCE mutations. Neurology 62:1229–1231
Hess C, Saunders-Pullman R (2006) Movement disorders and alcohol misuse. Addict Biol 11:117–125
Izdebski K, Dedo HH, Boles L (1984) Spastic dysphonia: a patient profile of 200 cases. Am J Otolaryngol 5:7–14
Koller WC, Busenbark K, Miner K (1994) The relationship of essential tremor to other movement disorders: report on 678 patients. Essential Tremor Study Group. Ann Neurol 35:717–723
Kyllerman M, Forsgren L, Sanner G, Holmgren G, Wahlstrom J, Drugge U (1990) Alcohol-responsive myoclonic dystonia in a large family: dominant inheritance and phenotypic variation. Mov Disord 5:270–279
Levy LM, Hallett M (2002) Impaired brain GABA in focal dystonia. Ann Neurol 51:93–101
Lim SC, Kim JS, An JY, Yoon Kang S (2012) Alcohol-responsive writer’s cramp. Intern Med 51:99–101
Lof E, Ericson M, Stomberg R, Soderpalm B (2007) Characterization of ethanol-induced dopamine elevation in the rat nucleus accumbens. Eur J Pharmacol 555:148–155
Lou JS, Jankovic J (1991) Essential tremor: clinical correlates in 350 patients. Neurology 41:234–238
Ludlow CL, Adler CH, Berke GS, Bielamowicz SA, Blitzer A, Bressman SB, Hallett M, Jinnah HA, Juergens U, Martin SB, Perlmutter JS, Sapienza C, Singleton A, Tanner CM, Woodson GE (2008) Research priorities in spasmodic dysphonia. Otolaryngol Head Neck Surg 139:495–505
Mahloudji M, Pikielny RT (1967) Hereditary essential myoclonus. Brain 90:669–674
Marjanska M, Lehericy S, Valabregue R, Popa T, Worbe Y, Russo M, Auerbach EJ, Grabli D, Bonnet C, Gallea C, Coudert M, Yahia-Cherif L, Vidailhet M, Meunier S (2013) Brain dynamic neurochemical changes in dystonic patients: a magnetic resonance spectroscopy study. Mov Disord 28:201–209
Meyer TK, Hu A, Hillel AD (2013) Voice disorders in the workplace: productivity in spasmodic dysphonia and the impact of botulinum toxin. Laryngoscope 123(Suppl 6):S1–S14
Mubaidin AF (2000) Alcohol with xylocaine for treatment of eyelid dystonia. Eur J Neurol 7:213–215
Nestoros JN (1980) Ethanol specifically potentiates GABA-mediated neurotransmission in feline cerebral cortex. Science 209:708–710
Novakovic D, Waters HH, D’Elia JB, Blitzer A (2011) Botulinum toxin treatment of adductor spasmodic dysphonia: longitudinal functional outcomes. Laryngoscope 121:606–612
Quinn NP (1996) Essential myoclonus and myoclonic dystonia. Mov Disord 11:119–124
Ridding MC, Sheean G, Rothwell JC, Inzelberg R, Kujirai T (1995) Changes in the balance between motor cortical excitation and inhibition in focal, task specific dystonia. J Neurol Neurosurg Psychiatry 59:493–498
Schweinfurth JM, Billante M, Courey M (2002) Risk factors and demographics in patients With spasmodic dysphonia. Laryngoscope 112:220–223
Simonyan K, Berman BD, Herscovitch P, Hallett M (2013) Abnormal striatal dopaminergic neurotransmission during rest and task production in spasmodic dysphonia. J Neurosci 33:14705–14714
Simonyan K, Frucht SJ (2013) Long-term effect of sodium oxybate (Xyrem®) in spasmodic dysphonia with vocal tremor. Tremor Other Hyperkinet Mov (N Y)
Simonyan K, Ludlow CL (2010) Abnormal activation of the primary somatosensory cortex in spasmodic dysphonia: an fMRI study. Cereb Cortex 20:2749–2759
Simonyan K, Ludlow CL (2012) Abnormal structure-function relationship in spasmodic dysphonia. Cereb Cortex 22:417–425
Simonyan K, Tovar-Moll F, Ostuni J, Hallett M, Kalasinsky VF, Lewin-Smith MR, Rushing EJ, Vortmeyer AO, Ludlow CL (2008) Focal white matter changes in spasmodic dysphonia: a combined diffusion tensor imaging and neuropathological study. Brain 131:447–459
Sulica L, Louis ED (2010) Clinical characteristics of essential voice tremor: a study of 34 cases. Laryngoscope 120:516–528
Valente EM, Misbahuddin A, Brancati F, Placzek MR, Garavaglia B, Salvi S, Nemeth A, Shaw-Smith C, Nardocci N, Bentivoglio AR, Berardelli A, Eleopra R, Dallapiccola B, Warner TT (2003) Analysis of the epsilon-sarcoglycan gene in familial and sporadic myoclonus-dystonia: evidence for genetic heterogeneity. Mov Disord 18:1047–1051
White LJ, Klein AM, Hapner ER, Delgaudio JM, Hanfelt JJ, Jinnah HA, Johns MM 3rd (2011) Coprevalence of tremor with spasmodic dysphonia: a case-control study. Laryngoscope 121:1752–1755
Ziemann U, Lonnecker S, Paulus W (1995) Inhibition of human motor cortex by ethanol. A transcranial magnetic stimulation study. Brain 118(Pt 6):1437–1446
Acknowledgments
We thank Estee Rubien-Thomas, BA, and Peter Velickovic for their assistance in data collection. This study was funded by the grant from the National Institute on Deafness and Other Communication Disorders, National Institutes of Health (R01DC012545) to KS. ClinicalTrials.gov Identifier: NCT01961297. DNK was supported by a research fellowship grant from the Foundation for Surgery Reg Worcester Research Fellowship Scholarship, Royal Australasian College of Surgeons.
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Kirke, D.N., Frucht, S.J. & Simonyan, K. Alcohol responsiveness in laryngeal dystonia: a survey study. J Neurol 262, 1548–1556 (2015). https://doi.org/10.1007/s00415-015-7751-2
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DOI: https://doi.org/10.1007/s00415-015-7751-2