Skip to main content
SpringerLink
Log in

Antiphospholipid antibodies: a possible biomarker of disease activity in multiple sclerosis and neuromyelitis optica spectrum disorders

  • Letter to the Editors
  • Published:
Journal of Neurology Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Iong Y, He Y, Zheng Y, Chen M, Zhang B, Gao C (2013) Serum anticardiolipin antibodies in patients with neuromyelitis optica spectrum disorder. J Neurol 260(12):3150–3157

    Article  Google Scholar 

  2. Wu L, Huang D, Yang Y, Wu W (2014) Combined screening for serum anti-nuclear and anti-aquaporin-4 antibodies improves diagnostic accuracy for distinguishing neuromyelitis optica from multiple sclerosis. Eur Neurol 72(1–2):103–108

    Article  CAS  PubMed  Google Scholar 

  3. Koudriavtseva T, D’Agosto G, Mandoj C, Sperduti I, Cordiali-Fei P (2014) High frequency of antiphospholipid antibodies in relapse of multiple sclerosis: a possible indicator of inflammatory-thrombotic processes. Neurol Sci. doi:10.1007/s10072-014-1823-4

  4. Spadaro M, Amendolea MA, Mazzucconi MG, Fantozzi R, Di Lello R, Zangari P, Masala G (1999) Autoimmunity in multiple sclerosis: study of a wide spectrum of autoantibodies. Mult Scler 5(2):121–125

    Article  CAS  PubMed  Google Scholar 

  5. Garg N, Zivadinov R, Ramanathan M, Vasiliu I, Locke J, Watts K, Lema J, Rajeswary J, Munschauer FE, Ambrus J Jr, Weinstock-Guttman B (2007) Clinical and MRI correlates of autoreactive antibodies in multiple sclerosis patients. J Neuroimmunol 187(1–2):159–165

    Article  CAS  PubMed  Google Scholar 

  6. Bidot CJ, Horstman LL, Jy W, Jimenez JJ, Bidot C Jr, Ahn YS, Alexander JS, Gonzalez-Toledo E, Kelley RE, Minagar A (2007) Clinical and neuroimaging correlates of antiphospholipid antibodies in multiple sclerosis: a preliminary study. BMC Neurol 7:36

    Article  PubMed Central  PubMed  Google Scholar 

  7. Zivadinov R, Ramanathan M, Ambrus J, Hussein S, Ramasamy DP, Dwyer MG, Bergsland N, Minagar A, Weinstock-Guttman B (2012) Anti-phospholipid antibodies are associated with response to interferon-beta1a treatment in MS: results from a 3-year longitudinal study. Neurol Res 34(8):761–769. doi:10.1179/1743132812Y.0000000076

    Article  CAS  PubMed  Google Scholar 

  8. Brunetti A, Ricchieri GL, Patrassi GM, Girolami A, Tavolato B (1981) Rheological and fibrinolytic findings in multiple sclerosis. J Neurol Neurosurg Psychiatry 44(4):340–343

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  9. Kirichuk VF, Streknev AG (2003) The role of hemostasis system in the pathogenesis and course of multiple sclerosis. Zh Nevrol Psikhiatr Im S S Korsakova (Spec No 2):34–38

    Google Scholar 

  10. Aksungar FB, Topkaya AE, Yildiz Z, Sahin S, Turk U (2008) Coagulation status and biochemical and inflammatory markers in multiple sclerosis. J Clin Neurosci 15(4):393–397. doi:10.1016/j.jocn.2007.02.090

    Article  CAS  PubMed  Google Scholar 

  11. Campos-de-Magalhães M, de Almeida AJ, Papaiz-Alvarenga RM, Gadelha T, Morais-de-Sá CA, Alves-Leon SV (2009) Normal plasma antithrombin activity in patients with relapsing-remitting and secondary progressive multiple sclerosis. Clin Neurol Neurosurg 111(5):407–411. doi:10.1016/j.clineuro.2008.11.016

    Article  PubMed  Google Scholar 

  12. Ingram G, Hakobyan S, Hirst CL, Harris CL, Loveless S, Mitchell JP, Pickersgill TP, Robertson NP, Morgan BP (2012) Systemic complement profiling in multiple sclerosis as a biomarker of disease state. Mult Scler 18(10):1401–1411

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  13. Festoff BW, Li C, Woodhams B, Lynch S (2012) Soluble thrombomodulin levels in plasma of multiple sclerosis patients and their implication. J Neurol Sci 323(1–2):61–65. doi:10.1016/j.jns.2012.08.008

    Article  CAS  PubMed  Google Scholar 

  14. Koudriavtseva T (2014) Thrombotic processes in multiple sclerosis as manifestation of innate immune activation. Front Neurol 5:119. doi:10.3389/fneur.2014.00119

    Article  PubMed Central  PubMed  Google Scholar 

  15. Renaud M, Aupy J, Uring-Lambert B, Chanson JB, Collongues N, Blanc F, De Sèze J (2014) Isolated anti-β2-glycoprotein I antibodies in neurology: a frontier syndrome between multiple sclerosis and antiphospholipid syndrome? Eur J Neurol 21(6):901–906. doi:10.1111/ene.12408

    Article  CAS  PubMed  Google Scholar 

  16. Sastre-Garriga Reverter JC, Font J, Tintoré M, Espinosa G, Montalban X (2001) Anticardiolipin antibodies are not a useful screening tool in a nonselected large group of patients with multiple sclerosis. Ann Neurol 49(3):408–411

    Article  CAS  PubMed  Google Scholar 

Download references

Conflicts of interest

No conflict of interest or financial interest is reported. T. Koudriavtseva reports consulting fees from Bayer Schering, and Institutional grant from Merck Serono, Biogen Idec, Novartis, Bayer Schering outside the submitted work. Other authors have nothing to declare.

Ethical standard

All human studies must state that they have been approved by the appropriate ethics committee and have therefore been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki.

Author information

Authors and Affiliations

  1. Multiple Sclerosis Center, Unit of Neurology, Regina Elena National Cancer Institute, IFO, Via Elio Chianesi 53, 00144, Rome, Italy

    Tatiana Koudriavtseva, Domenico Plantone & Rosaria Renna

Authors
  1. Tatiana Koudriavtseva
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Domenico Plantone
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Rosaria Renna
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Tatiana Koudriavtseva.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Koudriavtseva, T., Plantone, D. & Renna, R. Antiphospholipid antibodies: a possible biomarker of disease activity in multiple sclerosis and neuromyelitis optica spectrum disorders. J Neurol 261, 2028–2029 (2014). https://doi.org/10.1007/s00415-014-7506-5

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00415-014-7506-5

Keywords

Search

Navigation