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Genetic association of sirtuin genes and Parkinson’s disease

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Abstract

Parkinson’s disease (PD) is a neurodegenerative disease caused by both genetic and environmental factors. Sirtuins are highly-conserved, NAD-dependent class III deacetylases that regulate a variety of cellular functions. Most of the known sirtuins have been involved in animal models of neurodegenerative disorders, such as PD. Although seven sirtuin family members have been identified (SIRT1–SIRT7) the relationship between sirtuins and PD in humans has not been established. Our aim was to investigate the association between sirtuin genes and risk of PD. We included 326 PD patients and 371 controls from southern Spain. Forty-one single nucleotide polymorphisms (SNPs) in sirtuin genes were genotyped in order to determine whether they were related to the risk of PD. These SNPs included Tag-SNPs, coding non-synonymous SNPs and SNPs affecting activity of microRNA binding sites. No relationship was found between these SNPs in sirtuin genes and PD. Our data indicate that variations in sirtuin genes do not affect the risk for PD, at least in our population.

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Acknowledgments

We would like to thank the patients and healthy individuals who participated in this study. We would also like to thank Raquel Gómez, from the Genomic Service of the Instituto de Biomedicina de Sevilla (IBiS), for her technical support. This work was supported by grants from the Ministerio de Economía y Competitividad de España [SAF2007-60700]; the Instituto de Salud Carlos III [PI10/01674, CP08/00174], the Consejería de Economía, Innovación, Ciencia y Empleo de la Junta de Andalucía [CVI-02526, CTS-7685], the Consejería de Salud y Bienestar Social de la Junta de Andalucía [PI-0377/2007, PI-0741/2010, PI-0437-2012], the Sociedad Andaluza de Neurología, the Jacques and Gloria Gossweiler Foundation and the Fundación Alicia Koplowitz. Pilar Gómez-Garre was supported by the “Miguel Servet” program from the Instituto de Salud Carlos III.

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Authors and Affiliations

  1. Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla/Instituto de Biomedicina de Sevilla (IBiS), Av. Manuel Siurot s/n, 41013, Seville, Spain

    Silvia Jesús, Pilar Gómez-Garre, Fátima Carrillo, María T. Cáceres-Redondo, Ismael Huertas-Fernández, Inmaculada Bernal-Bernal, Marta Bonilla-Toribio, Laura Vargas-González, Manuel Carballo & Pablo Mir

  2. Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain

    Pilar Gómez-Garre & Pablo Mir

Authors
  1. Silvia Jesús
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  2. Pilar Gómez-Garre
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  3. Fátima Carrillo
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  4. María T. Cáceres-Redondo
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  5. Ismael Huertas-Fernández
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  6. Inmaculada Bernal-Bernal
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  7. Marta Bonilla-Toribio
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  8. Laura Vargas-González
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  9. Manuel Carballo
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  10. Pablo Mir
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Corresponding author

Correspondence to Pablo Mir.

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Jesús, S., Gómez-Garre, P., Carrillo, F. et al. Genetic association of sirtuin genes and Parkinson’s disease. J Neurol 260, 2237–2241 (2013). https://doi.org/10.1007/s00415-013-6970-7

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  • DOI: https://doi.org/10.1007/s00415-013-6970-7

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