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Association between polymorphism in the promoter region of Interleukin 6 (-174 G/C) and risk of Alzheimer’s disease: a meta-analysis

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Abstract

Studies of the relationship between Alzheimer’s disease (AD) and polymorphism in the promoter region of Interleukin 6 (IL-6) -174 G/C have reported inconsistent results. To assess the association between IL-6 -174 G/C promoter polymorphism and AD risk, a meta-analysis containing 3,101 AD cases and 3,860 controls from 18 case–control studies was performed. There were 16 studies involving Europeans and 2 studies involving non-Europeans. The combined results showed significant differences in recessive model [CC versus GC + GG, odds ratio (OR) = 0.70, 95% confidence interval (CI) = 0.54–0.90] and heterozygote comparison (CC versus GC, OR = 0.76, 95% CI = 0.60–0.96) on the basis of all studies. On subgroup analysis by ethnicity, similarly significant differences in recessive model (CC versus GC + GG) were found in both Europeans and non-Europeans, but significant difference in heterozygote comparison (CC versus GC) was found only in non-Europeans. In conclusion, there were statistically significant differences in genotype distribution of IL-6 -174 G/C between AD cases and controls in recessive model (CC versus GC + GG). Genotype CC of IL-6 -174 G/C could decrease the risk of AD. Further studies with large sample size, especially in subgroup analysis, should be done.

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Acknowledgments

This work was supported by National Natural Science Foundation of China grant 30800441.

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Authors and Affiliations

  1. Department of Medical Genetics, College of Basic Medical Science, Third Military Medical University, Gaotanyan St., Shapingba District, Chongqing, 400038, People’s Republic of China

    Limeng Dai, Dan Liu, Hong Guo, Yanyan Wang & Yun Bai

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  1. Limeng Dai
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  2. Dan Liu
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  3. Hong Guo
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  4. Yanyan Wang
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  5. Yun Bai
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Correspondence to Yun Bai.

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Dai, L., Liu, D., Guo, H. et al. Association between polymorphism in the promoter region of Interleukin 6 (-174 G/C) and risk of Alzheimer’s disease: a meta-analysis. J Neurol 259, 414–419 (2012). https://doi.org/10.1007/s00415-011-6164-0

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  • DOI: https://doi.org/10.1007/s00415-011-6164-0

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