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A case of glycine-receptor antibody-associated encephalomyelitis with rigidity and myoclonus (PERM): clinical course, treatment and CSF findings

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References

  1. Meinck HM, Thompson PD (2002) Stiff man syndrome and related condition. Mov Disord 17(5):853–866

    Article  PubMed  Google Scholar 

  2. Hutchinson M, Waters P, McHugh J, Gorman G, O’Riordan S, Connolly S, Hager H, Yu P, Becker CM, Vincent A (2008) Progressive encephalomyelitis, rigidity, and myoclonus: a novel glycine receptor antibody. Neurology 71(16):1291–1292

    Article  PubMed  CAS  Google Scholar 

  3. Graus F, Delattre JY, Antoine JC, Dalmau J, Giometto B, Grisold W, Honnorat J, Sillevis Smitt P, Vedeler CH, Verschuuren JJGM, Vincent A, Voltz R (2004) Recommended diagnostic criteria for paraneoplastic neurological syndromes. J Neurol Neurosurg Psychiatry 75:1135–1140

    Article  PubMed  CAS  Google Scholar 

  4. Hadjivassiliou M, Aeschlimann D, Grünewald RA, Sanders DS, Sharrack B, Woodroofe N (2010) GAD antibody-associated neurological illness and its relationship to gluten sensitivity. Acta Neurol Scand (Epub ahead of print). doi: 10.1111/j.1600-0404.2010.01356.x

  5. Meinck HM, Faber L, Morgenthaler N, Seissler J, Maile S, Butler M, Solimena M, DeCamilli P, Scherbaum WA (2001) Antibodies against glutamic acid decarboxylase: prevalence in neurological diseases. J Neurol Neurosurg Psychiatry 71(1):100–103

    Article  PubMed  CAS  Google Scholar 

  6. Meinck HM, Ricker K, Hülser PJ, Schmid E, Peiffer J, Solimena M (1994) Stiff man syndrome: clinical and laboratory findings in eight patients. J Neurol 241(3):157–166

    Article  PubMed  CAS  Google Scholar 

  7. Murinson BB, Butler M, Marfurt K, Gleason S, De Camilli P, Solimena M (2004) Markedly elevated GAD antibodies in SPS: effects of age and illness duration. Neurology 63(11):2146–2148

    PubMed  CAS  Google Scholar 

  8. Kraemer M, Berlit P (2008) Progressive encephalomyelitis with rigidity and myoclonus in an 81-year-old patient. Clin Neurol Neurosurg 110(3):279–281

    Article  PubMed  Google Scholar 

  9. Schmidt C, Freilinger T, Lieb M, Rémi J, Klein M, Straube A, Pfefferkorn T (2010) Progressive encephalomyelitis with rigidity and myoclonus preceding otherwise asymptomatic Hodgkin’s lymphoma. J Neurol Sci 291(1–2):118–120

    Article  PubMed  Google Scholar 

  10. Saiz A, Blanco Y, Sabater L, González F, Bataller L, Casamitjana R, Ramió-Torrentà L, Graus F (2008) Spectrum of neurological syndromes associated with glutamic acid decarboxylase antibodies: diagnostic clues for this association. Brain 131:2553–2563

    Article  PubMed  Google Scholar 

  11. Dalakas MC (2005) The role of IVIg in the treatment of patients with stiff person syndrome and other neurological diseases associated with anti-GAD antibodies. J Neurol 252(S1):1/19–1/25

    Article  CAS  Google Scholar 

  12. Mas N, Saiz A, Leite MI, Warers P, Baron M, Castano D, Sabater L, Vincent A, Graus F (2010) Antiglycine-receptor encephalomyelitis with rigidity. J Neurol Neurosurg Psychiatry (Epub ahead of print). doi: 10.1136/2010.229104

  13. Thümen A, Moser A (2010) An uncommon paraneoplastic Ri-positive opsoclonus-myoclonus-like syndrome and Stiff-person syndrome with elevated glutamate/GABA ratio in the cerebrospinal fluid after breast cancer. J Neurol 257(7):1215–1217

    Article  PubMed  Google Scholar 

  14. Dalakas MC, Li M, Fujii M, Jacobowitz DM (2001) Stiff person syndrome: quantification, specificity, and intrathecal synthesis of GAD65 antibodies. Neurology 57(5):780–784

    PubMed  CAS  Google Scholar 

  15. Dubowitz LMS, Bouza H, Hird MF, Jacken J (1992) Low cerebrospinal fluid concentration of free gamma-aminobutyric acid in startle disease. Lancet 340:80–81

    Article  PubMed  CAS  Google Scholar 

  16. Stephenson JBP (1992) Vigabatrin for startle disease with altered cerebrospinal-fluid free gamma-aminobutyric acid. Lancet 340:430–431

    Article  PubMed  CAS  Google Scholar 

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Piotrowicz, A., Thümen, A., Leite, M.I. et al. A case of glycine-receptor antibody-associated encephalomyelitis with rigidity and myoclonus (PERM): clinical course, treatment and CSF findings. J Neurol 258, 2268–2270 (2011). https://doi.org/10.1007/s00415-011-6078-x

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  • DOI: https://doi.org/10.1007/s00415-011-6078-x

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