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Homology between Klebsiella pneumoniae and human aquaporin-4: no evidence for cross-reactivity in neuromyelitis optica. A study on 114 patients

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References

  1. Jarius S, Wildemann B (2007) Neuromyelitis optica. Nervenarzt 78:1365–1377

    Article  PubMed  CAS  Google Scholar 

  2. Wingerchuk DM, Lennon VA, Pittock SJ, Lucchinetti CF, Weinshenker BG (2006) Revised diagnostic criteria for neuromyelitis optica. Neurology 66:1485–1489

    Article  PubMed  CAS  Google Scholar 

  3. Jarius S, Franciotta D, Bergamaschi R, Wright H, Littleton E, Palace J, Hohlfeld R, Vincent A (2007) NMO-IgG in the diagnosis of neuromyelitis optica. Neurology 68:1076–1077

    Article  PubMed  CAS  Google Scholar 

  4. Jarius S, Probst C, Borowski K, Franciotta D, Wildemann B, Stoecker W, Wandinger KP (2010) Standardized method for the detection of antibodies to aquaporin-4 based on a highly sensitive immunofluorescence assay employing recombinant target antigen. J Neurol Sci 291:52–56

    Article  PubMed  CAS  Google Scholar 

  5. Lennon VA, Wingerchuk DM, Kryzer TJ, Pittock SJ, Lucchinetti CF, Fujihara K, Nakashima I, Weinshenker BG (2004) A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis. Lancet 364:2106–2112

    Article  PubMed  CAS  Google Scholar 

  6. Paul F, Jarius S, Aktas O, Bluthner M, Bauer O, Appelhans H, Franciotta D, Bergamaschi R, Littleton E, Palace J, Seelig HP, Hohlfeld R, Vincent A, Zipp F (2007) Antibody to aquaporin 4 in the diagnosis of neuromyelitis optica. PLoS Med 4:e133

    Article  PubMed  Google Scholar 

  7. Waters P, Jarius S, Littleton E, Leite MI, Jacob S, Gray B, Geraldes R, Vale T, Jacob A, Palace J, Maxwell S, Beeson D, Vincent A (2008) Aquaporin-4 antibodies in neuromyelitis optica and longitudinally extensive transverse myelitis. Arch Neurol 65:913–919

    Article  PubMed  Google Scholar 

  8. Jarius S, Paul F, Franciotta D, Waters P, Zipp F, Hohlfeld R, Vincent A, Wildemann B (2008) Aquaporin-4 antibodies in neuromyelitis optica. Nat Clin Pract Neurol 4:202–214

    PubMed  CAS  Google Scholar 

  9. Jarius S, Wildemann B (2010) AQP4 antibodies in neuromyelitis optica: diagnostic and pathogenetic relevance. Nat Rev Neurol 6:383–392

    Article  PubMed  CAS  Google Scholar 

  10. Tani T, Sakimura K, Tsujita M, Nakada T, Tanaka M, Nishizawa M, Tanaka K (2009) Identification of binding sites for anti-aquaporin 4 antibodies in patients with neuromyelitis optica. J Neuroimmunol 211:110–113

    Article  PubMed  CAS  Google Scholar 

  11. Sellner J, Hemmer B, Muhlau M (2010) The clinical spectrum and immunobiology of parainfectious neuromyelitis optica (Devic) syndromes. J Autoimmun 34:371–379

    Google Scholar 

  12. Altschul SF, Madden TL, Schaffer AA, Zhang J, Zhang Z, Miller W, Lipman DJ (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res 25:3389–3402

    Article  PubMed  CAS  Google Scholar 

  13. Lu M, Lee MD, Smith BL, Jung JS, Agre P, Verdijk MA, Merkx G, Rijss JP, Deen PM (1996) The human AQP4 gene: definition of the locus encoding two water channel polypeptides in brain. Proc Natl Acad Sci USA 93:10908–10912

    Article  PubMed  CAS  Google Scholar 

  14. Tiwana H, Natt RS, Benitez-Brito R, Shah S, Wilson C, Bridger S, Harbord M, Sarner M, Ebringer A (2001) Correlation between the immune responses to collagens type I, III, IV and V and Klebsiella pneumoniae in patients with Crohn’s disease and ankylosing spondylitis. Rheumatology (Oxford) 40:15–23

    Article  CAS  Google Scholar 

  15. Lee HS, Choi KD, Lee JE, Park HK (2009) Optic neuritis after Klebsiella pneumonitis and liver abscess. J Neuroophthalmol 29:134–135

    Google Scholar 

  16. Reuss R, Rommer PS, Bruck W, Paul F, Bolz M, Jarius S, Boettcher T, Grossmann A, Bock A, Zipp F, Benecke R, Zettl UK (2009) A woman with acute myelopathy in pregnancy: case presentation. BMJ 339:b3862

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Acknowledgments

This work was supported by a Research Fellowship from the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) to S.J., and by research grants from Bayer Schering Pharma and from Merck Serono to S.J. and B.W. The cells used in this study were kindly provided by Euroimmun, Luebeck, Germany.

Conflict of interest

KPW and SP are employees of Euroimmun, Luebeck. SJ and BW declare no conflict of interest. Euroimmun had no influence on study design and the decision to publish this manuscript.

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Authors and Affiliations

  1. Division of Molecular Neuroimmunology, Department of Neurology, University of Heidelberg, Heidelberg, Germany

    S. Jarius & B. Wildemann

  2. Institute for Experimental Immunology, Affiliated to Euroimmun, Luebeck, Germany

    K. P. Wandinger & S. Platzer

  3. Institute for Neuroimmunology and Clinical MS Research, Center for Molecular Neurobiology Hamburg (ZMNH), University Medical Center Eppendorf, Hamburg, Germany

    K. P. Wandinger

Authors
  1. S. Jarius
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  2. K. P. Wandinger
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  3. S. Platzer
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  4. B. Wildemann
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Corresponding author

Correspondence to B. Wildemann.

Additional information

S. Jarius and K. P. Wandinger contributed equally.

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Jarius, S., Wandinger, K.P., Platzer, S. et al. Homology between Klebsiella pneumoniae and human aquaporin-4: no evidence for cross-reactivity in neuromyelitis optica. A study on 114 patients. J Neurol 258, 929–931 (2011). https://doi.org/10.1007/s00415-010-5839-2

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  • DOI: https://doi.org/10.1007/s00415-010-5839-2

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