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Severe encephalopathy and polyneuropathy induced by dichloroacetate

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References

  1. Coglan A (2007) Cheap, ‘safe’ drug kills most cancers. New Scientist magazine 11

  2. Bonnet S, Archer SL, Allalunis-Turner J et al (2007) A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. Cancer Cell 11:37–51

    Article  CAS  PubMed  Google Scholar 

  3. Michelakis ED, Webster L, Mackey JR (2008) Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br J Cancer 99:989–994

    Article  CAS  PubMed  Google Scholar 

  4. Michelakis ED, Sutendra G, Dromparis P et al (2010) Metabolic modulation of glioblastoma with dichloroacetate. Sci Transl Med 2(31):31–34

    Google Scholar 

  5. Stacpoole PW, Kerr DS, Barnes C et al (2006) Controlled clinical trial of dichloroacetate for treatment of congenital lactic acidosis in children. Pediatrics 117:1519–1531

    Article  PubMed  Google Scholar 

  6. Kaufmann P, Engelstad K, Wei Y et al (2006) Dichloroacetate causes toxic neuropathy in MELAS: a randomized, controlled clinical trial. Neurology 66:324–330

    Article  CAS  PubMed  Google Scholar 

  7. Shroads AL, Guo X, Dixit V, Liu HP, James MO, Stacpoole PW (2008) Age-dependent kinetics and metabolism of dichloroacetate: possible relevance to toxicity. J Pharmacol Exp Ther 324:1163–1171

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Neuro-oncology, Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands

    Dieta Brandsma & Willem Boogerd

  2. Department of Neurology, Slotervaart Hospital, Amsterdam, The Netherlands

    Dieta Brandsma & Willem Boogerd

  3. Department of Pharmacy & Pharmacology, Slotervaart Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Thomas P. C. Dorlo & Jos H. Beijnen

  4. Department of Medical Oncology, Antoni van Leeuwenhoek Hospital/The Netherlands Cancer Institute, Amsterdam, The Netherlands

    Haanen John H.

Authors
  1. Dieta Brandsma
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  2. Thomas P. C. Dorlo
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  3. Haanen John H.
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  4. Jos H. Beijnen
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  5. Willem Boogerd
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Correspondence to Dieta Brandsma.

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Brandsma, D., Dorlo, T.P.C., Haanen, J.H. et al. Severe encephalopathy and polyneuropathy induced by dichloroacetate. J Neurol 257, 2099–2100 (2010). https://doi.org/10.1007/s00415-010-5654-9

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  • DOI: https://doi.org/10.1007/s00415-010-5654-9

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