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Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study

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Abstract

The PRIAMO study is a cross-sectional longitudinal observational study aimed at describing epidemiology and evolution of non-motor symptoms (NMS) in patients with different forms of parkinsonism recruited in 55 Italian centres and evaluated over 24 months. In this paper, we are reporting prevalence and clinical characteristics of NMS in patients with atypical and secondary parkinsonism. Out of 1307 consecutive patients with a diagnosis of parkinsonism, 83 patients had vascular parkinsonism (VP), 34 had multiple system atrophy (MSA), 30 had progressive supranuclear palsy (PSP), 14 had dementia with Lewy bodies (DLB) and 11 had corticobasal degeneration (CBD). MSA and DLB had the highest number of NMS domains and symptoms, respectively. Gastrointestinal symptoms, pain, urinary problems and postural instability due to orthostatic hypotension were most frequent in MSA. Sleep disturbances were also common with a prevalence of approximately 70% in all diagnostic groups but CBD (36%). Psychiatric symptoms and attention and memory impairment were frequently observed in all diagnoses but were most prevalent among DLB patients, whereas the prevalence of skin and respiratory disorders was rather low in all forms, ranging between 10 and 30%. Atypical parkinsonism patients also reported a low QoL, with no significant differences among the different forms, whereas PD and VP patients had a better QoL.

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Acknowledgments

This study was supported by an educational grant issued by Boehringer-Ingelheim, Italy. L. Simoni is an employee of Medidata s.r.l.

Author information

Authors and Affiliations

  1. Dipartimento di Scienze Neurologiche, Sapienza Università di Roma, V.le dell’Università 30, 00185, Rome, Italy

    Carlo Colosimo & Giuseppe Meco

  2. Dipartimento di Neuroscienze, Scienze Psichiatriche ed Anestesiologiche, Università di Messina, Messina, Italy

    Letterio Morgante

  3. Parkinson Institute, Istituti Clinici di Perfezionamento, Milan, Italy

    Angelo Antonini

  4. Università Federico II and IDC-Hermitage-Capodimonte, Naples, Italy

    Paolo Barone

  5. Neurologia, Ospedale Villa Sofia CTO, Palermo, Italy

    Tania P. Avarello

  6. U.O. di Neurologia, Ospedale Regionale, Aosta, Italy

    Edo Bottacchi

  7. Clinica Neurologica, Policlinico Universitario, Monserrat, Cagliari, Italy

    Antonino Cannas

  8. Clinica di Neuroriabilitazione, Ospedale Umberto I, Ancona, Italy

    Maria Gabriella Ceravolo

  9. Neurologia, Ospedale Santa Chiara, Pisa, Italy

    Roberto Ceravolo

  10. Neurologia e Stroke, A.O.R.N. San Giuseppe Moscati, Avellino, Italy

    Giulio Cicarelli

  11. U.O. di Neurologia, Azienda Ospedaliera S.Giovanni di Dio, Agrigento, Italy

    Rosa M. Gaglio

  12. Neurologia, Azienda Ospedaliera S. Elia, Caltanissetta, Italy

    Luisa Giglia

  13. U.O. di Neurologia, Ospedale Guzzardi, Vittoria, Ragusa, Italy

    Francesco Iemolo

  14. Fondazione Salvatore Maugeri IRCCS, Castel Goffredo (MN), Italy

    Michela Manfredi

  15. Clinica Neurologica I, Policlinico Universitario, Catania, Italy

    Alessandra Nicoletti

  16. Neurologia, Ospedale Civile, Vimercate, Italy

    Massimo Pederzoli

  17. Neurologia, Presidio Ospedaliero Annunziata, Cosenza, Italy

    Alfredo Petrone

  18. Policlinico Tor Vergata, Fondazione Santa Lucia, IRCCS, Rome, Italy

    Antonio Pisani

  19. Ospedale Sant’Andrea, Sapienza Università di Roma, Rome, Italy

    Francesco E. Pontieri

  20. Neurologia Dipartimento Neuroscienze applicate alla clinica, Ospedale Sant’Anna, Ferrara, Italy

    Rocco Quatrale

  21. Clinica Neurologica, Azienda Ospedaliera Universitaria, Florence, Italy

    Silvia Ramat

  22. Neurologia, Ospedale S. Maria Loreto Nuovo, Naples, Italy

    Rossana Scala

  23. Neurofisiopatologia Dipartimento Neuro Orto Traumatologia, P.O. S. Luca, Vallo della Lucania, SA, Italy

    Giampiero Volpe

  24. Neurologia, Ospedale Umberto I, Enna, Italy

    Salvatore Zappulla

  25. Clinica Neurologica, Università Cattolica del Sacro Cuore, Rome, Italy

    Anna Rita Bentivoglio

  26. IRCCS San Raffaele, Rome, Italy

    Fabrizio Stocchi

  27. Neurologia, P.O.F. Ferrari, Casarano, Lecce, Italy

    Giorgio Trianni

  28. U.O. di Neurologia, Ospedale Versilia, Camaiore (PI), Italy

    Paolo Del Dotto

  29. Medidata srl, Modena, Italy

    Lucia Simoni

  30. Neurologia, Ospedale della Misericordia, Grosseto, Italy

    Roberto Marconi

Authors
  1. Carlo Colosimo
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  2. Letterio Morgante
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  3. Angelo Antonini
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  4. Paolo Barone
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  5. Tania P. Avarello
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  6. Edo Bottacchi
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  7. Antonino Cannas
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  8. Maria Gabriella Ceravolo
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  9. Roberto Ceravolo
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  10. Giulio Cicarelli
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  11. Rosa M. Gaglio
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  12. Luisa Giglia
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  13. Francesco Iemolo
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  14. Michela Manfredi
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  15. Giuseppe Meco
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  16. Alessandra Nicoletti
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  17. Massimo Pederzoli
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  18. Alfredo Petrone
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  19. Antonio Pisani
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  20. Francesco E. Pontieri
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  21. Rocco Quatrale
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  22. Silvia Ramat
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  23. Rossana Scala
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  24. Giampiero Volpe
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  25. Salvatore Zappulla
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  26. Anna Rita Bentivoglio
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  27. Fabrizio Stocchi
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  28. Giorgio Trianni
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  29. Paolo Del Dotto
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  30. Lucia Simoni
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  31. Roberto Marconi
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Consortia

and PRIAMO STUDY GROUP

Corresponding author

Correspondence to Carlo Colosimo.

Additional information

The members of the PRIAMO study group are listed in Appendix 1.

Appendix I: The PRIAMO study group

Appendix I: The PRIAMO study group

Steering Committee:

  • Angelo Antonini—Istituti Clinici di Perfezionamento, Milano,

  • Paolo Barone—Università Federico II, Napoli,

  • Carlo Colosimo—Sapienza Università di Roma,

  • Roberto Marconi—Ospedale della Misericordia, Grosseto,

  • Letterio Morgante—Università di Messina, Italy.

Participating centres:

  • Benincasa D—Ospedale Sant’Andrea, Sapienza Università di Roma

  • Biguzzi S—Ospedale Sant’Anna, Ferrara,

  • Braga M—Ospedale Civile, Vimercate,

  • Capecci M—Ospedale Umberto I, Ancona;

  • Caravona N—Sapienza Università di Roma,

  • D’Asta G—PO Guzzardi, Vittoria,

  • De Falco FA—Ospedale S Maria Loreto Nuovo, Napoli,

  • De Gaspari D, Pezzoli G—Parkinson Institute, Istituti Clinici di Perfezionamento, Milano,

  • Di Giovanni M, Ospedale Regionale, Aosta;

  • Floris G, Clinica Neurologica, Policlinico Universitario, Monserrato,Cagliari;

  • Gallerini S, Grasso L—Ospedale della Misericordia, Grosseto,

  • Gurgone G—Azienda Ospedaliera S. Giovanni di Dio, Agrigento,

  • Kiferle L, Ospedale Santa Chiara, Pisa;

  • Meoni S—Clinica Neurologica I, Azienda Ospedaliera Universitaria, Firenze

  • Morgante F, Savica R—Università di Messina,

  • Moschella V—Policlinico Tor Vergata, Roma,

  • Pepe F—Fondazione Poliambulanza, Brescia,

  • Petretta V—AORN San Giuseppe Moscati, Avellino,

  • Randisi MG—Azienda Ospedaliera S Elia, Caltanissetta,

  • Romeno M—Ospedale Villa Sofia CTO, Palermo,

  • Santangelo G, Ianniciello M—Università Federico II, Napoli,

  • Sorbello V—Policlinico Universitario, Catania,

  • Fabbrini G, Berardelli A—Sapienza Università di Roma

  • Guidubaldi A—Università Cattolica S Cuore, Roma,

  • Muoio R—IRCCS San Raffaele, Roma,

  • Toni V—PO F Ferrari, Casarano,

  • Logi C—Ospedale Versilia, Camaiore,

  • Ciacci G, Ulivelli M—Policlinico Le Scotte, Siena,

  • Perini M, Lanfranchi S—Ospedale S Antonio Abate, Gallarate,

  • Griffini S, Troianiello B—Istituto Clinico Città di Brescia,

  • Baratti M, Amidei S—Ospedale Ramazzini, Carpi,

  • Consoli D, Iellamo M—Ospedale G Iazzolino, Vibo Valentia,

  • Cuomo T—Ospedale Civile Umberto I, Nocera Inferiore,

  • Scaglioni A, Medici D—Ospedale di Vaio, Fidenza,

  • Abbruzzese G, Di Brigida G—Università degli Studi di Genova, Genova,

  • Cocco GA, Agnetti V—Università degli Studi di Sassari, Sassari,

  • Cossu G, Deriu M—Azienda Ospedaliera G Brotzu, Cagliari,

  • Abrignani M, Modica C—Ospedale San Biagio di Marsala, Marsala,

  • Albani G, Milan E—Istituto Scientifico San Giuseppe, Piancavallo,

  • Martinelli P, Scaglione C—Università di Bologna, Bologna,

  • Mucchiut M, Zanini S—Policlinico Universitario, Udine,

  • Pennisi F—Ospedale di Castelvetrano, Castelvetrano, Trapani,

  • Soliveri P, Albanese A—Istituto Nazionale Neurologico C Besta, Milano,

  • Bartolomei L, L’erario R—Ospedale Civile San Bortolo, Vicenza,

  • Capus L, Ferigo L—Ospedale di Gattinara, Trieste,

  • Marano R, Nastasi V—Azienda Ospedaliera Papardo, Messina,

  • Luciano R, Maiello L—Ospedale Monaldi, Napoli,

  • Simone P, Fogli D—Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo,

  • Lopiano L, Pesare M—ASO Molinette, Torino,

  • Nordera G, Pilleri E—Casa di Cura Villa Margherita, Arcugnano,

  • Scaravilli T—Azienda Ospedaliera Padova, Padova,

  • Giaccaglini E, Alesi C—Ospedale Civile, Jesi, Italy.

Sponsorship:

  • Tania Corbetta, Arina Dumitriu, Boehringer Ingelheim, Milano, Italy.

Project Management, Statistical Analyses and data management:

  • Simona Sgarbi, project leader MediData Studi e Ricerche, Modena

  • Andrea Rapisarda, clinical project manager MediData Studi e Ricerche, Modena

  • Sara Rizzoli, Lucia Simoni, statisticians MediData Studi e Ricerche, Modena

  • Luca Zanoli, clinical data manager MediData Studi e Ricerche, Modena

  • Alessandra Manfredi, clinical operation specialist MediData Studi e Ricerche, Modena, Italy.

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Colosimo, C., Morgante, L., Antonini, A. et al. Non-motor symptoms in atypical and secondary parkinsonism: the PRIAMO study. J Neurol 257, 5–14 (2010). https://doi.org/10.1007/s00415-009-5255-7

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  • DOI: https://doi.org/10.1007/s00415-009-5255-7

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