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MDR1 variants and risk of Parkinson disease

Association with pesticide exposure?

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Abstract

The multidrug resistance protein 1 (MDR1 or ABCB1) gene encodes a P-glycoprotein that protects the brain against neurotoxicants. Certain MDR1 genetic variants are known to compromise the function of this transporter and may thus be associated with Parkinson disease (PD). We therefore conducted a large case-control study investigating the potential relationship between MDR1 variants and PD. We determined the frequency of three MDR1 variants in 599 European PD patients and controls and further stratified the population by ethnicity, age at onset, and exposure to pesticides. We detected no relevant association in either the entire sample, or when separately investigating by ethnic origin or age at onset. However, the distribution of c.3435C/T differed significantly between PD patients exposed to pesticides compared to those non-exposed (odds ratio = 4.74; confidence interval = [1.009; 22.306]); p = 0.047), suggesting that common MDR1 variants might influence the risk to develop PD in conjunction with exposure to pesticides.

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Authors and Affiliations

  1. Dept. of Neurology and Schilling, Dept. for Clinical and Molecular Neurogenetics, University of Lübeck, Ratzeburger Allee 160, 23538, Lübeck, Germany

    Katja Zschiedrich BS, Norbert Brüggemann MD, Norman Kock MD, Meike Kasten MD, Christine Klein MD & Katja Lohmann PhD

  2. Institute of Medical Biometry and Statistics, University of Lübeck, Lübeck, Germany

    Inke R. König PhD & Andreas Ziegler PhD

  3. Dept. of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands

    Klaus L. Leenders MD

  4. Institute of Neurology CCS, School of Medicine, Belgrade, Serbia

    Vladimir Kostić MD

  5. Dept. of Neurology, Clinic of Lippe-Lemgo, Lemgo, Germany

    Peter Vieregge MD

Authors
  1. Katja Zschiedrich BS
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  2. Inke R. König PhD
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  3. Norbert Brüggemann MD
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  4. Norman Kock MD
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  5. Meike Kasten MD
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  6. Klaus L. Leenders MD
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  7. Vladimir Kostić MD
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  8. Peter Vieregge MD
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  9. Andreas Ziegler PhD
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  10. Christine Klein MD
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  11. Katja Lohmann PhD
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Correspondence to Christine Klein MD.

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Zschiedrich, K., König, I.R., Brüggemann, N. et al. MDR1 variants and risk of Parkinson disease. J Neurol 256, 115–120 (2009). https://doi.org/10.1007/s00415-009-0089-x

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  • DOI: https://doi.org/10.1007/s00415-009-0089-x

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