Abstract
We investigated the role of the CXCR3 chemokine CXCL11 (I–TAC) for leukocyte recruitment to the CSF in neuroborreliosis (NB). CXCL11 levels in the CSF of 17 patients with acute NB were elevated compared with 20 non–inflammatory controls (100.1 vs. 54.1pg/ml, p = 0.002). Using a modified Boyden chamber chemotaxis–assay, the CSF of patients with acute NB was more chemotactic than the control CSF–samples (p = 0.001). A strong correlation (p < 0.001) between CXCL11 levels, chemotactic activity and CSF–white cell count was detected. Though the chemotactic activity of CSF from NB patients was only partially reduced by a human recombinant CXCL11 antibody, these findings suggest that, among other chemotactic factors, CXCL11 may play a role in the chemotaxis of mononuclear cells in NB.
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Presented on the 14th Meeting of the European Neurological Society (Barcelona, Spain, 26–30 June, 2004). Informed consent for lumbar puncture was obtained from all patients. There was no special financial support. The authors have no conflict of interest
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Rupprecht, T.A., Koedel, ., Muhlberger, B. et al. CXCL11 is involved in leucocyte recruitment to the central nervous system in neuroborreliosis. J Neurol 252, 820–823 (2005). https://doi.org/10.1007/s00415-005-0752-9
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DOI: https://doi.org/10.1007/s00415-005-0752-9